Draft Toxicological Profile for Perchlorates PDF Download
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Author:
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 276
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Author:
Publisher:
ISBN:
Category : Health risk assessment
Languages : en
Pages : 276
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Author:
Publisher:
ISBN:
Category : Perchloric acid
Languages : en
Pages : 278
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Author:
Publisher:
ISBN:
Category : Perchlorates
Languages : en
Pages : 10
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Book Description
This Public Health Statement is the summary chapter from the Toxicological Profile for Perchlorates. It is one in a series of Public Health Statements about hazardous substances and their health effects. A shorter version, the ToxFAQ(tm), is also available. This information is important because these substances may harm you.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309181356
Category : Science
Languages : en
Pages : 276
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Perchlorateâ€"a powerful oxidant used in solid rocket fuels by the military and aerospace industryâ€"has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA's basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weightâ€"an amount more than 20 times the reference dose proposed by EPAâ€"should not threaten the health of even the most sensitive populations.
Author: Daland R. Juberg
Publisher: Am Cncl on Science, Health
ISBN:
Category : Drinking water
Languages : en
Pages : 40
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Author: DEPARTMENT OF HEALTH & HUMAN SERVICES
Publisher:
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Category :
Languages : en
Pages : 190
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Author:
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Category : Dichloroethylene
Languages : en
Pages : 190
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Author:
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ISBN:
Category : Dichloromethane
Languages : en
Pages : 244
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Author:
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Category : Environmental health
Languages : en
Pages : 388
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Author:
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ISBN:
Category : Dichloropropane
Languages : en
Pages : 0
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