Author: Dr. K. Ravishankar
Publisher: ThinkPlus Pharma Publications
ISBN: 8197973121
Category : Medical
Languages : en
Pages : 296
Book Description
"Computational Advancements in Research and Education for Pharmaceutical Excellence: CARE 2024" is a comprehensive compilation of research papers and expert presentations from the two-day national conference held at Aditya Group of Pharmacy Colleges, Surampalem. This collection captures the latest developments in computational technologies transforming pharmaceutical research, development, and education. The proceedings begin with inspiring insights from Padma Bhushan Dr. K.I. Varaprasad Reddy, whose journey from electronics to biotechnology exemplifies the interdisciplinary nature of modern pharmaceutical innovation. Through plenary lectures from leading experts, the book explores critical areas including AI-driven drug discovery, quantum computing applications in drug metabolism studies, machine learning in analytical excellence, digital transformation in pharmacy education, and regulatory perspectives on computational pharmaceutical sciences. This publication serves as an invaluable resource for researchers, educators, industry professionals, and policymakers interested in the integration of computational tools in pharmaceutical sciences.
Conference Proceedings of National Conference on Computational Advancements in Research and Education for Pharmaceutical Excellence (CARE 2024)
Author: Dr. K. Ravishankar
Publisher: ThinkPlus Pharma Publications
ISBN: 8197973121
Category : Medical
Languages : en
Pages : 296
Book Description
"Computational Advancements in Research and Education for Pharmaceutical Excellence: CARE 2024" is a comprehensive compilation of research papers and expert presentations from the two-day national conference held at Aditya Group of Pharmacy Colleges, Surampalem. This collection captures the latest developments in computational technologies transforming pharmaceutical research, development, and education. The proceedings begin with inspiring insights from Padma Bhushan Dr. K.I. Varaprasad Reddy, whose journey from electronics to biotechnology exemplifies the interdisciplinary nature of modern pharmaceutical innovation. Through plenary lectures from leading experts, the book explores critical areas including AI-driven drug discovery, quantum computing applications in drug metabolism studies, machine learning in analytical excellence, digital transformation in pharmacy education, and regulatory perspectives on computational pharmaceutical sciences. This publication serves as an invaluable resource for researchers, educators, industry professionals, and policymakers interested in the integration of computational tools in pharmaceutical sciences.
Publisher: ThinkPlus Pharma Publications
ISBN: 8197973121
Category : Medical
Languages : en
Pages : 296
Book Description
"Computational Advancements in Research and Education for Pharmaceutical Excellence: CARE 2024" is a comprehensive compilation of research papers and expert presentations from the two-day national conference held at Aditya Group of Pharmacy Colleges, Surampalem. This collection captures the latest developments in computational technologies transforming pharmaceutical research, development, and education. The proceedings begin with inspiring insights from Padma Bhushan Dr. K.I. Varaprasad Reddy, whose journey from electronics to biotechnology exemplifies the interdisciplinary nature of modern pharmaceutical innovation. Through plenary lectures from leading experts, the book explores critical areas including AI-driven drug discovery, quantum computing applications in drug metabolism studies, machine learning in analytical excellence, digital transformation in pharmacy education, and regulatory perspectives on computational pharmaceutical sciences. This publication serves as an invaluable resource for researchers, educators, industry professionals, and policymakers interested in the integration of computational tools in pharmaceutical sciences.
Artificial Intelligence in Drug Discovery
Author: Nathan Brown
Publisher: Royal Society of Chemistry
ISBN: 1839160543
Category : Computers
Languages : en
Pages : 425
Book Description
Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
Publisher: Royal Society of Chemistry
ISBN: 1839160543
Category : Computers
Languages : en
Pages : 425
Book Description
Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
Guide for the Care and Use of Laboratory Animals
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309154006
Category : Science
Languages : en
Pages : 246
Book Description
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Publisher: National Academies Press
ISBN: 0309154006
Category : Science
Languages : en
Pages : 246
Book Description
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Science, the Endless Frontier
Author: Vannevar Bush
Publisher: Princeton University Press
ISBN: 069120165X
Category : Science
Languages : en
Pages : 186
Book Description
The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science.
Publisher: Princeton University Press
ISBN: 069120165X
Category : Science
Languages : en
Pages : 186
Book Description
The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science.
Social Science Research
Author: Anol Bhattacherjee
Publisher: CreateSpace
ISBN: 9781475146127
Category : Science
Languages : en
Pages : 156
Book Description
This book is designed to introduce doctoral and graduate students to the process of conducting scientific research in the social sciences, business, education, public health, and related disciplines. It is a one-stop, comprehensive, and compact source for foundational concepts in behavioral research, and can serve as a stand-alone text or as a supplement to research readings in any doctoral seminar or research methods class. This book is currently used as a research text at universities on six continents and will shortly be available in nine different languages.
