Introduction to Epigenetics

Introduction to Epigenetics PDF Author: Renato Paro
Publisher: Springer Nature
ISBN: 3030686701
Category : Science
Languages : en
Pages : 215

Get Book Here

Book Description
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Introduction to Epigenetics

Introduction to Epigenetics PDF Author: Renato Paro
Publisher: Springer Nature
ISBN: 3030686701
Category : Science
Languages : en
Pages : 215

Get Book Here

Book Description
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Genetic Analysis

Genetic Analysis PDF Author: Philip Meneely
Publisher:
ISBN: 0198809905
Category : Medical
Languages : en
Pages : 491

Get Book Here

Book Description
Genetic Analysis applies the combined power of molecular biology, genetics, and genomics to explore how the principles of genetics can be used as analytical tools to solve biological problems. This new edition: Illustrates the conceptual basis of key analytical tools with carefully selected examples from a range of model organisms, and encourages the reader to Look beyond the examples to see how these tools can be used to explore a wide range of biological questions, Covers the latest and most powerful experimental tools to provide a state-of-the-art review of the field, giving insights into gene networks and interactions, Includes extended case studies that enable the reader to fully get to grips with how genetic tools can be used to understand biological systems in the real world. New to This Edition: A new chapter on genome editing with focus on the CRISPR-Cas 9 system, New content on the analysis of gene activity using temperature-sensitive mutations and mosaics, Increased coverage of epigenetics, updated with the latest developments in the field, A new Learning feature called "Literature Link," which connects each chapter's content to cutting-edge research. The online resources to accompany Genetic Analysis feature the following material for students and teachers: For students: Practice problems and solutions to test your knowledge of the concepts presented, and help you to master them, Online datasets with which to practise analytic techniques, For registered adopters of the book: Figures from the book in electronic format, ready to download, Journal clubs-suggested papers and discussion questions linked to topics covered in the book. Book jacket.

Chromatin and Chromosomal Protein Research IV

Chromatin and Chromosomal Protein Research IV PDF Author:
Publisher: Academic Press
ISBN: 008085916X
Category : Science
Languages : en
Pages : 465

Get Book Here

Book Description
Chromatin and Chromosomal Protein Research IV

The Regulation of DNA Replication and Transcription

The Regulation of DNA Replication and Transcription PDF Author: Mirko Beljanski, PhD
Publisher: Demos Medical Publishing
ISBN: 1617051829
Category : Medical
Languages : en
Pages : 221

Get Book Here

Book Description
The Regulation of DNA Replication and Transcription explores basic processes of DNA replication and transcription in an effort to identify the mechanisms responsible for the release of genetic information and its role in the regulation of cellular events. Concerned with discovering the fundamental concept that might integrate and explain the wide range of existing lines of evidence, the author reports and interprets the results of experiments conducted in an impressive range of biological systems. Focused on complex mechanisms at the biochemical level, these studies allow analysis of the pathways involved when cells, organs and animal systems react to various trigger molecules derived from both living cells and exogenous sources. These include hormones, RNA, RNA fragments, alkaloids, actinomycin D, and phorbol esters, as well as chemical carcinogens and drugs. Comnining the results of these studies with his own extensive work in this field, the author is able to formulate a uniquely integrative biochemical model for the gene expression, demonstrating that both biological and chemically synthesized molecules can trigger the differential release of information from the DNA and thus influence cell transformation. Apart from its academic significance, the model offers high potential assistance in the search for ways to induce or control the expression of certain genes and, moreover, to promote differentiation of given cells in vitro as well as in situ.

Genome Structure and Function

Genome Structure and Function PDF Author: C. Nicolini
Publisher: Springer Science & Business Media
ISBN: 940115550X
Category : Science
Languages : en
Pages : 340

Get Book Here

Book Description
Proceedings of the NATO Advanced Study Institute on Genome Structure and Function, held in Marciana Marina, Elba, Italy, 13-23 June 1996

International Review of Cytology

International Review of Cytology PDF Author: Kwang W. Jeon
Publisher: Elsevier
ISBN: 0080457762
Category : Science
Languages : en
Pages : 353

Get Book Here

Book Description
International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address the pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesis; morphodynamics of the secretory pathway; aspects of collagen mineralization in hard tissue frmation; the hypoxia-inducible factor and tumor progression along the angiogenic pathway; multidrug resistance in yeast candida; intracellular coupling of interstitial cells of cajal in the digestive tract; and chromatin organization in the mammalian nucleus.

Separation Methods In Microanalytical Systems

Separation Methods In Microanalytical Systems PDF Author: Jorg P. Kutter
Publisher: CRC Press
ISBN: 142002793X
Category : Science
Languages : en
Pages : 896

Get Book Here

Book Description
Focusing on what has been one of the driving forces behind the development of lab-on-a-chip devices, Separation Methods in Microanalytical Systems explores the implementation, realization, and operation of separation techniques and related complex workflows on microfabricated devices. The book details the design, manufacture, and integration of diverse components needed to perform an entire analytical procedure on a single miniaturized device. This volume is valuable reference for scientists and engineers anticipating the demand for function-specific chemical separation systems in biomedical diagnostics, environmental monitoring, and drug discovery applications.

Mechanisms of Gene Regulation

Mechanisms of Gene Regulation PDF Author: Carsten Carlberg
Publisher: Springer
ISBN: 9401777411
Category : Medical
Languages : en
Pages : 219

Get Book Here

Book Description
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.

The Dictionary of Genomics, Transcriptomics and Proteomics

The Dictionary of Genomics, Transcriptomics and Proteomics PDF Author: Guenter Kahl
Publisher: John Wiley & Sons
ISBN: 3527678662
Category : Science
Languages : en
Pages : 2744

Get Book Here

Book Description
Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation

The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation PDF Author: Kenneth Berendzen
Publisher: Bentham Science Publishers
ISBN: 1608054926
Category : Science
Languages : en
Pages : 225

Get Book Here

Book Description
A major goal of integrative research is understanding regulatory networks to such an extent as to allow researchers to model developmental and stress responses. Regulatory networks of living systems include complex and vast interactions between proteins, metabolites, RNA, various signaling molecules and DNA. One aspect of systems biology is understanding the dynamics of protein-DNA interactions affecting gene expression that are caused by transcription factors (TFs) and chromatin remodeling factors. This e-book provides a resource for summarizing current knowledge eukaryotic transcription and explores cis-elements and methods for their analysis, prediction and discovery. The book also presents an overview of exploring gene regulatory networks, chromatin, and miRNAs. Information about state-of-the-art techniques for the determination of TF - cis-element interactions in vivo and in silico give cutting edge insights on how genomic-scale research is being approached. The Analysis of Regulatory DNA provides readers with both the necessary background knowledge and provocative, up-to-date insights aimed at sparking new and vibrant experimental designs for understanding and predicting cis-elements in the eukaryotic genome.