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Author: Leonor Leon
Publisher:
ISBN: 9781536108644
Category : Medical
Languages : en
Pages : 240
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Book Description
With the knowledge that there are several pieces of information concerning the chemotherapy of trypanosomatids, it is important to put together the different aspects of this subject. This book is an updated version of several areas such as molecular biology, biochemistry, immune response to the studied compounds, pharmacology, etc. The chapters were written by experts in those different specialties. It reinforces the necessity to look to those trypanosomatids associated with severe diseases, such as Chagas disease, leishmaniases and African trypanosomiasis, which constitute a public health problem in poor countries where basic sanitary conditions are non-existent. This book intends to show the importance of specific methodologies to save time and money during the drug development process. Each step should be carefully planned from the selection of test compounds, the choice of a molecular target within parasites, the definition of a lead compound and the adequacy of the animal models. It is also important to focus on the activity of compounds, synthetic or from natural sources, in different species and life stages of the parasites, besides the way these compounds are metabolized in these laboratory conditions. In conclusion, this book will bring you information that could stimulate the development of better treatments for these highly neglected diseases.
Author: Leonor Leon
Publisher:
ISBN: 9781536108644
Category : Medical
Languages : en
Pages : 240
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Book Description
With the knowledge that there are several pieces of information concerning the chemotherapy of trypanosomatids, it is important to put together the different aspects of this subject. This book is an updated version of several areas such as molecular biology, biochemistry, immune response to the studied compounds, pharmacology, etc. The chapters were written by experts in those different specialties. It reinforces the necessity to look to those trypanosomatids associated with severe diseases, such as Chagas disease, leishmaniases and African trypanosomiasis, which constitute a public health problem in poor countries where basic sanitary conditions are non-existent. This book intends to show the importance of specific methodologies to save time and money during the drug development process. Each step should be carefully planned from the selection of test compounds, the choice of a molecular target within parasites, the definition of a lead compound and the adequacy of the animal models. It is also important to focus on the activity of compounds, synthetic or from natural sources, in different species and life stages of the parasites, besides the way these compounds are metabolized in these laboratory conditions. In conclusion, this book will bring you information that could stimulate the development of better treatments for these highly neglected diseases.
Author: André L.S. Santos
Publisher: Springer Science & Business Media
ISBN: 9400773056
Category : Medical
Languages : en
Pages : 387
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Book Description
This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Author: Edgar Alfred Steck
Publisher:
ISBN:
Category : Protozoan diseases
Languages : en
Pages : 304
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Book Description
Author: Ian Maudlin
Publisher: CABI
ISBN: 9780851990347
Category : Medical
Languages : en
Pages : 644
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Book Description
This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.
Author: Edgar Alfred Steck
Publisher:
ISBN:
Category : Medical protozoology
Languages : en
Pages : 304
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Book Description
Author: Marcelo Santos da Silva
Publisher: Bentham Science Publishers
ISBN: 1681084058
Category : Medical
Languages : en
Pages : 612
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Book Description
Frontiers in Parasitology is an Ebook series devoted to publishing the latest and the most important advances in parasitology. Eminent scientists present reviews on the microbiology, cytology, epidemiology, genomics, and molecular biology of microbial parasites and their associated infections. Additionally, the series also gives information about new diagnostic and therapeutic protocols. The Ebook series is essential reading to all scientists involved in studying harmful microbes and their impact on human health.
Author: L. H. Chappell
Publisher: Cambridge University Press
ISBN: 9780521448352
Category : Medical
Languages : en
Pages : 116
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Book Description
This specially commissioned text covers a range of topics relating to chemotherapy and the immune system.
Author: Sajal Chakraborti
Publisher: Springer Nature
ISBN: 981138763X
Category : Science
Languages : en
Pages : 566
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Book Description
This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.
Author: Joseph Marr
Publisher: Elsevier
ISBN: 0080527884
Category : Science
Languages : en
Pages : 363
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Book Description
The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms. Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.
Author: Marek Skoneczny
Publisher: Frontiers Media SA
ISBN: 2832511775
Category : Science
Languages : en
Pages : 155
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Book Description
