Combinatorics of Genome Rearrangements PDF Download
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Author:
Publisher:
ISBN: 9780262258180
Category : Combinatorial analysis
Languages : en
Pages : 288
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Book Description
A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically orientated but offering biological explanations when required, this volume offers the first comprehensive survey of a rapidly expanding application of combinatorial optimization.
Author: Guillaume Fertin
Publisher: MIT Press
ISBN: 0262062828
Category : Combinatorial analysis
Languages : en
Pages : 305
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Book Description
A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required. From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.
Author:
Publisher:
ISBN: 9780262258180
Category : Combinatorial analysis
Languages : en
Pages : 288
Get Book Here
Book Description
A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically orientated but offering biological explanations when required, this volume offers the first comprehensive survey of a rapidly expanding application of combinatorial optimization.
Author: Niklas Eriksen
Publisher:
ISBN:
Category :
Languages : en
Pages : 43
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Book Description
Author: Adriana Muñoz
Publisher:
ISBN:
Category : University of Ottawa theses
Languages : en
Pages : 206
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Book Description
Author: Eric Tannier
Publisher: Springer
ISBN: 3642161812
Category : Science
Languages : en
Pages : 312
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Book Description
The complexity of genome evolution has given birth to exciting challenges for computational biologists. A various range of algorithmic, statistical, mathem- ical techniques to elucidate the histories of molecules are developed each year and many are presented at the RECOMB satellite workshop on Comparative Genomics. It is a place where scientists working on all aspects of comparative genomics can share ideas on the development of tools and their application to relevant questions. This volume contains the papers presented at RECOMB-CG 2010, held on October 9–11 in Ottawa. The ?eld is still ?ourishing as seen from the papers presented this year: many developments enrich the combinatorics of genome rearrangements, while gene order phylogenies are becoming more and more - curate, thanks to a mixing of combinatorial and statistical principles, associated with rapid and thoughtful heuristics. Several papers tend to re?ne the models of genome evolution, and more and more genomic events can be modeled, from single nucleotide substitutions in whole genome alignments to large structural mutations or horizontal gene transfers.
![Algorithms for Phylogenetic Tree Reconstruction Based on Genome Rearrangements [microform] PDF](https://books.google.com/books/content/images/frontcover/iRkXNAEACAAJ?fife=w80-h100)
Author: Bourque, Guillaume
Publisher: Ann Arbor, Mich. : University Microfilms International
ISBN:
Category :
Languages : en
Pages : 190
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Book Description
Author: Zheng Fu
Publisher:
ISBN:
Category : Gene mapping
Languages : en
Pages : 282
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Book Description
Author:
Publisher: Academic Press
ISBN: 0128144300
Category : Science
Languages : en
Pages : 610
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Book Description
Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. Contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability Documents cutting edge methods
Author: Andreas Dress
Publisher: Cambridge University Press
ISBN: 113950438X
Category : Mathematics
Languages : en
Pages : 277
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Book Description
Phylogenetic combinatorics is a branch of discrete applied mathematics concerned with the combinatorial description and analysis of phylogenetic trees and related mathematical structures such as phylogenetic networks and tight spans. Based on a natural conceptual framework, the book focuses on the interrelationship between the principal options for encoding phylogenetic trees: split systems, quartet systems and metrics. Such encodings provide useful options for analyzing and manipulating phylogenetic trees and networks, and are at the basis of much of phylogenetic data processing. This book highlights how each one provides a unique perspective for viewing and perceiving the combinatorial structure of a phylogenetic tree and is, simultaneously, a rich source for combinatorial analysis and theory building. Graduate students and researchers in mathematics and computer science will enjoy exploring this fascinating new area and learn how mathematics may be used to help solve topical problems arising in evolutionary biology.
Author: D. Sankoff
Publisher: Springer Science & Business Media
ISBN: 9780792365846
Category : Medical
Languages : en
Pages : 586
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Book Description
A comprehensive account of genomic rearrangement, focusing on the mechanisms of inversion, translocation, gene and genome duplication and gene transfer and on the patterns that result from them in comparative maps. Includes analyses of genomic sequences in organelles, prokaryotes and eukaryotes as well as comparative maps of the nuclear genomes in higher plants and animals. The book showcases a variety of algorithmic and statistical approaches to rearrangement and map data.
