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Author: Edison T. Liu
Publisher: Academic Press
ISBN: 0080919839
Category : Science
Languages : en
Pages : 450
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Book Description
Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. - Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine - Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable - Includes a thorough discussion of the applications of quantitative principles to biomedical problems
Author: Edison T. Liu
Publisher: Academic Press
ISBN: 0080919839
Category : Science
Languages : en
Pages : 450
Get Book Here
Book Description
Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. - Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine - Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable - Includes a thorough discussion of the applications of quantitative principles to biomedical problems
Author:
Publisher: Springer
ISBN: 9780387758886
Category : Science
Languages : en
Pages : 10398
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Book Description
This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Author: Doug Fisher
Publisher: Springer Science & Business Media
ISBN: 1461224047
Category : Mathematics
Languages : en
Pages : 444
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Book Description
Ten years ago Bill Gale of AT&T Bell Laboratories was primary organizer of the first Workshop on Artificial Intelligence and Statistics. In the early days of the Workshop series it seemed clear that researchers in AI and statistics had common interests, though with different emphases, goals, and vocabularies. In learning and model selection, for example, a historical goal of AI to build autonomous agents probably contributed to a focus on parameter-free learning systems, which relied little on an external analyst's assumptions about the data. This seemed at odds with statistical strategy, which stemmed from a view that model selection methods were tools to augment, not replace, the abilities of a human analyst. Thus, statisticians have traditionally spent considerably more time exploiting prior information of the environment to model data and exploratory data analysis methods tailored to their assumptions. In statistics, special emphasis is placed on model checking, making extensive use of residual analysis, because all models are 'wrong', but some are better than others. It is increasingly recognized that AI researchers and/or AI programs can exploit the same kind of statistical strategies to good effect. Often AI researchers and statisticians emphasized different aspects of what in retrospect we might now regard as the same overriding tasks.
Author: Franois Kps
Publisher: World Scientific
ISBN: 981270695X
Category : Science
Languages : en
Pages : 531
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Book Description
This volume presents a timely and comprehensive overview of biological networks at all organization levels in the spirit of the complex system approach. It discusses the transversal issues and fundamental principles as well as the overall structure, dynamics, and modeling of a wide array of biological networks at the molecular, cellular, and population levels. Anchored in both empirical data and a strong theoretical background, the book therefore lends valuable credence to the complex systems approach.
Author: Paulo J.G. Lisboa
Publisher: Springer Science & Business Media
ISBN: 9781852330057
Category : Computers
Languages : en
Pages : 314
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Book Description
This volume provides a state-of-the-art survey of artificial neural network applications in biomedical diagnosis, laboratory data analysis and related practical areas. It looks at biomedical applications which involve customising neural network technology to resolve specific difficulties with data processing, and deals with applications relating to particular aspects of clinical practice and laboratory or medically-related analysis. Each chapter is self-contained with regard to the technology used, covering important technical points and implementation issues like the design of user interfaces and hardware/software platforms. Artificial Neural Networks in Biomedicine will be of interest to computer scientists and neural network practitioners who want to extend their knowledge of issues relevant to biomedical applications, developers of clinical computer systems, and medical researchers looking for new methods and computational tools.
Author: G. Rzevski
Publisher: WIT Press
ISBN: 1784663670
Category : Mathematics
Languages : en
Pages : 174
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Book Description
Composed of selected research papers, this book brings together new developments and processes for managing complexity. The included works originate from renowned complexity thinkers, well established practitioners and new researchers in the area of complexity and detail issues of common interest.
Author: Dietmar P.F. Möller
Publisher: Springer Science & Business Media
ISBN: 1441986146
Category : Computers
Languages : en
Pages : 206
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Book Description
This book presents a collection of invited contributions, each reflecting an area of biomedicine in which simulation techniques have been successfully applied. Thus, it provides a state-of-the-art survey of simulation techniques in a variety of biomedical applications. Chapter one presents the conceptual framework for advanced simulations such as parallel processing in biological systems. Chapter two focuses on structured biological modeling based on the bond graph method. This is followed by an up-to-date account of advanced simulation of a variety of sophisticated biomedical processes. The authors provide many insights into how computer simulation techniques and tools can be applied to research problems in biomedicine. The idea for this book arose out of the daily work by experts in their field and reflects developing areas. Therefore, I think the material is timely and hope that the work described will be an encouragement for others. It is the objective of this book to present advanced simulation techniques in biomedicine and outline current research, as well as to point out open problems, in this dynamic field. Finally, I wish to express my thanks to those colleagues who have made this book possible with their contributions.
Author: G. Rzevski
Publisher: WIT Press
ISBN: 1784662356
Category : Computers
Languages : en
Pages : 261
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Book Description
Containing papers presented at the 2016 New Forest Conference on Complex Systems, this multi-disciplinary book presents new approaches for resolving complex issues that cannot be resolved using conventional mathematical or software models. Complex Systems occur in an infinite variety of problems encompassing fields as diverse as economics, the environment, humanities, social and political sciences, physical sciences and engineering. The papers in the book cover such topics as: Complex business processes; Supply chain complexity; Complex adaptive software; Management of complexity; Complexity in social systems; Complexity in engineering; Complex issues in biological and medical sciences; Complex energy systems Complexity and evolution.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309089123
Category : Medical
Languages : en
Pages : 297
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Book Description
The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems. Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies' Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.
Author: Thomas Deisboeck
Publisher: Springer Science & Business Media
ISBN: 0387335323
Category : Medical
Languages : en
Pages : 857
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Book Description
Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
