Author: Khoa Dang Nguyen (Ph. D.)Publisher:
ISBN:
Category :
Languages : en
Pages : 1316
Book Description
Since C-C bonds form the backbone of every organic molecule and reside at the heart of chemical science, the development of new efficient methods for promoting C-C bond formation is of great significance. Inspired and expanded from traditional Grignard reactions, the work presented in this dissertation focuses on metal catalyzed neutral redox-triggered carbonyl addition via transfer hydrogenation. Advancing the native reducing capability of alcohols, employment of catalytic transition metals enables the formation of nucleophile-electrophile pairs in situ, en route to the products of formal alcohol C-H functionalization. These redox-triggered reactions circumvent the stoichiometric metallated byproduct waste and streamline the construction of complex molecules from simple and/or readily available feedstocks. The research reported herein discloses new developed methodologies of ruthenium and iridium catalyzed coupling reactions of primary and secondary alcohols with various pi-unsaturates. These studies contribute to the growing body of redox-triggered alcohol C-C couplings - new carbonyl addition chemistry that extends beyond the use of premetalated reagents.
