Cross-over Trials in Clinical Research PDF Download
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Author: Stephen S. Senn
Publisher: John Wiley & Sons
ISBN: 0470854588
Category : Mathematics
Languages : en
Pages : 364
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Book Description
Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.
Author: Stephen S. Senn
Publisher: John Wiley & Sons
ISBN: 0470854588
Category : Mathematics
Languages : en
Pages : 364
Get Book Here
Book Description
Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.
Author: Stephen Jay Gould
Publisher: Three Rivers Press (CA)
ISBN:
Category : Science
Languages : en
Pages : 174
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Book Description
Crossing Over, the latest of three collaborations between scholar Stephen Jay Gould and artist Rosamond Wolff Purcell, brings together thought-provoking essays and uncannily beautiful photographs to disprove the popular notion that art and science exist in an antagonistic relationship. The essays and photographs collected here present art and science in conversation, rather than in opposition. As Gould writes in his preface, although the two disciplines may usually communicate in different dialects, when juxtaposed they strikingly reflect upon and enhance one another. Working together, Purcell's photographs and Gould's scientific musings speak to us about ourselves and our world in a hybrid language richer than either could command on its own. In an essay on individuality, for instance, Gould looks through the lens of evolutionary theory to address the controversial issue of cloning and the often misguided fears it evokes. As a society that exalts the concept of the individual, Gould argues, we sometimes fail to recognize that clones walk among us. Identical twins represent "the greatest of all challenges to our concept of individuality." Rosamond Purcell's photograph depicting the famous Siamese conjoined twins Eng and Chang conveys an eerie feeling that cannot be captured in words. Through its unique combination of words and photographs, Crossing Over prompts us to ponder not only the basis of the false dichotomy between art and science, but also the distinction of mind and nature, and of all humanly imposed categories of order. Gould and Purcell's work convinces the reader that a provocative interplay between art and science is not only possible, but inevitable and necessaryas well.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: American Bar Association. House of Delegates
Publisher: American Bar Association
ISBN: 9781590318737
Category : Law
Languages : en
Pages : 216
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Book Description
The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
Author: Byron Jones
Publisher: CRC Press
ISBN: 9780412606403
Category : Mathematics
Languages : en
Pages : 412
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Book Description
The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.
Author: B. Trezise
Publisher: Springer
ISBN: 1137336226
Category : History
Languages : en
Pages : 257
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Book Description
Performing Feeling in Cultures of Memory brings memory studies into conversation with a focus on feelings as cultural actors. It charts a series of memory sites that range from canonical museums and memorials, to practices enabled by the virtual terrain of Second Life, popular 'trauma TV' programs and radical theatre practice.
Author: Ruth Irene Garrett
Publisher: Harper Collins
ISBN: 0062277103
Category : Biography & Autobiography
Languages : en
Pages : 212
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Book Description
A work Booklist called ଯving and life–affirming, Crossing Over is the true story of one woman's extraordinary flight from the protected world of the Amish people to the chaos of contemporary life. Ruth Irene Garrett was the fifth of seven children raised in Kalona, Iowa, as a member of a strict Old Order Amish community. She was brought up in a world filled with rigid rules and intense secrecy, in an environment where the dress, buggies, codes of conduct, and way of life differed even from other Amish societies only 100 miles away. This Old Order community actively avoided all interaction with ೨e Englishߜ'96 everyone who lived on the outside. As a result, Ruth knew only one way of life, and one way of doing things. This compelling narrative takes us inside a hidden community, offering a striking look as one woman comes to terms with her discontent and ultimately leaves her family, faith and the sheltered world of her childhood. Unsatisfied, she bravely crosses over to contemporary life to fully explore the foreign and frightening reality in hope of better understanding her emotional and spiritual desires. What emerges is a powerful tale of one woman's search for meaning and the extraordinary lessons she learns along the way.
Author: Jeffrey M. Wooldridge
Publisher: MIT Press
ISBN: 0262232588
Category : Business & Economics
Languages : en
Pages : 1095
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Book Description
The second edition of a comprehensive state-of-the-art graduate level text on microeconometric methods, substantially revised and updated. The second edition of this acclaimed graduate text provides a unified treatment of two methods used in contemporary econometric research, cross section and data panel methods. By focusing on assumptions that can be given behavioral content, the book maintains an appropriate level of rigor while emphasizing intuitive thinking. The analysis covers both linear and nonlinear models, including models with dynamics and/or individual heterogeneity. In addition to general estimation frameworks (particular methods of moments and maximum likelihood), specific linear and nonlinear methods are covered in detail, including probit and logit models and their multivariate, Tobit models, models for count data, censored and missing data schemes, causal (or treatment) effects, and duration analysis. Econometric Analysis of Cross Section and Panel Data was the first graduate econometrics text to focus on microeconomic data structures, allowing assumptions to be separated into population and sampling assumptions. This second edition has been substantially updated and revised. Improvements include a broader class of models for missing data problems; more detailed treatment of cluster problems, an important topic for empirical researchers; expanded discussion of "generalized instrumental variables" (GIV) estimation; new coverage (based on the author's own recent research) of inverse probability weighting; a more complete framework for estimating treatment effects with panel data, and a firmly established link between econometric approaches to nonlinear panel data and the "generalized estimating equation" literature popular in statistics and other fields. New attention is given to explaining when particular econometric methods can be applied; the goal is not only to tell readers what does work, but why certain "obvious" procedures do not. The numerous included exercises, both theoretical and computer-based, allow the reader to extend methods covered in the text and discover new insights.
Author: Hartmut Porst
Publisher: John Wiley & Sons
ISBN: 1405178728
Category : Medical
Languages : en
Pages : 416
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Book Description
The new international standard reference work for sexual medicine Written under the auspices of the International Society for Sexual Medicine, (www.issm.info), the leading professional society in sexual medicine and founder of the most influential journal in the field, The Journal of Sexual Medicine, published by Blackwell Publishing Comprehensive coverage of the full range of diagnostic and treatment options in all aspects of male and female sexual dysfunctions Provides information on recent progress in pharmacologic approaches, including the highly successful drug treatments for ED Useful for any part of the patient-clinician consultation, from gathering symptoms to diagnosis to treatment to reports on potential and developing treatments
Author: Joyce L. Epstein
Publisher: Corwin Press
ISBN: 1483320014
Category : Education
Languages : en
Pages : 508
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Book Description
Strengthen programs of family and community engagement to promote equity and increase student success! When schools, families, and communities collaborate and share responsibility for students′ education, more students succeed in school. Based on 30 years of research and fieldwork, the fourth edition of the bestseller School, Family, and Community Partnerships: Your Handbook for Action, presents tools and guidelines to help develop more effective and more equitable programs of family and community engagement. Written by a team of well-known experts, it provides a theory and framework of six types of involvement for action; up-to-date research on school, family, and community collaboration; and new materials for professional development and on-going technical assistance. Readers also will find: Examples of best practices on the six types of involvement from preschools, and elementary, middle, and high schools Checklists, templates, and evaluations to plan goal-linked partnership programs and assess progress CD-ROM with slides and notes for two presentations: A new awareness session to orient colleagues on the major components of a research-based partnership program, and a full One-Day Team Training Workshop to prepare school teams to develop their partnership programs. As a foundational text, this handbook demonstrates a proven approach to implement and sustain inclusive, goal-linked programs of partnership. It shows how a good partnership program is an essential component of good school organization and school improvement for student success. This book will help every district and all schools strengthen and continually improve their programs of family and community engagement.