Publisher: CreateSpace
ISBN: 9781475146127
Category : Science
Languages : en
Pages : 156
Book Description
This book is designed to introduce doctoral and graduate students to the process of conducting scientific research in the social sciences, business, education, public health, and related disciplines. It is a one-stop, comprehensive, and compact source for foundational concepts in behavioral research, and can serve as a stand-alone text or as a supplement to research readings in any doctoral seminar or research methods class. This book is currently used as a research text at universities on six continents and will shortly be available in nine different languages.
Digital Pathology
Author: Liron Pantanowitz
Publisher:
ISBN: 9780891896104
Category : Medical informatics
Languages : en
Pages : 304
Book Description
The definitive, complete reference of digital pathology! An extraordinarily comprehensive and complete book for individuals with anything from minimal knowledge to deep, accomplished experience in digital pathology. Easy to read and plainly written, Digital Pathology examines the history and technological evolution of digital pathology, from the birth of scanning technology and telepathology to three-dimensional imaging on large multi-touch displays and computer aided diagnosis. A must-have book for anyone wishing to learn more about and work in this exciting and critical information environment including pathologists, laboratory professionals, students and any other medical practitioners with a particular interest in the history and future of digital pathology. It can also be a useful reference for anyone, medical or non-medical, who have an interest in learning more about the field. Digital pathology is truly a game changer, and this book is a crucial tool for anyone wishing to know more. Subjects discussed in depth include: Static digital imaging; basics and clinical use. Digital imaging processes. Telepathology. While slide imaging. Clinical applications of whole slide imaging. Digital pathology for educational, quality improvement, research and other settings. Forensic digital imaging.
Publisher:
ISBN: 9780891896104
Category : Medical informatics
Languages : en
Pages : 304
Book Description
The definitive, complete reference of digital pathology! An extraordinarily comprehensive and complete book for individuals with anything from minimal knowledge to deep, accomplished experience in digital pathology. Easy to read and plainly written, Digital Pathology examines the history and technological evolution of digital pathology, from the birth of scanning technology and telepathology to three-dimensional imaging on large multi-touch displays and computer aided diagnosis. A must-have book for anyone wishing to learn more about and work in this exciting and critical information environment including pathologists, laboratory professionals, students and any other medical practitioners with a particular interest in the history and future of digital pathology. It can also be a useful reference for anyone, medical or non-medical, who have an interest in learning more about the field. Digital pathology is truly a game changer, and this book is a crucial tool for anyone wishing to know more. Subjects discussed in depth include: Static digital imaging; basics and clinical use. Digital imaging processes. Telepathology. While slide imaging. Clinical applications of whole slide imaging. Digital pathology for educational, quality improvement, research and other settings. Forensic digital imaging.
ICIDSSD 2020
Author: M. Afshar Alam
Publisher: European Alliance for Innovation
ISBN: 163190292X
Category : Social Science
Languages : en
Pages : 606
Book Description
The International Conference on ICT for Digital, Smart, and Sustainable Development (ICIDSSD’20) aims to provide an annual platform for the researchers, academicians, and professionals from across the world. ICIDSSD’20, held at Jamia Hamdard, New Delhi, India, is the second international conference of this series of conferences to be held annually. The conference majorly focuses on the recent developments in the areas relating to Information and Communication Technologies and contributing to Sustainable Development. ICIDSSD’20 has attracted research papers pertaining to an array of exciting research areas. The selected papers cover a wide range of topics including but not limited to Sustainable Development, Green Computing, Smart City, Artificial Intelligence, Big Data, Machine Learning, Cloud Computing, IoT, ANN, Cyber Security, and Data Science. Papers have primarily been judged on originality, presentation, relevance, and quality of work. Papers that clearly demonstrate results have been preferred. We thank our esteemed authors for having shown confidence in us and entrusting us with the publication of their research papers. The success of the conference would not have been possible without the submission of their quality research works. We thank the members of the International Scientific Advisory Committee, Technical Program Committee and members of all the other committees for their advice, guidance, and efforts. Also, we are grateful to our technical partners and sponsors, viz. HNF, EAI, ISTE, AICTE, IIC, CSI, IETE, Department of Higher Education, MHRD and DST for sponsorship and assistance.
Publisher: European Alliance for Innovation
ISBN: 163190292X
Category : Social Science
Languages : en
Pages : 606
Book Description
The International Conference on ICT for Digital, Smart, and Sustainable Development (ICIDSSD’20) aims to provide an annual platform for the researchers, academicians, and professionals from across the world. ICIDSSD’20, held at Jamia Hamdard, New Delhi, India, is the second international conference of this series of conferences to be held annually. The conference majorly focuses on the recent developments in the areas relating to Information and Communication Technologies and contributing to Sustainable Development. ICIDSSD’20 has attracted research papers pertaining to an array of exciting research areas. The selected papers cover a wide range of topics including but not limited to Sustainable Development, Green Computing, Smart City, Artificial Intelligence, Big Data, Machine Learning, Cloud Computing, IoT, ANN, Cyber Security, and Data Science. Papers have primarily been judged on originality, presentation, relevance, and quality of work. Papers that clearly demonstrate results have been preferred. We thank our esteemed authors for having shown confidence in us and entrusting us with the publication of their research papers. The success of the conference would not have been possible without the submission of their quality research works. We thank the members of the International Scientific Advisory Committee, Technical Program Committee and members of all the other committees for their advice, guidance, and efforts. Also, we are grateful to our technical partners and sponsors, viz. HNF, EAI, ISTE, AICTE, IIC, CSI, IETE, Department of Higher Education, MHRD and DST for sponsorship and assistance.
