Computational Methods for Understanding Bacterial and Archaeal Genomes PDF Download
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Author: Ying Xu
Publisher: World Scientific
ISBN: 1860949827
Category : Medical
Languages : en
Pages : 494
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Book Description
Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.
Author: Ying Xu
Publisher: World Scientific
ISBN: 1860949827
Category : Medical
Languages : en
Pages : 494
Get Book Here
Book Description
Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.
Author: Ying Xu
Publisher: Imperial College Press
ISBN: 1860949835
Category : Science
Languages : en
Pages : 494
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Book Description
Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.
Author: Eberhard Voit
Publisher: Garland Science
ISBN: 1351332937
Category : Computers
Languages : en
Pages : 783
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Book Description
A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.
Author: Hon Wai Leong
Publisher: Imperial College Press
ISBN: 1848162529
Category : Science
Languages : en
Pages : 145
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Book Description
Research in the field of gene regulation is evolving rapidly in the ever-changing scientific environment. Advances in microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics. The study of genomic binding locations of transcription factors has enabled a more comprehensive modeling of regulatory networks. In addition, complete genomic sequences and comparison of numerous related species have demonstrated the conservation of non-coding DNA sequences, which often provide evidence for cis-regulatory binding sites. Systematic methods to decipher the regulatory mechanism are also crucial for corroborating these regulatory networks; key to these methods are motif discovery algorithms that can help predict cis-regulatory elements. These DNA-motif discovery programs are becoming more sophisticated and are beginning to leverage evidence from comparative genomics. These topics and more were discussed at the 3rd Annual RECOMB Workshop on Regulatory Genomics, which brought together more than 90 attendees and included about 22 excellent talks from leading researchers in the field. This proceedings volume contains ten selected, original manuscripts that were presented during the workshop.
Author: Ziling Wang
Publisher: World Scientific
ISBN: 1848169264
Category : Science
Languages : en
Pages : 304
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Book Description
This is a handbook of methods and protocols for biologists. It aimed at undergraduate, graduate students and researchers originally trained in biological or medical sciences who need to know how to access the data archives of genomes, proteins, metabolites, gene expression profiles and the questions these data and tools can answer. For each chapter, the conceptual and experimental background is provided, together with specific guidelines for handling raw data, including preprocessing and analysis.The content is structured into three parts. Part one introduces basic knowledge about popular bioinformatics tools, databases and web resources. Part two presents examples of omics bioinformatics applications. Part three provides basic statistical analysis skills and programming skills needed to handle and analyze omics datasets.
Author: Dong Xu
Publisher: World Scientific
ISBN: 1908978716
Category : Science
Languages : en
Pages : 246
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Book Description
Many biological systems and objects are intrinsically fuzzy as their properties and behaviors contain randomness or uncertainty. In addition, it has been shown that exact or optimal methods have significant limitation in many bioinformatics problems. Fuzzy set theory and fuzzy logic are ideal to describe some biological systems/objects and provide good tools for some bioinformatics problems. This book comprehensively addresses several important bioinformatics topics using fuzzy concepts and approaches, including measurement of ontological similarity, protein structure prediction/analysis, and microarray data analysis. It also reviews other bioinformatics applications using fuzzy techniques./a
Author: Syed Faraz Hasan
Publisher: Springer
ISBN: 3319640577
Category : Technology & Engineering
Languages : en
Pages : 196
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Book Description
This new edition continues to focus on the nuts and bolts of wireless network access for devices on board vehicles. It has been updated to reflect on the most recent trends in the broad domain of Intelligent Transport Systems. It covers 802.11ac – a recent standard that is very useful in context where a large amount of information is to be sent in a limited time window. The new edition includes a thorough revision of the 'Vehicular Communication: Issues and Standards' chapter, with new citations and a new subsection on security. The new edition also cites numerous fresh research works to give readers an updated overview of the field. An update on the time delay incurred by applications that always run in the background (Skype, etc) is also covered. The 'Future Directions and Research Ideas' chapter is also largely re-written. An entirely new chapter on D2D communication keeping in view the vehicular context has been added in this edition. This volume will be a useful addition to the libraries for both the students of wireless communication and those studying applied probability.
Author: Syed Faraz Hasan
Publisher: Springer Science & Business Media
ISBN: 1461432723
Category : Technology & Engineering
Languages : en
Pages : 157
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Book Description
Focusing on the nuts and bolts of wireless network access for computers on board vehicles, this volume shows how in-car computerization now does much more than merely act as a glorified map-reader. Wireless communication is transforming road travel in ways previously undreamt of, allowing vehicles to “talk” to a wider network and monitor road conditions, potential delays and traffic congestion, all automatically. Toll payments can be made without opening the driver’s window on a cold day, while vehicles might themselves take active steps to avoid collisions. It is the connection between on-board computers and wireless access points, ubiquitous in most cities now, that is a key area of research. Moving vehicles transfer their communications to new points as they progress, and this causes delays, known as “handover latency”. In this book, new stochastic models are developed to map the disruption when connecting to 802.11 WLAN points. It details the application of stochastic tools to analyzing communication networks, as well as previous literature on handover latency and relevant mathematical modeling. Finally, it presents a scheme for monitoring traffic congestion using WLAN connectivity. This volume will be a useful addition to the libraries both of wireless communication students and those studying probability theory.
Author:
Publisher:
ISBN:
Category : Biology
Languages : en
Pages : 664
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Book Description
Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482
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Book Description
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
