Dictyostelium discoideum Protocols PDF Download
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Author: Ludwig Eichinger
Publisher: Springer Science & Business Media
ISBN: 1597451444
Category : Science
Languages : en
Pages : 556
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Book Description
Dictyostelium discoideum is a simple but fascinating eukaryotic microorg- ism, whose natural habitat is deciduous forest soil and decaying leaves, where the amoebae feed on bacteria and grow as independent single cells. Exhaustion of the bacterial food source triggers a developmental program, in which up to 100,000 cells aggregate by chemotaxis towards cAMP. Morphogenesis and cell different- tion then culminate in the production of spores enabling the organism to survive unfavorable conditions. Dictyostelium offers unique advantages for studying f- damental cellular processes with the aid of powerful molecular genetic, bioche- cal, and cell biological tools. These processes include signal transduction, chemotaxis, cell motility, cytokinesis, phagocytosis, and aspects of development such as cell sorting, pattern formation and cell type differentiation. Recently, D- tyostelium was also described as a suitable host for pathogenic bacteria in which one can conveniently study the process of infection. In addition, Dictyostelium has many of the experimental conveniences of Saccharomyces cerevisiae and is pr- ably the best experimentally manipulatable protozoan, providing insight into this diverse group of organisms, which includes some of the most dangerous human parasites. The recent completion of the Dictyostelium genome sequencing project strengthens the position of D. discoideum as a model organism. The completed genome sequence and other valuable community resources constitute the source for basic biological and biomedical research and for genome-wide analyses.
Author: Ludwig Eichinger
Publisher: Springer Science & Business Media
ISBN: 1597451444
Category : Science
Languages : en
Pages : 556
Get Book Here
Book Description
Dictyostelium discoideum is a simple but fascinating eukaryotic microorg- ism, whose natural habitat is deciduous forest soil and decaying leaves, where the amoebae feed on bacteria and grow as independent single cells. Exhaustion of the bacterial food source triggers a developmental program, in which up to 100,000 cells aggregate by chemotaxis towards cAMP. Morphogenesis and cell different- tion then culminate in the production of spores enabling the organism to survive unfavorable conditions. Dictyostelium offers unique advantages for studying f- damental cellular processes with the aid of powerful molecular genetic, bioche- cal, and cell biological tools. These processes include signal transduction, chemotaxis, cell motility, cytokinesis, phagocytosis, and aspects of development such as cell sorting, pattern formation and cell type differentiation. Recently, D- tyostelium was also described as a suitable host for pathogenic bacteria in which one can conveniently study the process of infection. In addition, Dictyostelium has many of the experimental conveniences of Saccharomyces cerevisiae and is pr- ably the best experimentally manipulatable protozoan, providing insight into this diverse group of organisms, which includes some of the most dangerous human parasites. The recent completion of the Dictyostelium genome sequencing project strengthens the position of D. discoideum as a model organism. The completed genome sequence and other valuable community resources constitute the source for basic biological and biomedical research and for genome-wide analyses.
Author: Richard H. Kessin
Publisher: Cambridge University Press
ISBN: 0521583640
Category : Science
Languages : en
Pages : 318
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Book Description
Dictyostelia are soil amoebae capable of extraordinary feats of survival, motility, chemotaxis, and development. Characterised by their ability to transform from a single-celled organism into an elaborate assemblage of thousands of synchronously-moving cells, Dictyostelids are often referred to as 'social amoebae', and have been the subjects of serious study since the 1930s. Research in this area has been instrumental in understanding many problems in cellular biology. Beginning with the history of Dictyostelids and discussing each stage of their development, this book considers the evolution of this unique organism, analyses the special properties of the Dictyostelid genome, and presents in detail the methods available, at the time of the book's original publication in 2001, to manipulate their genes. Representing the synthesis of such material and with an emphasis on combining classical experiments with modern molecular findings, this book will be essential for researchers and graduates in developmental and cellular biology.