Global Trends 2040
Author: National Intelligence Council
Publisher: Cosimo Reports
ISBN: 9781646794973
Category :
Languages : en
Pages : 158
Book Description
"The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.
Publisher: Cosimo Reports
ISBN: 9781646794973
Category :
Languages : en
Pages : 158
Book Description
"The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.
Artificial Intelligence in Drug Design
Author: Alexander Heifetz
Publisher: Humana
ISBN: 9781071617892
Category : Medical
Languages : en
Pages : 0
Book Description
This volume looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Artificial Intelligence in Drug Design is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists and drug designers.
Publisher: Humana
ISBN: 9781071617892
Category : Medical
Languages : en
Pages : 0
Book Description
This volume looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Artificial Intelligence in Drug Design is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists and drug designers.
The Role of Telehealth in an Evolving Health Care Environment
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309262054
Category : Medical
Languages : en
Pages : 159
Book Description
In 1996, the Institute of Medicine (IOM) released its report Telemedicine: A Guide to Assessing Telecommunications for Health Care. In that report, the IOM Committee on Evaluating Clinical Applications of Telemedicine found telemedicine is similar in most respects to other technologies for which better evidence of effectiveness is also being demanded. Telemedicine, however, has some special characteristics-shared with information technologies generally-that warrant particular notice from evaluators and decision makers. Since that time, attention to telehealth has continued to grow in both the public and private sectors. Peer-reviewed journals and professional societies are devoted to telehealth, the federal government provides grant funding to promote the use of telehealth, and the private technology industry continues to develop new applications for telehealth. However, barriers remain to the use of telehealth modalities, including issues related to reimbursement, licensure, workforce, and costs. Also, some areas of telehealth have developed a stronger evidence base than others. The Health Resources and Service Administration (HRSA) sponsored the IOM in holding a workshop in Washington, DC, on August 8-9 2012, to examine how the use of telehealth technology can fit into the U.S. health care system. HRSA asked the IOM to focus on the potential for telehealth to serve geographically isolated individuals and extend the reach of scarce resources while also emphasizing the quality and value in the delivery of health care services. This workshop summary discusses the evolution of telehealth since 1996, including the increasing role of the private sector, policies that have promoted or delayed the use of telehealth, and consumer acceptance of telehealth. The Role of Telehealth in an Evolving Health Care Environment: Workshop Summary discusses the current evidence base for telehealth, including available data and gaps in data; discuss how technological developments, including mobile telehealth, electronic intensive care units, remote monitoring, social networking, and wearable devices, in conjunction with the push for electronic health records, is changing the delivery of health care in rural and urban environments. This report also summarizes actions that the U.S. Department of Health and Human Services (HHS) can undertake to further the use of telehealth to improve health care outcomes while controlling costs in the current health care environment.
Publisher: National Academies Press
ISBN: 0309262054
Category : Medical
Languages : en
Pages : 159
Book Description
In 1996, the Institute of Medicine (IOM) released its report Telemedicine: A Guide to Assessing Telecommunications for Health Care. In that report, the IOM Committee on Evaluating Clinical Applications of Telemedicine found telemedicine is similar in most respects to other technologies for which better evidence of effectiveness is also being demanded. Telemedicine, however, has some special characteristics-shared with information technologies generally-that warrant particular notice from evaluators and decision makers. Since that time, attention to telehealth has continued to grow in both the public and private sectors. Peer-reviewed journals and professional societies are devoted to telehealth, the federal government provides grant funding to promote the use of telehealth, and the private technology industry continues to develop new applications for telehealth. However, barriers remain to the use of telehealth modalities, including issues related to reimbursement, licensure, workforce, and costs. Also, some areas of telehealth have developed a stronger evidence base than others. The Health Resources and Service Administration (HRSA) sponsored the IOM in holding a workshop in Washington, DC, on August 8-9 2012, to examine how the use of telehealth technology can fit into the U.S. health care system. HRSA asked the IOM to focus on the potential for telehealth to serve geographically isolated individuals and extend the reach of scarce resources while also emphasizing the quality and value in the delivery of health care services. This workshop summary discusses the evolution of telehealth since 1996, including the increasing role of the private sector, policies that have promoted or delayed the use of telehealth, and consumer acceptance of telehealth. The Role of Telehealth in an Evolving Health Care Environment: Workshop Summary discusses the current evidence base for telehealth, including available data and gaps in data; discuss how technological developments, including mobile telehealth, electronic intensive care units, remote monitoring, social networking, and wearable devices, in conjunction with the push for electronic health records, is changing the delivery of health care in rural and urban environments. This report also summarizes actions that the U.S. Department of Health and Human Services (HHS) can undertake to further the use of telehealth to improve health care outcomes while controlling costs in the current health care environment.