Context-Dependency of Renin-Angiotensin-Aldosterone System Genes in Relation to Left Ventricular Structure PDF Download
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Author: Tatiana Kuznetsova
Publisher: Leuven University Press
ISBN: 9789058673923
Category : Medical
Languages : en
Pages : 196
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Author: Tatiana Kuznetsova
Publisher: Leuven University Press
ISBN: 9789058673923
Category : Medical
Languages : en
Pages : 196
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Author: Jiguang Wang
Publisher: Leuven University Press
ISBN: 9789058673992
Category :
Languages : en
Pages : 206
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Author: Jennifer S. Yarden
Publisher: Leuven University Press
ISBN: 9789058674807
Category : Medical
Languages : en
Pages : 192
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Author: Zsolt Szelid
Publisher: Leuven University Press
ISBN: 9789058674548
Category : Medical
Languages : en
Pages : 116
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This is a Ph.D. dissertation. Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.
Author: Tim Nawrot
Publisher: Leuven University Press
ISBN: 9789058674609
Category : Medical
Languages : en
Pages : 168
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Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.
Author: Frank Struyf
Publisher: Leuven University Press
ISBN: 9789058674012
Category : Medical
Languages : en
Pages : 142
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Author: Omar Nyabi
Publisher: Leuven University Press
ISBN: 9789058674593
Category : Science
Languages : en
Pages : 122
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Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
Author: Jessa Yperman
Publisher: Leuven University Press
ISBN: 9789058675477
Category :
Languages : en
Pages : 156
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Author: Tom Vandebroek
Publisher: Leuven University Press
ISBN: 9789058675439
Category : Science
Languages : en
Pages : 160
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Author: Nico Hendrickx
Publisher: Leuven University Press
ISBN: 9789058675286
Category : Medical
Languages : en
Pages : 154
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