Author: Nicholas Bruchovsky
Publisher: CRC Press
ISBN: 042955740X
Category : Medical
Languages : en
Pages : 256
Book Description
Published in 1983: In Volume 2 the clinical aspects of drug and hormone resistance are discussed. The Editors have concentrated on malignancies of the breast, endometrium, and prostate as relevant clinical examples.
Drug and Hormone Resistance in Neoplasia
Author: Nicholas Bruchovsky
Publisher: CRC Press
ISBN: 042955740X
Category : Medical
Languages : en
Pages : 256
Book Description
Published in 1983: In Volume 2 the clinical aspects of drug and hormone resistance are discussed. The Editors have concentrated on malignancies of the breast, endometrium, and prostate as relevant clinical examples.
Publisher: CRC Press
ISBN: 042955740X
Category : Medical
Languages : en
Pages : 256
Book Description
Published in 1983: In Volume 2 the clinical aspects of drug and hormone resistance are discussed. The Editors have concentrated on malignancies of the breast, endometrium, and prostate as relevant clinical examples.
Drug and Hormone Resistance in Neoplasia: Basic concepts
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Drug and Hormone Resistance in Neoplasia: Clinical concepts
Author: Nicholas Bruchovsky
Publisher: Boca Raton, Fla. : CRC Press, c1982-c1983.
ISBN: 9780849365171
Category : Medical
Languages : en
Pages : 167
Book Description
Publisher: Boca Raton, Fla. : CRC Press, c1982-c1983.
ISBN: 9780849365171
Category : Medical
Languages : en
Pages : 167
Book Description
Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer
Author: Stephen Hiscox
Publisher: Springer Science & Business Media
ISBN: 1402085265
Category : Medical
Languages : en
Pages : 202
Book Description
One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeutic constraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenues for future drug regimens. Written by experts in the subject area, this book covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book represents a timely publication in the field of breast cancer research, providing current knowledge in the area of drug resistance and will be important reading material for clinicians and researchers alike.
Publisher: Springer Science & Business Media
ISBN: 1402085265
Category : Medical
Languages : en
Pages : 202
Book Description
One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeutic constraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenues for future drug regimens. Written by experts in the subject area, this book covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book represents a timely publication in the field of breast cancer research, providing current knowledge in the area of drug resistance and will be important reading material for clinicians and researchers alike.
Drug and Hormone Resistance in Neoplasia
Author: Nicholas Bruchovsky
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 191
Book Description
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 191
Book Description
Drug and Hormone Resistance in Neoplasia: Basic concepts
Author: Nicholas Bruchovsky
Publisher: Boca Raton, Fla. : CRC Press, c1982-c1983.
ISBN: 9780849365164
Category : Cancer
Languages : en
Pages : 167
Book Description
Publisher: Boca Raton, Fla. : CRC Press, c1982-c1983.
ISBN: 9780849365164
Category : Cancer
Languages : en
Pages : 167
Book Description
Drug and Hormonal Resistance in Breast Cancer
Author: Robert Brent Dickson
Publisher: Prentice Hall PTR
ISBN:
Category : Medical
Languages : en
Pages : 474
Book Description
Featuring contributions from expert authors of international standing, this book explores emerging studies on the success and/or failure of chemotherapy in breast cancer. Covers the clinical resistance of breast cancer to treatment; chemo-hormonal reactions; anti-hormonal resistance; multidrug resistance; and fu/antimetabolites. For cancer and hormonal researchers and development scientists in pharmaceuticals and biomedicine. Previously announced in 7/93 PTR Catalog.
Publisher: Prentice Hall PTR
ISBN:
Category : Medical
Languages : en
Pages : 474
Book Description
Featuring contributions from expert authors of international standing, this book explores emerging studies on the success and/or failure of chemotherapy in breast cancer. Covers the clinical resistance of breast cancer to treatment; chemo-hormonal reactions; anti-hormonal resistance; multidrug resistance; and fu/antimetabolites. For cancer and hormonal researchers and development scientists in pharmaceuticals and biomedicine. Previously announced in 7/93 PTR Catalog.
Drug Resistance
Author: William N. Hait
Publisher: Springer Science & Business Media
ISBN: 1461312671
Category : Medical
Languages : en
Pages : 421
Book Description
Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.
Publisher: Springer Science & Business Media
ISBN: 1461312671
Category : Medical
Languages : en
Pages : 421
Book Description
Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.
Mechanisms of Drug Resistance in Neoplastic Cells
Author: Paul V. Woolley
Publisher: Elsevier
ISBN: 1483220753
Category : Medical
Languages : en
Pages : 417
Book Description
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Publisher: Elsevier
ISBN: 1483220753
Category : Medical
Languages : en
Pages : 417
Book Description
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Drug Resistance As a Biochemical Target in Cancer Chemotherapy
Author: Makoto Ogawa
Publisher: Academic Press
ISBN: 0323153887
Category : Medical
Languages : en
Pages : 371
Book Description
Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. Biomedical scientists and researchers and clinicians will find this book invaluable.
Publisher: Academic Press
ISBN: 0323153887
Category : Medical
Languages : en
Pages : 371
Book Description
Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. Biomedical scientists and researchers and clinicians will find this book invaluable.