Cultivation of Bone Marrow Derived Progenitor Cells on Biomaterials PDF Download
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Author: Robert W. Carruth
Publisher:
ISBN:
Category : B cells
Languages : en
Pages : 138
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Book Description
Abstract: Progenitor cells have a considerable regenerative potential for damaged tissues. By utilizing these cells, vasculature or implant biocompatibility can be promoted. In this study we optimized the isolation protocol of bone marrow CD 117+ (ckit) progenitor cells. We differentiated CD1 17+ cells along an endothelial phenotype and tested their compatibility with various biomaterials. Biomaterials were compared for their proliferative properties using Laser Scanning Cytometry. We found the best endothelial progenitor cell growth on titanium and fibronectin coated porous aluminum oxide. These progenitor cell covered materials can be used to improve the function of future drug delivery systems or biosensors.
Author: Robert W. Carruth
Publisher:
ISBN:
Category : B cells
Languages : en
Pages : 138
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Book Description
Abstract: Progenitor cells have a considerable regenerative potential for damaged tissues. By utilizing these cells, vasculature or implant biocompatibility can be promoted. In this study we optimized the isolation protocol of bone marrow CD 117+ (ckit) progenitor cells. We differentiated CD1 17+ cells along an endothelial phenotype and tested their compatibility with various biomaterials. Biomaterials were compared for their proliferative properties using Laser Scanning Cytometry. We found the best endothelial progenitor cell growth on titanium and fibronectin coated porous aluminum oxide. These progenitor cell covered materials can be used to improve the function of future drug delivery systems or biosensors.
Author: Kee Woei Ng
Publisher: World Scientific Publishing Company
ISBN: 9814578258
Category : Technology & Engineering
Languages : en
Pages : 213
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Book Description
This is the first experimental protocol book that covers the differentiation of bone marrow-derived stem cells (BMSCs) into specific cell types, targeted at the undergraduate and graduate student level. The 19 chapters deal with the differentiation methods using small molecules, cytokines and polymeric scaffolds.BMSCs are pluripotential in that they not only act as myelo-regenerative and supportive cells, but can also differentiate into almost any kind of cells in our body. In addition, when implanted in vivo, they could help repair multiple tissues such as blood vessels, heart, liver and so on.For the differentiation of BMSCs, many methods have been introduced to adjust their microenvironment (chemical and physical cues), including chemical induction methods using large or small molecules and pellet culture; mechanical stimulation induction methods using cyclic mechano-transduction or ultrasonication; cytokine-released method using scaffolds; and so on.
Author: Julia M. Polak
Publisher: World Scientific
ISBN: 1848161824
Category : Medical
Languages : en
Pages : 947
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Book Description
Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field.
Author: Ngan Huang
Publisher: World Scientific
ISBN: 9813147768
Category : Science
Languages : en
Pages : 567
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Book Description
Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary.This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs, including cardiovascular, musculoskeletal, neurological and skin tissues. The technology platforms for studying and engineering stem cells, such as hydrogel and biomaterials development, microfluidics system and microscale patterning, are also illustrated. Regulatory challenges and quality control for clinical translation are also detailed. This book provides an comprehensive update on the advancement in the field of stem cells and regenerative medicine, and serves as a valuable resource for both researchers and students.
Author: Murugan Ramalingam
Publisher: CRC Press
ISBN: 1439879265
Category : Medical
Languages : en
Pages : 554
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Book Description
Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Bi
Author: Jan A. Nolta
Publisher: Springer Science & Business Media
ISBN: 140203959X
Category : Science
Languages : en
Pages : 173
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Book Description
MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
Author: Song Li
Publisher: World Scientific
ISBN: 9814464473
Category : Science
Languages : en
Pages : 473
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Book Description
Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.
Author: David Schaffer
Publisher: CRC Press
ISBN: 143987204X
Category : Medical
Languages : en
Pages : 233
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Book Description
While the potential of stem cells is recognized, their proliferation and differentiation must be more precisely controlled to maximize the production of therapeutically relevant cells and for cell replacement therapies to minimize contamination with residual cells that can give rise to side effects. How can engineers make contributions to address these challenges? With contributions from pioneers and experts, Stem Cell Engineering: Principles and Practices highlights recent advances in the understanding of the cellular and molecular composition of the stem cell niche, as well as approaches to build upon this basic information to direct stem cell differentiation into therapeutically valuable lineages. The growing recognition of stem cells as an important and exciting field will continue to draw investigators with diverse backgrounds—from biology, engineering, and the physical sciences—and thereby enable further progress in these and other new directions. This book discusses advances made during the last decade that have led to increasingly defined culture systems for growing stem cells, starting from co-culture with feeder cells in the presence of serum to growth on synthetic substrates in defined medium. In addition to highlighting many recent advances, it underscores the need for future work.
Author: Akon Higuchi
Publisher: Royal Society of Chemistry
ISBN: 1788012070
Category : Science
Languages : en
Pages : 408
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Book Description
Human pluripotent stem cells (hPSCs), which cover both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), show promise for drug discovery and regenerative medicine applications. These stem cells cannot be cultured on conventional tissue culture dishes but on biomaterials that have specific interactions with the hPSCs. Differentiation is regulated by the biological and physical cues conferred by the biomaterial. This book provides a systematic treatment of these topics bridging the gap between fundamental biomaterials research of stem cells and their use in clinical trials. The author looks at hPSC culture on a range of biomaterial substrates. Differentiation and control of hESCs and iPSCs into cardiomyocytes, osteoblasts, neural lineages and hepatocytes are covered. The author then considers their translation into stem cell therapies and looks at clinical trials across spinal cord injury, macular degeneration, bone disease and myocardial infarction. Finally, a chapter on future directions closes the book. By using this book, the reader will gain a robust overview of current research and a clearer understanding of the status of clinical trials for stem cell therapies.
Author: Loredana De Bartolo
Publisher: CRC Press
ISBN: 1466576405
Category : Medical
Languages : en
Pages : 658
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Book Description
Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on bioma
