Control of Regulatory T cell Stability, Plasticity and Function in Health and Disease PDF Download
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Author: Margarita Dominguez-Villar
Publisher: Frontiers Media SA
ISBN: 2889665704
Category : Medical
Languages : en
Pages : 269
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Book Description
Author: Margarita Dominguez-Villar
Publisher: Frontiers Media SA
ISBN: 2889665704
Category : Medical
Languages : en
Pages : 269
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Book Description
Author: Jonathan Soboloff
Publisher: CRC Press
ISBN: 149870509X
Category : Medical
Languages : en
Pages : 258
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Book Description
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author: B. Kyewski
Publisher: Springer Science & Business Media
ISBN: 9783540244448
Category : Medical
Languages : en
Pages : 352
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Book Description
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival.
Author: Dipayan Rudra
Publisher: Frontiers Media SA
ISBN: 2832515843
Category : Medical
Languages : en
Pages : 246
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Book Description
Author: Song-Guo Zheng
Publisher:
ISBN: 9789811564086
Category :
Languages : en
Pages : 0
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Book Description
This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters. The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.
Author: Graeme Milligan
Publisher: Springer
ISBN: 3319506935
Category : Medical
Languages : en
Pages : 258
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Book Description
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
Author: Rémy Bosselut
Publisher: Humana
ISBN: 9781493928088
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Hubert Schrezenmeier
Publisher: Cambridge University Press
ISBN: 9780521641012
Category : Medical
Languages : en
Pages : 410
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Book Description
Comprehensive and up-to-date clinical reference, with an emphasis on treatment.
Author: Shailza Singh
Publisher: Springer
ISBN: 9789811533525
Category : Medical
Languages : en
Pages : 0
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Book Description
Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.
Author: Ganji Purnachandra Nagaraju
Publisher: Elsevier
ISBN: 0443247439
Category : Science
Languages : en
Pages : 943
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Book Description
Immune Therapy for Pancreatic and Colon Cancer expands the knowledge on pathways, immune modulators, immune check points, and monoclonal antibodies that can lead to appropriate cancer treatment. With a strong focus on the development of immune therapies to improve the survival rates of pancreatic and colon cancer, this book also shows the latest trends in immune targeted approaches for cancer treatment. Sections describe the role of and the immune response to pancreatic and colon cancer, gives insights to past and current immunotherapies, including metabolic reprogramming, immune blockade therapy and immune modulation.This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic and colon cancer, inspire them and guide their design of novel experimental projects and translational studies. - Aims to incorporate diverse and novel immunotherapeutic strategies, targeting a wide array of tumor-induced immune escape mechanisms - Elucidates both past and current differences in immunotherapies, while also including strategies based on monoclonal antibodies' vaccine, and oncolytic virus-related immunotherapies - Provides an updated understanding of the how resistance breaks with immunotherapy in both pancreatic and colon cancer
