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Author: Marc E. Rothenberg
Publisher: CRC Press
ISBN: 9780824702861
Category : Medical
Languages : en
Pages : 592
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Book Description
Supplies more than 2200 references to encourage ongoing research! This one-of-a-kind volume synthesizes the latest breakthroughs in the fields of allergy and chemokines resulting in innovative paradigms and new concepts concerning the origin and treatment of allergic diseases. Considers the biological properties of nearly 60 structurally related chemokines and over a dozen receptors! Fashioned to give an up-to-date overview of molecular structure, gene regulation, biological properties, and signal transduction pathways, Chemokines in Allergic Disease documents the emergence of chemokines as an important super family of chemoattractant cytokines that promote the activation and development of leukocytes illuminates the processes that control leukocyte accumulation links chemokines with cell recruitment and activation in allergic disease explores the benefits of pharmaceutical intervention in the chemokine pathway covers the fundamental biochemistry, molecular biology, and physical structure of chemokines and their receptors describes transcriptional regulation of chemokine expression discusses virally induced gene expression as a main trigger of allergic responses in children analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages elucidates the cellular network involved in the generation of chemokines in allergic diseases highlights pharmaceutical approaches for the development of chemokine structural analogs, receptor antagonists, and inhibitors of signal transduction offers therapeutic strategies for interfering with chemokines in allergic disorders and more! With contributions from 46 internationally respected clinicians, Chemokines in Allergic Disease is an indispensable reference for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.
Author: Marc E. Rothenberg
Publisher: CRC Press
ISBN: 9780824702861
Category : Medical
Languages : en
Pages : 592
Get Book Here
Book Description
Supplies more than 2200 references to encourage ongoing research! This one-of-a-kind volume synthesizes the latest breakthroughs in the fields of allergy and chemokines resulting in innovative paradigms and new concepts concerning the origin and treatment of allergic diseases. Considers the biological properties of nearly 60 structurally related chemokines and over a dozen receptors! Fashioned to give an up-to-date overview of molecular structure, gene regulation, biological properties, and signal transduction pathways, Chemokines in Allergic Disease documents the emergence of chemokines as an important super family of chemoattractant cytokines that promote the activation and development of leukocytes illuminates the processes that control leukocyte accumulation links chemokines with cell recruitment and activation in allergic disease explores the benefits of pharmaceutical intervention in the chemokine pathway covers the fundamental biochemistry, molecular biology, and physical structure of chemokines and their receptors describes transcriptional regulation of chemokine expression discusses virally induced gene expression as a main trigger of allergic responses in children analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages elucidates the cellular network involved in the generation of chemokines in allergic diseases highlights pharmaceutical approaches for the development of chemokine structural analogs, receptor antagonists, and inhibitors of signal transduction offers therapeutic strategies for interfering with chemokines in allergic disorders and more! With contributions from 46 internationally respected clinicians, Chemokines in Allergic Disease is an indispensable reference for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.
Author: Douglas S. Robinson
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805571127
Category : Medical
Languages : en
Pages : 227
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Book Description
This book explores the cellular and molecular mechanisms involved in asthma and allergic diseases, from basic immunology to the treatment of patients. Arising from a special symposium held to celebrate Professor A. Barry Kay's 20th anniversary as Head of the Department of Allergy and Clinical Immunology at the National Heart and Lung Institute, London, the publication presents 18 review articles by an impressive cross section of experts in the field. Topics considered include Th1 and Th2 cells, the regultion of Th2 cytokine transcription, the role of T cells in the immunopathogenesis of asthma, and MHC-restricted IgE-independent T-cell-induced late-phase responses in human subjects. Further chapters focus on eosinophil adhesion and activation, the role of C-C chemokines in the recruitment of eosinophils, and the interactions between eosinophils and fibroblasts. T-cell recruitment and T-cell interactions in cutaneous basophil hypersensitivity and fibrotic lung disease are discussed, as is the molecular pathology of allergic disease. Finally, treatment approaches are considered in chapters on the molecular basis of corticosteroid actions in asthma, immunosuppression in asthma, and immunotherapy of allergic diseases.
Author: Philip M. Murphy
Publisher: Springer Science & Business Media
ISBN: 3662054035
Category : Medical
Languages : en
Pages : 186
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Book Description
The Ernst Schering Workshop on Chemokine Roles in Immunoregulation and Disease, with contributions by leading experts in the field, succinctly summarizes cutting-edge research in immunology, protein chemistry, and disease. This book gives an up-to-date overview of important developments in immunology with a concise, state-of-the-art review of chemokines. It is a time-saving reference for both researchers and students, providing fast and easy access to the latest information in this important area of research.
Author: Kuldeep Neote
Publisher: Springer Science & Business Media
ISBN: 3764374373
Category : Medical
Languages : en
Pages : 171
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Book Description
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Author: Ruby Pawankar
Publisher: Springer Science & Business Media
ISBN: 4431883150
Category : Medical
Languages : en
Pages : 608
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Book Description
When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as “Exosomes, naturally occurring minimal antigen presenting units” and “Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene.” The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic u- ally confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.
Author: K. Izuhara
Publisher: John Wiley & Sons
ISBN: 1444346679
Category : Medical
Languages : en
Pages : 738
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Book Description
Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit. Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate students and clinicians with a basic understanding of allergic diseases in the respiratory tract.
Author: Caroline A. Hébert
Publisher: Springer Science & Business Media
ISBN: 1592597068
Category : Medical
Languages : en
Pages : 337
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Book Description
Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.
Author: Bruce S. Bochner
Publisher: CRC Press
ISBN: 1000148645
Category : Cooking
Languages : en
Pages : 446
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Book Description
This unique resource-the first book of its kind exclusively devoted to the subject-offers timely coverage of the cells, mechanisms, and proteins involved in allergic inflammation, emphasizing the latest advances in local cell recruitment.
Author: L. Gordon Letts
Publisher: Springer Science & Business Media
ISBN: 9783764368258
Category : Medical
Languages : en
Pages : 232
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Book Description
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Author: Kownatzki
Publisher: Springer
ISBN: 3034888430
Category : Medical
Languages : en
Pages : 146
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Book Description
The present volume summarizes the state of information on chemokines focussing on skin diseases. The first three chapters deal with the structure and molecular biology of chemokines and their receptors. The following three review information on the interaction of chemokines with lymphocytes, mast cells and eosinophilic granulocytes. One chapter deals with the expression of chemokines in several inflammatory skin diseases. The final chapter reports on in vitro evidence for a growth-promoting activity of chemokines in skin-derived tumor cells. The volume is of use for the basic scientist interested in practical aspects and for the physician in search for basic mechanisms of skin diseases.
