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Author: W. Schmiegel
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 318
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Book Description
Colorectal cancer is one of the most common causes of tumour-associated death in Western countries, and its incidence has been increasing in recent decades. The most important determinant for the course of the disease is tumour stage at the time of diagnosis. The detection of molecular changes in tumour tissue and in benign adenomatous polyps has improved our knowledge of colorectal carcinogenesis. Diseases with a high risk for malignant transformation, as well as family predisposition as an independent risk factor, have been identified. Furthermore, dietary and environmental factors, together with the intake of aspirin and other NSAIDs, influence tumor development. This implies new ways of specific testing for early diagnosis and new prevention strategies based on endoscopy and drug therapy. The main topics of this book, the proceedings of the international Falk Symposium No. 109, held in Titisee, Germany, on October 14-15, 1998, are molecular mechanisms, premalignant state and prevention. State-of-the-art chapters deliver the latest scientific developments on every topic, followed by more detailed chapters on specific items.
Author: W. Schmiegel
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 318
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Book Description
Colorectal cancer is one of the most common causes of tumour-associated death in Western countries, and its incidence has been increasing in recent decades. The most important determinant for the course of the disease is tumour stage at the time of diagnosis. The detection of molecular changes in tumour tissue and in benign adenomatous polyps has improved our knowledge of colorectal carcinogenesis. Diseases with a high risk for malignant transformation, as well as family predisposition as an independent risk factor, have been identified. Furthermore, dietary and environmental factors, together with the intake of aspirin and other NSAIDs, influence tumor development. This implies new ways of specific testing for early diagnosis and new prevention strategies based on endoscopy and drug therapy. The main topics of this book, the proceedings of the international Falk Symposium No. 109, held in Titisee, Germany, on October 14-15, 1998, are molecular mechanisms, premalignant state and prevention. State-of-the-art chapters deliver the latest scientific developments on every topic, followed by more detailed chapters on specific items.
Author: American Institute for Cancer Resea
Publisher: Springer Science & Business Media
ISBN: 1461541492
Category : Medical
Languages : en
Pages : 169
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Book Description
The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm.
Author: Kjetil Søreide
Publisher:
ISBN: 9781604567144
Category : Colon (Anatomy)
Languages : en
Pages : 0
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Book Description
The understanding of the mechanisms that explain the initiation and early evolution of colorectal cancer is evolving. This should facilitate the development of new approaches to effective prevention and intervention. Over the past years, deficiencies in the current adenoma-carcinoma model for colorectal cancer, in which APC mutation is placed at the point of initiation, have been suggested. Several pathways through which cancer may develop seem to exist, such as 'chromosomal instability' (CIN), 'microsatellite instability' (MSI), and most recently the 'serrated pathway' involving epigenetic changes. Parallel to discoveries in molecular pathways are the increased awareness of early and precursor features of the colorectal mucosa detected and treated by endoscopic and minimal-invasive techniques. Thus, new staging and classification systems have been developed to guide the clinician in diagnosis and choice of treatment. This book sets focus on selected clinical and molecular aspects of colorectal precursor lesions; from the endoscopically detected colorectal polyp, major molecular mechanisms, and aspects of protease-systems in colorectal cancer development. Future research on colorectal cancer needs to be stratified according to the appropriate clinical features and their associated genetic pathways involved in order to further explore important molecular mechanisms and clinicopathological consequences of chromosomal, microsatellite and epigenetic mechanisms.
Author: Shilpa S. Dhar
Publisher: Frontiers Media SA
ISBN: 2832506410
Category : Medical
Languages : en
Pages : 201
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Book Description
Author: Kevin M. Haigis, Ph.D.
Publisher: Springer Science & Business Media
ISBN: 146148412X
Category : Medical
Languages : en
Pages : 319
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Book Description
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Author:
Publisher:
ISBN:
Category : Colon (Anatomy)
Languages : en
Pages : 165
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Book Description
Author: American Institute for Cancer Research
Publisher: Springer
ISBN: 9781461541509
Category : Medical
Languages : en
Pages : 165
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Book Description
The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Masato Kusunoki
Publisher: Springer
ISBN: 4431555226
Category : Medical
Languages : en
Pages : 151
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Book Description
As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on the treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the point of view of expert surgeons.
Author: Elizabeth K. Weisburger
Publisher: Springer Science & Business Media
ISBN: 9400925263
Category : Medical
Languages : en
Pages : 210
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Book Description
but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
