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Author: World Health Organization
Publisher: Environmental Health Criteria
ISBN: 9789241572422
Category : Medical
Languages : en
Pages : 0
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Book Description
"IPCS, International Programme on Chemical Safety."
Author: World Health Organization
Publisher: Environmental Health Criteria
ISBN: 9789241572422
Category : Medical
Languages : en
Pages : 0
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Book Description
"IPCS, International Programme on Chemical Safety."
Author: Marc Williams
Publisher: Elsevier
ISBN: 0128004800
Category : Science
Languages : en
Pages : 725
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Book Description
Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species. - Provides detailed information on how Wildlife Toxicity Values (TRVs) for military chemicals of concern are derived and evaluated. - Covers wildlife toxicity assessments of explosives, metals and environmental chemicals. - Compiles relevant information on the environmental effects of chemicals on wildlife in relation to public and environmental health.
Author: Michael S. Roberts
Publisher: CRC Press
ISBN: 0849375924
Category : Medical
Languages : en
Pages : 706
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Book Description
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309310164
Category : Science
Languages : en
Pages : 475
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Book Description
Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.
Author: Acgih
Publisher: CRC Press
ISBN: 9780873711975
Category : Science
Languages : en
Pages : 344
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Book Description
What agents should be measured? How should measurement be performed and what averaging time should be used for the measurement? What sampling strategy should be employed to characterize exposures across individuals, locations, and time? What durations of exposure should be characterized? What statistical descriptors should be used to relate exposure to effect? Exposure Assessment for Epidemiology and Hazard Control examines various approaches to answering these and other important questions. Other topics discussed include the measurement of current exposures (e.g., vapors, gases, aerosols, and complex mixtures); the application of toxicological relationships, including biological markers and sample models; an epidemiological evaluation of exposure-effect relationships, including new methods for effect evaluation and models for population exposure estimates; and strategies for exposure assessment, such as biological sampling interpretation through toxicokinetic processes. This important new volume contains essential information for industrial hygienists, epidemiologists, occupational health physicians, toxicologists, and immunologists.
Author: Violaine Verougstraete
Publisher: Academic Press
ISBN: 0128110643
Category : Medical
Languages : en
Pages : 294
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Book Description
Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials. - Focuses on key information required to globally manage the risk of inorganic complex material - Includes user-friendly descriptions of methodologies and tools that facilitate chemicals management of such materials - Provides key messages to assist communication on risk assessment and risk management to audiences like regulators, workers and communities living around industrial sites
Author: Carey N. Pope
Publisher: Academic Press
ISBN: 0128136022
Category : Technology & Engineering
Languages : en
Pages : 644
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Book Description
An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.
Author: Wayne Ott
Publisher: CRC Press
ISBN: 9786610733576
Category : Biological monitoring
Languages : en
Pages : 0
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071067
Category :
Languages : en
Pages : 8
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Book Description
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author: Jeffrey W. Fisher
Publisher: Academic Press
ISBN: 0128196823
Category : Medical
Languages : en
Pages : 348
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Book Description
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. - Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology - Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research - Authored by expert editors and contributors who are among the best PBPK modelers in the world
