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Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 9780471498322
Category : Science
Languages : en
Pages : 266
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Book Description
Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems. Explores the structural and temporal complexity in biological signalling. Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks. Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations.
Author: Giovanna Di Marzo Serugendo
Publisher: Springer
ISBN: 3540247017
Category : Computers
Languages : en
Pages : 309
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Book Description
As information handling systems get more and more complex, it becomes increasingly difficult to manage them using traditional approaches based on centralized and pre-defined control mechanisms. Over recent years, there has been a significant increase in taking inspiration from biology, the physical world, chemistry, and social systems to more efficiently manage such systems - generally based on the concept of self-organisation; this gave rise to self-organising applications. This book constitutes a reference and starting point for establishing the field of engineering self-organising applications. It comprises revised and extended papers presented at the Engineering Self-Organising Applications Workshop, ESOA 2003, held at AAMAS 2003 in Melbourne, Australia, in July 2003 and selected invited papers from leading researchers in self-organisation. The book is organized in parts on applications, natural metaphors (multi-cells and genetic algorithms, stigmergy, and atoms and evolution), artificial interaction mechanisms, middleware, and methods and tools.
Author: Yoshiteru Ishida
Publisher: Springer Science & Business Media
ISBN: 3662078635
Category : Computers
Languages : en
Pages : 196
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Book Description
After I came to know Jerne's network theory on the immune system, I became fascinated with the immune system as an information system. The main pro totypes for biological information systems have been the neural systems and the brain. However, the immune system is not only an interesting informa tion system but it may provide a design paradigm for artificial information systems. With such a consideration, I initiated a project titled "autonomous decentralized recognition mechanism of the immune network and its applica tion to distributed information processing" in 1990 under a Grant-in-Aid for Scientific Research on a Priority Area ("Autonomous Distributed Systems") supported by the Ministry of Education, Science, and Culture. During the project, I promoted the idea that the immune system could be a prototype of autonomous distributed systems. After the project, we organized an international workshop on immunity based systems in 1996 in conjunction with the International Conference on Multi-Agent Systems held in Kyoto, Japan. Recently, there have been several international conferences related to topics inspired by the immune system and an increasing number of research papers related to the topic. In writing this book, a decade after the project, I still believe that the immune system can be a prototype, a compact but sophisticated system that nature has shown us for building artificial information systems in this network age of the twenty-first century.
Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 9780471498322
Category : Science
Languages : en
Pages : 266
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Book Description
Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems. Explores the structural and temporal complexity in biological signalling. Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks. Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations.
Author: Melanie Mitchell
Publisher: Oxford University Press
ISBN: 0199741026
Category : Science
Languages : en
Pages : 367
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Book Description
What enables individually simple insects like ants to act with such precision and purpose as a group? How do trillions of neurons produce something as extraordinarily complex as consciousness? In this remarkably clear and companionable book, leading complex systems scientist Melanie Mitchell provides an intimate tour of the sciences of complexity, a broad set of efforts that seek to explain how large-scale complex, organized, and adaptive behavior can emerge from simple interactions among myriad individuals. Based on her work at the Santa Fe Institute and drawing on its interdisciplinary strategies, Mitchell brings clarity to the workings of complexity across a broad range of biological, technological, and social phenomena, seeking out the general principles or laws that apply to all of them. Richly illustrated, Complexity: A Guided Tour--winner of the 2010 Phi Beta Kappa Book Award in Science--offers a wide-ranging overview of the ideas underlying complex systems science, the current research at the forefront of this field, and the prospects for its contribution to solving some of the most important scientific questions of our time.
Author: Alfred I. Tauber
Publisher: Oxford University Press
ISBN: 0190651253
Category : Science
Languages : en
Pages : 329
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Book Description
Modern immunology traditionally conceives of the immune system as providing defense against pathogens. Alfred I. Tauber criticizes this conception of immunity as too narrow, because it discounts much of the immune system's other normal functions. These include active tolerance of nutritional exchanges with the environment and the stabilization of cooperative relationships with resident micro-organisms. An expanded account extends immunity's functional role from singular 'defense' to broadened discernment of environmental 'exchange.' This ecological perspective has profound theoretical implications, for the basic notion of immune identity is reconfigured: highlighting the organism as a holobiont (a consortium of diverse organisms living in cooperative relationships) challenges prevailing concepts of individuality and the self/nonself dichotomy heretofore organizing immune theory. Indeed, if theoretical interest is focused on the challenges of maintaining immune balance in the full ecological context of the organism, then immune regulation assumes new complexity. Tauber maintains that the key to unravelling that puzzle requires a critical re-assessment of the cognitive processes that underlie immune effector functions. Accordingly, he provides the outline of a re-formulated 'cognitive paradigm' that dispenses with agent-based models and adopts an ecologically conceived understanding of perception and information processing. The implications of this revised configuration of immunity and its deconstructed notions of individuality and selfhood have wide significance for philosophers and life scientists working in immunology, ecology, and the cognitive sciences.
Author: Jason Brownlee
Publisher: Jason Brownlee
ISBN: 1446785068
Category : Computers
Languages : en
Pages : 437
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Book Description
This book provides a handbook of algorithmic recipes from the fields of Metaheuristics, Biologically Inspired Computation and Computational Intelligence that have been described in a complete, consistent, and centralized manner. These standardized descriptions were carefully designed to be accessible, usable, and understandable. Most of the algorithms described in this book were originally inspired by biological and natural systems, such as the adaptive capabilities of genetic evolution and the acquired immune system, and the foraging behaviors of birds, bees, ants and bacteria. An encyclopedic algorithm reference, this book is intended for research scientists, engineers, students, and interested amateurs. Each algorithm description provides a working code example in the Ruby Programming Language.
Author:
Publisher: Springer Science & Business Media
ISBN: 3540343830
Category : Computational complexity
Languages : en
Pages : 1169
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Book Description
Author: Bhattarai, Raj Kumar
Publisher: IGI Global
ISBN: 1522526285
Category : Business & Economics
Languages : en
Pages : 199
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Book Description
There can be no growth in a business without change. Learning how to cope with change and capitalize on new developments is pivotal to organizational growth. Enterprise Resiliency in the Continuum of Change: Emerging Research and Opportunities is a critical reference source that discusses the components of business-related change and how organizational leaders can progress their company through such alterations rather than fail during turbulent times. Highlighting important topics such as enterprise schemata, change triggers, company resiliency, and intervention theories, this scholarly publication is designed for business owners, enterprise leaders, professionals, and researchers interested in learning more about how to make an organization resilient during times of change.
Author: Thomas Deisboeck
Publisher: Springer Science & Business Media
ISBN: 0387335323
Category : Medical
Languages : en
Pages : 857
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Book Description
Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Author: Paul A. Fishwick
Publisher: CRC Press
ISBN: 1420010859
Category : Computers
Languages : en
Pages : 756
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Book Description
The topic of dynamic models tends to be splintered across various disciplines, making it difficult to uniformly study the subject. Moreover, the models have a variety of representations, from traditional mathematical notations to diagrammatic and immersive depictions. Collecting all of these expressions of dynamic models, the Handbook of Dynamic Sy
