Clinical Statistics: Introducing Clinical Trials, Survival Analysis, and Longitudinal Data Analysis PDF Download
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Author: Olga Korosteleva
Publisher: Jones & Bartlett Learning
ISBN: 0763758507
Category : Mathematics
Languages : en
Pages : 129
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Book Description
Clinical Statistics: Introducing Clinical Trials, Survival Analysis, and Longitudinal Data Analysis provides the mathematic background necessary for students preparing for a career as a statistician in the biomedical field. The manual explains the steps a clinical statistician must take in clinical trials from protocol writing to subject randomization, to data monitoring, and on to writing a final report to the FDA. All of the necessary fundamentals of statistical analysis: survival and longitudinal data analysis are included. SAS procedures are explained with simple examples and the mathematics behind these SAS procedures are covered in detail with the statistical software program SAS which is implemented throughout the text. Complete codes are given for every example found in the text. The exercises featured throughout the guide are both theoretical and applied making it appropriate for those moving on to different clinical settings. Students will find Clinical Statistics to be a handy lab reference for coursework and in their future careers.
Author: Olga Korosteleva
Publisher: Jones & Bartlett Learning
ISBN: 0763758507
Category : Mathematics
Languages : en
Pages : 129
Get Book
Book Description
Clinical Statistics: Introducing Clinical Trials, Survival Analysis, and Longitudinal Data Analysis provides the mathematic background necessary for students preparing for a career as a statistician in the biomedical field. The manual explains the steps a clinical statistician must take in clinical trials from protocol writing to subject randomization, to data monitoring, and on to writing a final report to the FDA. All of the necessary fundamentals of statistical analysis: survival and longitudinal data analysis are included. SAS procedures are explained with simple examples and the mathematics behind these SAS procedures are covered in detail with the statistical software program SAS which is implemented throughout the text. Complete codes are given for every example found in the text. The exercises featured throughout the guide are both theoretical and applied making it appropriate for those moving on to different clinical settings. Students will find Clinical Statistics to be a handy lab reference for coursework and in their future careers.
Author: Elisa T. Lee
Publisher: John Wiley & Sons
ISBN: 1118593057
Category : Mathematics
Languages : en
Pages : 512
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Book Description
Praise for the Third Edition “. . . an easy-to read introduction to survival analysiswhich covers the major concepts and techniques of thesubject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments,Statistical Methods for Survival Data Analysis, FourthEdition continues to deliver a comprehensive introduction tothe most commonly-used methods for analyzing survival data.Authored by a uniquely well-qualified author team, the FourthEdition is a critically acclaimed guide to statistical methods withapplications in clinical trials, epidemiology, areas of business,and the social sciences. The book features many real-world examplesto illustrate applications within these various fields, althoughspecial consideration is given to the study of survival data inbiomedical sciences. Emphasizing the latest research and providing the mostup-to-date information regarding software applications in thefield, Statistical Methods for Survival Data Analysis, FourthEdition also includes: Marginal and random effect models for analyzing correlatedcensored or uncensored data Multiple types of two-sample and K-sample comparisonanalysis Updated treatment of parametric methods for regression modelfitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of thepresented material Statistical Methods for Survival Data Analysis is anideal text for upper-undergraduate and graduate-level courses onsurvival data analysis. The book is also an excellent resource forbiomedical investigators, statisticians, and epidemiologists, aswell as researchers in every field in which the analysis ofsurvival data plays a role.
Author: Ettore Marubini
Publisher: John Wiley & Sons
ISBN: 9780470093412
Category : Mathematics
Languages : en
Pages : 436
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Book Description
A practical guide to methods of survival analysis for medical researchers with limited statistical experience. Methods and techniques described range from descriptive and exploratory analysis to multivariate regression methods. Uses illustrative data from actual clinical trials and observational studies to describe methods of analysing and reporting results. Also reviews the features and performance of statistical software available for applying the methods of analysis discussed.
Author: Thomas D. Cook
Publisher: CRC Press
ISBN: 1420009966
Category : Mathematics
Languages : en
Pages : 452
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Book Description
Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors' collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various stati
Author: Wan Tang
Publisher: Springer Science & Business Media
ISBN: 1461443229
Category : Medical
Languages : en
Pages : 254
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Book Description
This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. The intent of the book is to provide an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out analyses. While classic topics such as survival data analysis, analysis of diagnostic test data and assessment of measurement reliability are well known and covered in depth by available topic-specific texts, this volume serves a different purpose: it provides a quick introduction to each topic for self-learning, particularly for those who have not done any formal coursework on a given topic but must learn it due to its relevance to their multidisciplinary research. In addition, the chapters on these classic topics will reflect issues particularly relevant to modern clinical trials such as longitudinal designs and new methods for analyzing data from such study designs. The coverage of these topics provides a quick introduction to these important statistical issues and methods for addressing them. As with the classic topics, this part of the volume on modern topics will enable researchers to grasp the statistical methods for addressing these emerging issues underlying modern clinical trials and to apply them to their research studies.
