Author: Hamad Musfer Alkhtani
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 470
Book Description
Design, Synthesis and Biological Evaluation of Novel Cyclin-dependent Kinase 9 Inhibitors as Anticancer Agents
Author: Hamad Musfer Alkhtani
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 470
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 470
Book Description
Anticancer Agents
Author: Qiao-Hong Chen
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems
Author: Xianrui Zhao
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents
Author: Jin Chen
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery
Author: Larisa Kuznetsova
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 584
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 584
Book Description
Design, Synthesis and Biological Evaluation of Highly Selective CDK9 Inhibitors for Cancer Treatment
Author: Hao Shao
Publisher:
ISBN:
Category : Cyclin-dependent kinases
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category : Cyclin-dependent kinases
Languages : en
Pages : 0
Book Description
The Design, Synthesis and Biological Evaluation of Novel Multiple Targeting Anti-cancer Agents
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
The Design, Synthesis, and Biological Evaluation of Novel Antitumor Agents
Author: Jude E. Mathews
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
Book Description
Synthesis and Biological Evaluation of Novel Anti-cancer Agents
Author: Nicola Dione Henderson
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 0
Book Description
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 0
Book Description
Anticancer Agents
Author: Qiao-Hong Chen
Publisher:
ISBN: 9783036501413
Category :
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Publisher:
ISBN: 9783036501413
Category :
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.