Chromatographic Separations of Stereoisomers PDF Download
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Author: Rex W. Souter
Publisher: CRC Press
ISBN: 9780849361272
Category : Medical
Languages : en
Pages : 256
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Book Description
Provides current knowledge about separation and interactions of asymmetric molecules, as well as experimental and commercial ma-terials such as columns, instruments, and derivatization reagents. Extensive applications are tabulated by both chromato-graphic technique and compound class, and discussions of recent special topics are useful in planning new work. This unique volume organizes most of the significant, currently available knowledge re-garding the chromatographic separations of stereoisomers. Both diastereomers and the more difficult, controversial area of enan-tiomers are covered in depth with respect to GC, HPLC, and classi-cal chromatographic techniques. Analytical, organic, pharmaceuti-cal, and other chemists as well as pharmacologists and bio-chemists are among those whose work appears in the more than 800 references cite.
Author: Rex W. Souter
Publisher: CRC Press
ISBN: 9780849361272
Category : Medical
Languages : en
Pages : 256
Get Book Here
Book Description
Provides current knowledge about separation and interactions of asymmetric molecules, as well as experimental and commercial ma-terials such as columns, instruments, and derivatization reagents. Extensive applications are tabulated by both chromato-graphic technique and compound class, and discussions of recent special topics are useful in planning new work. This unique volume organizes most of the significant, currently available knowledge re-garding the chromatographic separations of stereoisomers. Both diastereomers and the more difficult, controversial area of enan-tiomers are covered in depth with respect to GC, HPLC, and classi-cal chromatographic techniques. Analytical, organic, pharmaceuti-cal, and other chemists as well as pharmacologists and bio-chemists are among those whose work appears in the more than 800 references cite.
Author: R. W. Souter
Publisher:
ISBN:
Category :
Languages : en
Pages : 241
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Book Description
Stereoisomer separations by gas chromatography. Stereoisomer separations by high performance liquid chromatography. Stereoisomer separations by other chromatographic techniques.
Author: T A Berger
Publisher: Royal Society of Chemistry
ISBN: 1847551602
Category : Science
Languages : en
Pages : 268
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Book Description
Packed Column SFC is the third title to be published in this series and has been produced as a result of the dramatic re-emergence, in the last three years, of packed column instrumentation. This has led to a redefinition of the technique and an urgent need for a practical guide that deals with its subtleties. This book fulfils that need and deals exclusively with packed column SFC. It places the emphasis on understanding the underlying chemistry in order to perform rapid, systematic optimizations and provides many practical tips to help the new user avoid problems unique to SFC. It also proposes a detailed scheme for method development and provides lists of prioritized guidelines. The book clears up some of the confusion that surrounds the analytical use of supercritical fluids and assists the user in understanding the power and utility of this technique. Detailed chapters cover the most promising new application areas for packed column SFC, which are often overlooked in the mainstream chromatography literature. Like the other books in this popular series, Packed Column SFC will prove an invaluable guide and is essential reading for graduates, postgraduates and researchers with interests in pharmaceuticals, agricultural chemistry, small polar drug molecules, chiral analysis, environmental chemistry, and chromatography/instrumentation.
Author: w Lough
Publisher: Springer Science & Business Media
ISBN: 940090861X
Category : Science
Languages : en
Pages : 278
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Book Description
While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.
Author: Gerald Gübitz
Publisher: Springer Science & Business Media
ISBN: 1592596487
Category : Science
Languages : en
Pages : 427
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Book Description
Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.
Author: Colin F. Poole
Publisher: Elsevier
ISBN: 0128093676
Category : Science
Languages : en
Pages : 574
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Book Description
Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated. Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level. - Edited and authored by world-leading chromatography experts - Provides comprehensive coverage of SFC in a single source - Extensive referencing facilitates identification of key research developments - More than 200 figures and tables aid in the retention of key concepts
Author: Fumio Toda
Publisher: Springer Science & Business Media
ISBN: 1402023375
Category : Science
Languages : en
Pages : 334
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Book Description
In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Author: C. F. Poole
Publisher: Elsevier
ISBN: 9780444501981
Category : Science
Languages : en
Pages : 940
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Book Description
General concepts in column chromatography -- The column in gas chromatography -- Instrumental aspects of gas chromatography -- The column in liquid chromatography -- Instrumental aspects of liquid chromatography -- Thin-layer chromatography -- Supercritical fluid chromatography -- Capillary-electromigration separation techniques -- Spectroscopic detectors for identification and quantification -- Separation of stereoisomers -- Laboratory-scale preparative chromatography.
Author: Bezhan Chankvetadze
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: G. Subramanian
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 376
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Book Description
This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst
