Chiral Triazoles in Anion-binding Catalysis - New Enantioselective Applications, Binding Studies and Mechanistic Insights PDF Download
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Author: Julia Bamberger
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Julia Bamberger
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Olga Garcia-Mancheno
Publisher: John Wiley & Sons
ISBN: 3527348573
Category : Technology & Engineering
Languages : en
Pages : 418
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Book Description
Explores the potential of new types of anion-binding catalysts to solve challenging synthetic problems Anion-Binding Catalysis introduces readers to the use of anion-binding processes in catalytic chemical activation, exploring how this approach can contribute to the future design of novel synthetic transformations. Featuring contributions by world-renowned scientists in the field, this authoritative volume describes the structure, properties, and catalytic applications of anions as well as synthetic applications and practical analytical methods. In-depth chapters are organized by type of catalyst rather than reaction type, providing readers with an accessible overview of the existing classes of effective catalysts. The authors discuss the use of halogens as counteranions, the combination of (thio)urea and squaramide-based anion-binding with other types of organocatalysis, anion-binding catalysis by pnictogen and tetrel bonding, nucleophilic co-catalysis, anion-binding catalysis by pnictogen and tetrel bonding, and more. Helping readers appreciate and evaluate the potential of anion-binding catalysis, this timely book: Illustrates the historical development, activation mode, and importance of anion-binding in chemical catalysis Explains the analytic methods used to determine the anion-binding affinity of the catalysts Describes catalytic and synthetic applications of common NH- and OH-based hydrogen-donor catalysts as well as C-H triazole/triazolium catalysts Covers amino-catalysis involving enamine, dienamine, or iminium activation approaches Discusses new trends in the field of anion-binding catalysis, such as the combination of anion-binding with other types of catalysis Presenting the current state of the field as well as the synthetic potential of anion-binding catalysis in future, Anion-Binding Catalysis is essential reading for researchers in both academia and industry involved in organic synthesis, homogeneous catalysis, and pharmaceutical chemistry.
Author: Qi-Lin Zhou
Publisher: John Wiley & Sons
ISBN: 3527635211
Category : Technology & Engineering
Languages : en
Pages : 670
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Book Description
Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives
Author: Mercedes Zurro de la Fuente
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1847559247
Category : Science
Languages : en
Pages : 403
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The goal of this book is to show the high potential of chiral sulfur-containing ligands to promote numerous asymmetric catalytic transformations. These ligands can now be recognised as real competitors to the more usual phosphorus- or nitrogen-containing ligands.
Author: Jonathan L Sessler
Publisher: Royal Society of Chemistry
ISBN: 1847552471
Category : Science
Languages : en
Pages : 431
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Book Description
Anion recognition plays a critical role in a range of biological processes, and a variety of receptors and carriers can be found throughout the natural world. Chemists working in the area of supramolecular chemistry have created a range of anion receptors, drawing inspiration from nature as well as their own inventive processes. This book traces the origins of anion recognition chemistry as a unique sub-field in supramolecular chemistry while illustrating the basic approaches currently being used to effect receptor design. The combination of biological overview and summary of current synthetic approaches provides a coverage that is both comprehensive and comprehensible. First, the authors detail the key design motifs that have been used to generate synthetic receptors and which are likely to provide the basis for further developments. They also highlight briefly some of the features that are present in naturally occurring anion recognition and transport systems and summarise the applications of anion recognition chemistry. Providing as it does a detailed review for practitioners in the field and a concise introduction to the topic for newcomers, Anion Receptor Chemistry reflects the current state of the art. Fully referenced and illustrated in colour, it is a welcome addition to the literature.
