Development of an Orthogonal Acceleration Time-of-flight Mass Spectrometer PDF Download
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Author: Christopher Matthew Williams
Publisher:
ISBN:
Category : Atmospheric ionization
Languages : en
Pages :
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Book Description
Author: Christopher Matthew Williams
Publisher:
ISBN:
Category : Atmospheric ionization
Languages : en
Pages :
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Book Description
Author: Christopher Matthew Williams
Publisher:
ISBN:
Category : Atmospheric ionization
Languages : en
Pages : 0
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Book Description
Author: David Sean Selby
Publisher:
ISBN:
Category : Time-of-flight mass spectrometry
Languages : en
Pages : 364
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Book Description
Author: Hari Nair
Publisher: Academic Press
ISBN: 0128009926
Category : Science
Languages : en
Pages : 306
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Book Description
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
Author: David J. Rousell
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Nageeb Sousou
Publisher:
ISBN:
Category : Time-of-flight mass spectrometry
Languages : en
Pages : 476
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Book Description
Author: E.W. Schlag
Publisher: Newnes
ISBN: 0444596186
Category : Science
Languages : en
Pages : 424
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Book Description
The resurgence of time-of-flight mass spectrometry (TOF-MS) has had its origin in the simplicity of construction and application of such instruments together with the high transmission and the great increase in resolution that has been achieved. The instrument lends itself naturally to a coupling with pulsed laser sources, though this is not a prerequisite. It also affords a time resolution far beyond that traditionally achieved with mass spectrometric rapid scan techniques - a recent example being the real-time analysis of a multi-component mixture from an automobile exhaust. Furthermore, the mass range appears to be extremely large: mass up to 500 kDa and beyond what is being readily measured in the laboratory today. The present set of contributions attempts to give a survey of current applications from many of the active groups in the field. A variety of new applications are considered which are no doubt just the beginning of large new areas of application. By presenting this work in book form it is hoped that it will be of help to the many groups intending to initiate work in this rapidly expanding new area of mass spectrometry.
Author: Robert J. Cotter
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 360
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Book Description
This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.
Author: Wilfried M. A. Niessen
Publisher: John Wiley & Sons
ISBN: 1118500180
Category : Science
Languages : en
Pages : 421
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Book Description
Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Author: David. J. Rousell
Publisher:
ISBN:
Category : Accelerator mass spectrometry
Languages : en
Pages :
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Book Description
