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Author: Byron Jones
Publisher: CRC Press
ISBN: 1439861420
Category : Mathematics
Languages : en
Pages : 440
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Book Description
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.
Author: Byron Jones
Publisher: CRC Press
ISBN: 1439861420
Category : Mathematics
Languages : en
Pages : 440
Get Book Here
Book Description
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.
Author: Byron Jones
Publisher: CRC Press
ISBN: 9780412606403
Category : Mathematics
Languages : en
Pages : 412
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Book Description
The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.
Author: Stephen S. Senn
Publisher: John Wiley & Sons
ISBN: 0470854588
Category : Mathematics
Languages : en
Pages : 364
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Book Description
Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.
Author: Hartmut Porst
Publisher: John Wiley & Sons
ISBN: 1405178728
Category : Medical
Languages : en
Pages : 416
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Book Description
The new international standard reference work for sexual medicine Written under the auspices of the International Society for Sexual Medicine, (www.issm.info), the leading professional society in sexual medicine and founder of the most influential journal in the field, The Journal of Sexual Medicine, published by Blackwell Publishing Comprehensive coverage of the full range of diagnostic and treatment options in all aspects of male and female sexual dysfunctions Provides information on recent progress in pharmacologic approaches, including the highly successful drug treatments for ED Useful for any part of the patient-clinician consultation, from gathering symptoms to diagnosis to treatment to reports on potential and developing treatments
Author: Patricia A. Alexander
Publisher: Psychology Press
ISBN: 0805849378
Category : Education
Languages : en
Pages : 1048
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Book Description
Provides coverage of the field of educational psychology. This book includes topics, such as, adult development, self-regulation, changes in knowledge and beliefs, and writing. It is useful to scholars, teacher educators, practitioners, policy makers, and academic libraries. It is also suitable for graduate level courses in educational psychology.
Author: Somak Biswas
Publisher: Cambridge University Press
ISBN: 100933798X
Category : History
Languages : en
Pages : 311
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Book Description
Analyses the phenomenon of western Indophilia, its ideological and affective composition, and its political implications in late-colonial British India. Argues that Indophile deployments around transnational projects like abolishing indentured labour and global Hinduism, while anti-colonial, were not necessarily emancipatory.
Author: Kenneth M. Hargreaves
Publisher: Elsevier Health Sciences
ISBN: 8131258092
Category : Medical
Languages : en
Pages : 994
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Book Description
Stay up on the latest research and techniques in endodontics with Cohen's Pathways of the Pulp, 12th Edition, SAE. Written by a team of internationally renowned experts and trusted for more than 40 years, this definitive guide covers the science, theory, and practice of endodontics. Full color illustrations and detailed radiographs guide readers through each step of endodontic care †from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. This new twelfth edition also boasts the very latest evidence-based research and techniques, reorganized and condensed chapters, plus other features designed to help you locate important information quickly and easily. Extensive illustration collection includes over 2,000 full-color photos, line art, and radiographs to clearly demonstrate core concepts and reinforce the essential principles and techniques of endodontics. Diverse and respected contributor pool includes experts from many national- and international-based dental education programs. NEW! Updated content and new images incorporate the most recent developments in research and clinical endodontic techniques. NEW! Additional topics cover pulp biology, pathobiology, diagnosis, treatment planning, pain control, isolation, access, cleaning and shaping, obturation, restoration, assessment of outcomes, emergencies and surgery. NEW! Compliance with the Commission on Dental Accreditation Curriculum ensures that the needs of all dental programs are met. NEW! Reorganized sections now divide chapters by those covering clinical endodontics, those covering the biological basis of endodontics, and chapters which detail endodontics in private practice to make content easier for both clinicians and students to navigate. NEW! Condensed chapters remove unnecessary duplication of content across the text and make the physical text lighter and easier to use.
Author: B. Trezise
Publisher: Springer
ISBN: 1137336226
Category : History
Languages : en
Pages : 257
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Book Description
Performing Feeling in Cultures of Memory brings memory studies into conversation with a focus on feelings as cultural actors. It charts a series of memory sites that range from canonical museums and memorials, to practices enabled by the virtual terrain of Second Life, popular 'trauma TV' programs and radical theatre practice.
Author: Sandra L. Beckett
Publisher: Routledge
ISBN: 1135861307
Category : Literary Collections
Languages : en
Pages : 360
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Book Description
In Crossover Fiction, Sandra L. Beckett explores the global trend of crossover literature and explains how it is transforming literary canons, concepts of readership, the status of authors, the publishing industry, and bookselling practices. This study will have significant relevance across disciplines, as scholars in literary studies, media and cultural studies, visual arts, education, psychology, and sociology examine the increasingly blurred borderlines between adults and young people in contemporary society, notably with regard to their consumption of popular culture.
Author: Branislav Jeremić
Publisher: Springer Science & Business Media
ISBN: 9783540005223
Category : Medical
Languages : en
Pages : 564
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Book Description
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
