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Author: Susumu Kusunoki
Publisher: Springer
ISBN: 4431555943
Category : Medical
Languages : en
Pages : 292
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Book Description
This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
Author: Susumu Kusunoki
Publisher: Springer
ISBN: 4431555943
Category : Medical
Languages : en
Pages : 292
Get Book Here
Book Description
This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.
Author: Robert J. Fox, MD
Publisher: Springer Publishing Company
ISBN: 0826125948
Category : Medical
Languages : en
Pages : 441
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Book Description
Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers. Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, diagnostic criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS. Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team. New to the Second Edition: Includes summary recommendations from new AAN practice guidelines for use of DMTs All chapters updated to reflect the latest literature and diagnostic criteria Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS Related autoimmune diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309072859
Category : Medical
Languages : en
Pages : 457
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Book Description
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Author: Amanda L. Piquet
Publisher: Springer Nature
ISBN: 3030618838
Category : Medical
Languages : en
Pages : 536
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Book Description
This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.
Author: Richard K. Burt
Publisher: CRC Press
ISBN: 1351364766
Category : Medical
Languages : en
Pages : 687
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Book Description
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
Author: Ian S. Zagon
Publisher:
ISBN: 9780994438133
Category :
Languages : en
Pages : 137
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Book Description
Author: T. Jock Murray, MD
Publisher: Demos Medical Publishing
ISBN: 193455927X
Category : Medical
Languages : en
Pages : 594
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Book Description
Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge.
Author: Frank A. Sloan
Publisher: Cambridge University Press
ISBN: 9780521576468
Category : Business & Economics
Languages : en
Pages : 292
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Book Description
As expenditure on health care has increasingly become an area of public debate and concern, public and private health care decision-makers have called for more rigorous use of cost-benefit and cost-effectiveness analysis to guide spending. Concerns have arisen, however, about the overall quality of such analyses. This book discusses and evaluates best-practice methods of conducting cost-benefit and cost-effectiveness studies of pharmaceuticals and other medical technologies. It encompasses a wide variety of topics, ranging from measuring cost and effectiveness to discounting to the use of dynamic modelling of cost-effectiveness. The book also includes conceptual and practical aspects of cost-effectiveness analysis by researchers who have conducted applied research in these areas. Rarely does the book provide a singular solution to a measurement problem; rather, the reader is directed to choices among alternative approaches and an analysis of the advantages and disadvantages of each.
Author: Judy Graham
Publisher: Simon and Schuster
ISBN: 1594779074
Category : Health & Fitness
Languages : en
Pages : 252
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Book Description
A totally revised and updated edition of the first book to offer a holistic approach to slowing the progression of MS • Provides guidance on special diets and nutritional supplements, exercise, alternative therapies, and the effects of negative and positive thoughts on MS • Explains how to reduce toxic overload from mercury and chemicals • Includes life wisdom and coping strategies from others who suffer with MS Judy Graham is an inspiration. Diagnosed with multiple sclerosis when she was just 26 years old, 35 years later Judy Graham is still walking, working, and has successfully birthed and raised a son who is now an adult. In this totally revised and updated edition of her groundbreaking Multiple Sclerosis, first published in 1984, she shares the natural treatments that have helped her and many others with MS stabilize or even reverse the condition. Beginning with the effects of diet, she explains that many people with MS have been eating the wrong foods and shows which foods are “good” and “bad,” how to recognize food sensitivities, and how to correct nutritional deficiencies using dietary supplements. She also looks at reducing the body’s toxic overload, whether from mercury amalgam fillings, chemicals, or medications. She presents the exercises with proven benefits for MS she has found most reliable and appropriate, such as yoga, pilates, and t’ai chi, and explores alternative therapies that provide relief and support to the body’s efforts to control MS, including acupuncture, reflexology, shiatsu, reiki, and ayurveda. Most important are the insights she provides on the effects of negative thoughts on MS. She demonstrates how a positive mental attitude can actually slow down or even reverse the progression of this disease. Judy Graham is living proof that, as devastating as a diagnosis of MS is, life can still be lived to its fullest.
Author: Mary Rensel
Publisher: Karger Medical and Scientific Publishers
ISBN: 1910797235
Category : Medical
Languages : en
Pages : 146
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Book Description
Since the last edition of this book, 'no evidence of disease activity' (NEDA) has been proposed as a new treatment target, early data on the first pharmacological treatments for progressive MS have emerged, and the first remyelination trial has shown positive effects on nerve repair. It is with this sense of optimism that the authors of 'Fast Facts: Multiple Sclerosis' have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team, including: • a concise overview of investigations and modern diagnostic criteria • a holistic approach to all signs and symptoms, and proactive relapse management • the latest disease-modifying drugs, including when to treat, choice of drug and risk versus benefit. With case histories that will help to guide treatment decisions, discussion of the special considerations for MS during pregnancy, and in children and the elderly, and a detailed outline of emerging therapies, this book will benefit all healthcare professionals involved in the care of patients with this complex disease.
