Chemosensitivity Testing in Oncology PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Chemosensitivity Testing in Oncology PDF full book. Access full book title Chemosensitivity Testing in Oncology by Uwe Reinhold. Download full books in PDF and EPUB format.
Author: Uwe Reinhold
Publisher: Springer Science & Business Media
ISBN: 3642190227
Category : Medical
Languages : en
Pages : 335
Get Book
Book Description
Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.
Author: Uwe Reinhold
Publisher: Springer Science & Business Media
ISBN: 3642190227
Category : Medical
Languages : en
Pages : 335
Get Book
Book Description
Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.
Author: Rosalyn D. Blumenthal
Publisher: Springer Science & Business Media
ISBN: 1592598692
Category : Medical
Languages : en
Pages : 234
Get Book
Book Description
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.
Author: Ossi R. Köchli
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Breast
Languages : en
Pages : 218
Get Book
Book Description
'It will form an important addition to a scientific library and a useful addition to the (contributions series) which should be part of any obstetrics and gynaecology library.' New Zealand Journal of Obstetrics and Gynaecology
Author: Dihua Yu
Publisher: Springer Science & Business Media
ISBN: 0387740392
Category : Medical
Languages : en
Pages : 175
Get Book
Book Description
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.
Author: Rosalyn D. Blumenthal
Publisher: Springer Science & Business Media
ISBN: 1592598897
Category : Medical
Languages : en
Pages : 452
Get Book
Book Description
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.
Author: V. Hofmann
Publisher: Springer Science & Business Media
ISBN: 3642822959
Category : Medical
Languages : en
Pages : 448
Get Book
Book Description
Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity. The advantages of an effective test would lie in obviating the need for testing antineoplastic agents on large cohorts of patients for assessment of drug activity (phase II studies) and in allowing determination of optimal use of anticancer agents (phase III trials). Such an in vitro test could help to better define dose and schedule of drugs preclinically. The additive value of individual drugs could be determined on tumor cells in vitro in order to define the best combination chemotherapy in vivo. Test-directed therapy would avoid unnecessary drug-related morbidity in patients with refractory tumors. Chemotherapy treatment would be more than justified even with side effects if palliation or even prolonged survival could be anticipated as a result. The benefits of predictive drug testing on human tumor cells would extend beyond improvement of individual patient treatment if the testing helped to identify new active agents. This spectrum of benefits to the entire field of oncology pro vides tremendous motivation for the development of such testing. Although a number of chemosensitivity tests have been proposed since the advent of modern anticancer chemotherapy, interest has been renewed by the possibility of cloning human tumor cells on agar plates, with a view to testing drug activity on cells with high pro liferation capacity.
Author: Robert A. Nagourney
Publisher: Turner Publishing Company
ISBN: 1591205506
Category : Health & Fitness
Languages : en
Pages : 264
Get Book
Book Description
By taking a fresh look at some of medicine's most sacrosanct dictates, Dr. Nagourney has found a better, faster, smarter way to treat even the most complex cancers.
Author: Robert E. Bristow
Publisher: CRC Press
ISBN: 0429578857
Category : Medical
Languages : en
Pages : 437
Get Book
Book Description
Updated and expanded, the third edition of Surgery for Ovarian Cancer focuses on essential techniques for the effective management of ovarian cancer. It reflects the most contemporary science and surgical applications for the management of patients with ovarian cancer and related peritoneal surface malignancies. This new edition takes a step-by-step approach and includes new intraoperative photographs and videos illustrating surgical procedures. It is principally devoted to the technical aspects of cytoreductive surgery, with chapters divided according to anatomic region. The chapters cover relevant anatomical considerations, surgical challenges specific to each region, and operative approaches and techniques favored by the authors. The list of contributing authors has been expanded from the previous edition and includes international and world-renowned experts from the fields of gynecologic oncology and surgical oncology. The topics of minimally invasive surgery, secondary cytoreduction, palliative surgery, and postoperative care are also covered in detail. New to the third edition are chapters on preoperative risk stratification, regional therapeutics and peritonectomy procedures, and quality assurance relating to ovarian cancer surgery. This comprehensive text is essential reading for all practitioners working with patients with ovarian cancers.
Author: Michael Ola Idowu
Publisher: Springer
ISBN: 3319163043
Category : Medical
Languages : en
Pages : 742
Get Book
Book Description
Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.
Author: John Masters
Publisher: Springer Science & Business Media
ISBN: 9401133042
Category : Medical
Languages : en
Pages : 299
Get Book
Book Description
Growing human cancer cells in primary culture requires patience, intuition, care and experience. This is one of the few areas where the wrinkled senior scientist can be more productive than the bright young post-doc. There are few mechanical aids, no automated procedures, and kits are unheard-of. There is no right way to do it and every tumour is different. But this book will make it easier! Chapter 1 on characterization is essential reading. Much published work is useless because of the failure to take two simple steps to characterise the cells. The first step is to fully record all the clinical data - the absence of this information can render the work valueless. The second step is to confirm the origin of the tissue to exclude cross contamination. The wastage of years of work can be avoided with the use of a simple DNA preparation with a couple of commercially-available probes. Chapter 2 describes the development of serum-free media. This is a goal many would like to achieve, particularly if someone else does it, as it is laborious and empirical. Defined serum-free medium is essential for studies of growth factors and has major advantages in the commercial preparation of cell products and other applications.