Author: George M. Briggs
Publisher:
ISBN: 9781942341826
Category :
Languages : en
Pages :
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Book Description
Author: William Loomis
Publisher: Elsevier
ISBN: 032315980X
Category : Science
Languages : en
Pages : 225
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Book Description
Dictyostelium Discoideum: A Developmental System presents D. discoideum as a model eukaryotic system to study a variety of developmental problems. The book describes the life cycle of the organism D. discoideum which exists in nature as a soil amoeba in forest detritus. The nuclei of D. discoideum contain DNA, RNA, and proteins which have properties similar to those of histones present in calf thymus nuclei. The unique sequences of the genome of the organism code for the gene products synthesize during its growth and development. One approach in genetic analyses to understanding the developmental processes of the organism is to isolate a large number of morphological mutants. The isolation process will indicate the number of variations that are open to the developing system, and will point to causal connections between stages. The text also explains that the number of cells which differentiate into stalk cells is the result of timing and mechanics of the process of culmination. Ashworth (1971) suggests that cells in pseudoplasmodia of D. discoideum adjust their positions in relation to the chemical structure of the sheath itself. A model shows how cells communicate their response to the sheath in an axial fashion. The book can prove beneficial for biochemists, micro-biologists, cellular researchers, and investigators involved in the study of cellular biology.
Author: Maria Romeralo
Publisher: Springer Science & Business Media
ISBN: 3642384870
Category : Science
Languages : en
Pages : 259
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Book Description
Since their discovery in 1869, the dictyostelids have attracted the attention of scientists in a wide variety of fields. This interest has stemmed from their peculiar lifestyle and developmental properties, which were shaped by the evolutionary forces that generated multicellularity during eukaryotic evolution. More recently, the dictyostelids have gained attention due to the striking similarities found at the genomic, cellular and biochemical levels with human cells, which has propelled the species Dictyostelium discoideum to become a model system for biology and medicine in many laboratories. This book covers the latest advances in our knowledge of these extraordinary organisms with topics spanning from their evolutionary history, ecology and diversity to the recent discoveries regarding their cellular and molecular biology.
Author: Minoru Fukuda
Publisher: CRC Press
ISBN: 1040294871
Category : Science
Languages : en
Pages : 342
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Book Description
Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction. Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.
Author: Lindsay Olive
Publisher: Elsevier
ISBN: 0323156738
Category : Nature
Languages : en
Pages : 305
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Book Description
The Mycetozoans brings together, for the first time in a single volume, comprehensive information on the biology and classification of the mycetozoans and associated groups. The mycetozoans and their associates remain of prime interest to taxonomists and phylogenists because major new taxa continue to be discovered among them. This book informs the reader where to find mycetozoans, how to isolate and culture them, their life cycles and ultrastructure, and some of the experiments that may be performed with them. It presents studies on Protostelia (protostelids); Dictyostelia (dictyostelid cellular slime molds); Myxogastria (myxomycetes); Acrasea (acrasid cellular slime molds); Plasmodiophorina (plasmodiophorids); and Labyrinthulas (labyrinthulina and thraustochytrids). This text can serve as a reference tool in courses on mycetozoans, protozoology, mycology, and developmental biology of lower organisms, and as a concentrated source of information for research workers in all aspects of the biology and taxonomy of these organisms.
Author:
Publisher: Elsevier
ISBN: 0080463428
Category : Science
Languages : en
Pages : 297
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Book Description
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. - Includes 20 color figures - Latest volume in series, with eight reviews in more than 250 pages - Topics covered include bone remodeling, ex vivo adult stem cell expansion, calcium sensing receptors and more
Author: Marc H. Symons
Publisher: Springer Science & Business Media
ISBN: 9780306479922
Category : Science
Languages : en
Pages : 256
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Book Description
Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility. Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.
Author: D.-P. Häder
Publisher: Elsevier
ISBN: 008053886X
Category : Science
Languages : en
Pages : 959
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Book Description
This volume emphasizes the involvement of all facets of biology in the analysis of environmentally controlled movement responses. This includes biophysics, biochemistry, molecular biology and as an integral part of any approach to a closer understanding, physiology. The initial euphoria about molecular biology as the final solution for any problem has dwindled and the field agrees now that only the combined efforts of all facets of biology will at some day answer the question posed more than hundred years ago: "How can plants see?". One conclusion can be drawn from the current knowledge as summarized in this volume. The answer will most likely not be the same for all systems.
