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Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470514604
Category : Science
Languages : en
Pages : 348
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Book Description
Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470514604
Category : Science
Languages : en
Pages : 348
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Book Description
Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans.
Author: Charles A. Czeisler
Publisher:
ISBN:
Category : Human physiology
Languages : en
Pages : 692
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Book Description
Author: Urs Albrecht
Publisher: Springer Science & Business Media
ISBN: 1441912622
Category : Science
Languages : en
Pages : 306
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Book Description
With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
Author: Joseph S. Takahashi
Publisher: Springer Science & Business Media
ISBN: 9780306465048
Category : Medical
Languages : en
Pages : 820
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Book Description
The nature of the circadian clocks is described at the molecular, cellular, tissue, and system levels of organization in diverse organisms. The central role of the circadian clock in the regulation of the sleep-wake cycle as well as seasonal rhythms and other cyclical processes is also discussed. The importance of the circadian clock system for human health, safety, performance, and productivity is also reviewed in this volume."--BOOK JACKET.
Author: Mohamed A. El-Esawi
Publisher: BoD – Books on Demand
ISBN: 1789233380
Category : Medical
Languages : en
Pages : 168
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Book Description
Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.
Author: Russell Foster
Publisher: Oxford University Press
ISBN: 0191027464
Category : Science
Languages : en
Pages : 144
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Book Description
The earth's daily rotation affects just about every living creature. From dawn through to dusk, there are changes in light, temperature, humidity, and rainfall. However, these changes are regular, rhythmic and, therefore, predictable. Thus, the near 24 hour circadian rhythm is innate: a genetically programmed clock that essentially ticks of its own accord. This Very Short Introduction explains how organisms can "know" the time and reveals what we now understand of the nature and operation of chronobiological processes. Covering variables such as light, the metabolism, human health, and the seasons, Foster and Kreitzman illustrate how jet lag and shift work can impact on human well-being, and consider circadian rhythms alongside a wide range of disorders, from schizophrenia to obesity. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Author: Derek Chadwick
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 360
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Book Description
This study describes the molecular, genetic, anatomical and neurochemical mechanisms and pathways that operate to control and regulate circadian clock signals in organisms. It also considers the implications of this research for humans.
Author: Raúl Aguilar-Roblero
Publisher: Springer
ISBN: 3319089455
Category : Medical
Languages : en
Pages : 396
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Book Description
Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct “clock genes” pathologies. This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems.. It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology.
Author: S. Michal Jazwinski
Publisher: Springer
ISBN: 3319645439
Category : Medical
Languages : en
Pages : 361
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Book Description
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
Author: Maria Luisa Fanjul-Moles
Publisher:
ISBN: 9788178953298
Category :
Languages : en
Pages : 203
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Book Description
Chronobiology is the study of adaptations evolved at all levels of organization by living organisms to cope with regular geophysical cycles in the environment. The Earth s rotation originates alternation of light and darkness with a 24-h period; this signal allowed primordial organisms to keep track of time, adjust their internal temporal order, and anticipate external time. This capability fostered the development in living matter of endogenous temporal organization of cellular process over an approximately 24-h period. The cellular machinery that generates this ability is known as the biological clock, and its outputs as circadian rhythms. Such clocks can be found in nearly all organisms, from simple bacteria to insects, mammals, and of course, humans. The selective advantage conferred to all organisms by the biological clock comprises coordination of molecular, physiological, and behavioral processes, so as to ensure its occurrence during the daily cycle s optimal time. When organisms are maintained in an environment with strong time signals (zeitgebers) such as the light-dark cycle, each of their circadian rhythms establishes a stable relationship with each other and with the external cycle, and becomes an entrained system. Different species and different individuals within each species are coupled with their own typical phases to the natural 24-h cycle. Thus, time is embedded in our genes, and circadian clocks have emerged several times during evolution