Author: David E. Matthews
Publisher: Basel : Karger
ISBN:
Category : Medical
Languages : en
Pages : 220
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Book Description
Since the last edition of this book was published, major developments in computer technology have affected both the practice of medicine and the methods of analyzing medical data. These advances make the focus of this revised edition - understanding many of the statistical methods that are used in modern medical studies-all the more important. Two new chapters have been added by the authors. One provides readers with an introduction to the analysis of longitudinal data. The other augments previous material concerning the design of clinical trials, exploring topics such as the use of surrogate markers, multiple outcomes, equivalence trials, and the planning of efficacy-toxicity studies. In addition to providing new information and fine-tuning the rest of the book, the authors have reorganized the final six chapters so that the topics build, naturally, on each other. This latest edition is highly recommended both as an excellent introduction to medical statistics and as a valuable tool in explaining the more complex statistical methods and techniques used today.
Author: Craig Mallinckrodt
Publisher: CRC Press
ISBN: 1351737694
Category : Mathematics
Languages : en
Pages : 302
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Book Description
Analyzing Longitudinal Clinical Trial Data: A Practical Guide provides practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine practice.The book, with its example-oriented approach that includes numerous SAS and R code fragments, is an essential resource for statisticians and graduate students specializing in medical research. The authors provide clear descriptions of the relevant statistical theory and illustrate practical considerations for modeling longitudinal data. Topics covered include choice of endpoint and statistical test; modeling means and the correlations between repeated measurements; accounting for covariates; modeling categorical data; model verification; methods for incomplete (missing) data that includes the latest developments in sensitivity analyses, along with approaches for and issues in choosing estimands; and means for preventing missing data. Each chapter stands alone in its coverage of a topic. The concluding chapters provide detailed advice on how to integrate these independent topics into an over-arching study development process and statistical analysis plan.
Author: Mark X. Norleans
Publisher: CRC Press
ISBN: 9780824704674
Category : Mathematics
Languages : en
Pages : 306
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Book Description
"Summarizes graphical analysis, analysis of variance, meta-analysis, and design of comparable treatment groups. Streamlines the analytical techniques for continuous, categorical, longitudinal, and survival data-focusing on generalized linear models, GEEs, and mixed linear models, -ahd highlihgts p-value, and more."
Author: David Collett
Publisher: CRC Press
ISBN: 1000863107
Category : Medical
Languages : en
Pages : 557
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Book Description
Hugely popular textbook on survival analysis for graduate students of statistics and biostatistics, mainly due to its accessibility and breadth of examples. This is a standard course on graduate programs in biostatistics and statistics, and this is one of the most popular textbooks. Updated with modern methods covering Bayesian survival analysis, joint models, and more.
Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1351651145
Category : Mathematics
Languages : en
Pages : 310
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Book Description
Review of the First Edition "The goal of this book, as stated by the authors, is to fill the knowledge gap that exists between developed statistical methods and the applications of these methods. Overall, this book achieves the goal successfully and does a nice job. I would highly recommend it ...The example-based approach is easy to follow and makes the book a very helpful desktop reference for many biostatistics methods."—Journal of Statistical Software Clinical Trial Data Analysis Using R and SAS, Second Edition provides a thorough presentation of biostatistical analyses of clinical trial data with step-by-step implementations using R and SAS. The book’s practical, detailed approach draws on the authors’ 30 years’ experience in biostatistical research and clinical development. The authors develop step-by-step analysis code using appropriate R packages and functions and SAS PROCS, which enables readers to gain an understanding of the analysis methods and R and SAS implementation so that they can use these two popular software packages to analyze their own clinical trial data. What’s New in the Second Edition Adds SAS programs along with the R programs for clinical trial data analysis. Updates all the statistical analysis with updated R packages. Includes correlated data analysis with multivariate analysis of variance. Applies R and SAS to clinical trial data from hypertension, duodenal ulcer, beta blockers, familial andenomatous polyposis, and breast cancer trials. Covers the biostatistical aspects of various clinical trials, including treatment comparisons, time-to-event endpoints, longitudinal clinical trials, and bioequivalence trials.