Author: Montserrat Diéguez
Publisher: John Wiley & Sons
ISBN: 3527804072
Category : Technology & Engineering
Languages : en
Pages : 431
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Book Description
An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Author: Gregory Lawrence Hamilton
Publisher:
ISBN:
Category :
Languages : en
Pages : 442
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Book Description
The synthesis of molecules with control over their three-dimensional configuration, known as absolute stereochemistry, is one of the highest goals of synthetic organic chemists. As is so often the case, we strive to reach the facility and efficiency with which Nature achieves this goal. Fortunately, the chemist's imagination allows us to envision nearly unlimited possibilities for new modes of catalysis. In this dissertation, I discuss one branch of asymmetric catalysis that has in a short time progressed from relative obscurity to the forefront of the ever-expanding set of reactions that can be achieved stereoselectively. The basis of this strategy is ion pairing between chiral anionic species and cationic catalysts or intermediates. Chapter 1 discusses the background of the field. In particular, I examine what factors and precedent led the chemical community to recognize the potential of chiral anions to influence reaction stereoselectivity. Many different contributions skirted around the issue before people began to realize that this type of catalysis represents a distinct area that can be uniquely applicable to certain classes of transformations. The suddenness of this recognition is all the more fascinating because chiral cationic species have used in catalysis for some time. Our laboratory's first endeavor in the arena of chiral anions in documented in Chapter 2. This study dovetailed from the group's work in the area of homogeneous gold catalysis. Because many gold catalysts bear a positive charge, we questioned whether a chiral counteranion could be used to induce asymmetry. We were interested in pursuing this strategy because the traditional approach of using chiral ligands bound to the metal was not always sufficient to obtain high enantioselectivity in gold catalyzed reactions. In fact, a chiral phosphate counteranion was found to mediate certain gold-catalyzed reactions with vastly superior degrees of stereoselectivity. Additionally, chiral ligands could work cooperatively with the chiral counteranion to enable particularly challenging asymmetric reactions. After this, we moved from metal-catalyzed reactions to transformations where the chiral anion could form an ion pair with a cationic reaction intermediate. Based on some precedent, we investigated an asymmetric ring opening of meso-aziridinium ions. This transformation is ideal for testing out the ability of chiral anions because the mechanism essentially dictates that any observed asymmetric induction is a result of an ion pair interaction. Furthermore, it is a type of reaction that is not readily amenable to other forms of asymmetric catalysis because the prochiral intermediate does not possess any basic sites. Here again, a chiral phosphate performed well as a chiral counteranion, promoting the ring opening with alcohol nucleophiles in very high enantioselectivity. The method was also modified to enable an asymmetric opening of episulfonium ions. The final chapter documents a number of different efforts aimed at achieving asymmetric substitutions and additions at all-carbon electrophiles. By this time chiral anions were well established as catalysts for additions to several classes of heteroatom-stablized cationic electrophiles. However, additions to carbocations or their functional equivalents were largely out of reach. Our hypothesis was that catalysts capable of interacting covalently with carbon electrophiles could facilitate the asymmetric substitution process. Thus we examined a variety of polarizable anionic and neutral catalyst structures. While our ideas for substitutions of carbon-centered leaving groups were generally unsuccessful in producing a highly enantioselective reaction, the same concepts did lead to an asymmetric addition of amine nucleophiles to dienes. Studies of the mechanism suggested that the catalyst did in fact add covalently to the electrophile before being displaced, thereby validating our original thinking on the subject.
Author: Petri M. Pihko
Publisher: John Wiley & Sons
ISBN: 3527627855
Category : Science
Languages : en
Pages : 395
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Book Description
This first comprehensive overview of the rapidly growing field emphasizes the use of hydrogen bonding as a tool for organic synthesis, especially catalysis. As such, it covers such topics as enzyme chemistry, organocatalysis and total synthesis, all unified by the unique advantages of hydrogen bonding in the construction of complex molecules from simple precursors. Providing everything you need to know, this is a definite must for every synthetic chemist in academia and industry.
Author: Bruce A. Arndtsen
Publisher: Springer Nature
ISBN: 3030438511
Category : Science
Languages : en
Pages : 211
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Book Description
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.