as a result of convergence to meet a common need. And although key proteins are not conserved, all clocks known to date in eukaryotes involve transcriptional-translational feedback loops. Over the last decades, chronobiology has expanded enormously, is emerging independently in many fields, and it is one of the most interdisciplinary fields in biology. While it has not been easy to understand how a biological clock works in an organism, research with different models from single-cell organisms to complex multicellular plants and animals have provided us insight concerning the ticking of the clock. Identification of circadian rhythms in biochemical and behavioral parameters in different unicellular organisms, localization of different oscillators in combination with behavioral outputs markers by neurobiological techniques in insects and mammals, as well as molecular genetics that has led to identification and cloning of clock genes in several species including humans have rendered chronobiology a diverse and dynamic discipline, with not only biological relevance but also important social and medical implications. Our goal in editing this book was to provide a comparative view of our current knowledge regarding circadian rhythms and clocks at different phylogenetic levels. The authors contributing to this volume review both circadian molecules and mechanisms in representative groups ranging from simple organisms as unicells to complex ones such as invertebrates and non-mammal and mammal vertebrates. The book reflects and is a token of different approaches to the field, such as regulation molecules and their biochemical pathways involved in either circadian or exogenous aspects of the rhythmic process and its regulation in photoautotrophic unicells and the neurobiological and molecular bases of circadian oscillators in some invertebrates and vertebrates. A number of works are focused in the importance of environmental, social, and nutrient temporal signals as synchronizing agents in insects and in different vertebrate models. These reviews are not only centered on the adult organism at the integrative level, but also provide an ontogenetic view at behavioral, physiological, and molecular levels. Furthermore, they supply evidence on several organs as potential sources of circadian signaling for different vertebrate groups, which indicates multioscillatory circadian systems similar to those proposed for some invertebrates. In Chapter 1, Rüdiger Hardeland revises the importance of tryptophan metabolic pathways in two unicells, Euglena gracilis, and the dinoflagellate, Lingulodinium polyedrum. Barbara-Ann Battelle, in Chapter 2, reviews and describes current knowledge of the circadian system of a Chelicerata, Limulus polyphemus, visual inputs into the central clock, and efferent pathways of the clock to the eyes, in addition to the molecular mechanisms underlying these processes. In Chapter 3, María Elena Durán-Lizárraga et al. review the role of different crustacean neuropeptides in the regulation of several physiological processes, such as those proposed as controlled by the circadian system of decapoda, particularly in crayfish. Claudio R. Lazzari and Teresita C. Insausti examine, in Chapter 4, the importance of circadian rhythms from insect s populations, closely associated with the history of chronobiology and the Pittendrigh pioneering work. Continuing on insects, the concept of the superorganism and the interaction of rhythms at different frequencies in different cohorts of individuals forming a colony is presented in Chapter 5 by Mirian David-Marques and Cintia Etsuko-Yamashita. In dealing with vertebrates, Raquel Carvalho and Luiz Menna-Barreto in Chapter 6 address fish from the phenomenology of circadian rhythms to the description of the underlying multioscillatory system, finally reviewing its ecological and evolutionary relevance of these species as a model. The following chapter (7) by Carolina Escobar et al. offers an integrative view of the so-called food-entrained oscillator in rodents. Then, in Chapter 8 Ivette Caldelas and colleagues provide us with an ontogenetic approach to non-visual entrainment of the circadian system, an alternative view of the food-entrained oscillator, using as a natural model the newborn rabbit. Still in the area of restricted food availability as an entraining signal, in Chapter 9 Adrián Báez-Ruíz et al. provide yet another perspective of this phenomenon, which stresses the role of liver physiology and biochemistry in the regulation of food ingestion and hepatic circadian rhythmicity. Finally, in Chapter 10 Raúl Aguilar-Roblero and colleagues review the role of the rodent suprachiasmatic nuclei as a biological clock for the mammalian circadian system, with emphasis on molecular and cellular aspects involved in the first steps of coding biological time into a signal readable by its neuronal targets. We have attempted to provide a panoramic perspective of the multiple approaches for addressing the study of the circadian system in different organisms. Selection of contributions included certain aspects of circadian rhythms not easily found in other reviews. We are indebted to the enthusiastic response of the entire group of contributors, all distinguished professors from universities from different countries, in achieving publication of this volume. We hope readers will find the text useful and that it will perhaps further promote their interest in this area of biology.
