Chemistry and Biology of Pteridines, 1989 PDF Download
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Author: Hans-Christoph Curtius
Publisher: de Gruyter
ISBN:
Category : Business & Economics
Languages : en
Pages : 1390
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Book Description
No detailed description available for "Zurich, Switzerland, September 3-8, 1989".
Author: Hans-Christoph Curtius
Publisher: de Gruyter
ISBN:
Category : Business & Economics
Languages : en
Pages : 1390
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Book Description
No detailed description available for "Zurich, Switzerland, September 3-8, 1989".
Author: June E. Ayling
Publisher: Springer Science & Business Media
ISBN: 1461529603
Category : Medical
Languages : en
Pages : 806
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Book Description
The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into folate enzymology, tetrahydrobiopterin and molybdopterin biosynthesis and function, enzyme synthesis and regulation, along with novel synthetic strategies for producing compounds that will expedite further study. The many outstanding scientific contributions found in the following chapters, which represent the work presented at the Symposium, are a reflection of the significant advances made since the Ninth International Symposium held in Zurich in 1989. Since the 7th International Symposium in St. Andrews, Scotland, a tradition has evolved of honoring scientists who have made outstanding contributions to pteridine research with a Gowland Hopkins medal and lectureship. Sir Frederick Gowland Hopkins initiated the first investigation of what later proved to be pteridines in his studies of the yellow and white colors of butterflies.
Author: Hans-Christoph Curtius
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110889005
Category : Science
Languages : en
Pages : 1380
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Book Description
No detailed description available for "Zurich, Switzerland, September 3-8, 1989".
Author: János Fischer
Publisher: John Wiley & Sons
ISBN: 3527336850
Category : Medical
Languages : en
Pages : 258
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Book Description
The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Author: Upendra K. Pandit
Publisher: Springer Science & Business Media
ISBN: 1468413546
Category : Science
Languages : en
Pages : 319
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Book Description
In current thinking, Bioorganic Chemistry may be defined as the area of chemistry which lies in the border region between organic chemistry and biology and which describes and analyzes biological phenomena in terms of detailed molecular structures and molecular mechanisms. This molecular-level view of biological processes is not only essential to their fuller understanding but also serves as the platform for the application of the principles of such processes to areas of health care and technology. The objective of the ASI workshop on " Bioorganic Chemistry in Healthcare and Technology", held in the Hengelhoef Congress Centre in Houthalen-Helchteren, Belgium, from September 18-21, 1990, was to bring together most of the international experts in the field to discuss the current developments and new trends in bioorganic chemistry, especially in relation to the selected theme. The book presents nineteen invited plenary and session lectures and eighteen posters. These cover areas of (i) molecular design of therapeutic and agronomical agents based npon mechanistic rationale or drug-receptor interactions, (ii) production of substances of commercial value via combined organic chemical and bio-chemical methodologies, (iii) fundamental studies on the molecular mechanisms of enzymes and (iv) the evolution of conceptually new molecular systems which are programmed to execute specific recognition and/or catalytic functions. An abstracted version of the plenary discussion held at the end of the workshop is also included. We feel confident that the subject matter of this book will be of interest to a broad group of chemists engaged in academic or industrial research.
Author: M. Rami Reddy
Publisher: Springer Science & Business Media
ISBN: 9780306466762
Category : Medical
Languages : en
Pages : 420
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Book Description
Free energy calculations represent the most accurate computational method available for predicting enzyme inhibitor binding affinities. Advances in computer power in the 1990s enabled the practical application of these calculations in rationale drug design. This book represents the first comprehensive review of this growing area of research and covers the basic theory underlying the method, numerous state of the art strategies designed to improve throughput and dozen examples wherein free energy calculations were used to design and evaluate potential drug candidates.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1032
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Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1024
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Franco M. Muggia
Publisher: Springer Science & Business Media
ISBN: 9780792312536
Category : Medical
Languages : en
Pages : 190
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Book Description
The decade of the 1990s will see an increasing emphasis on the modulation of chemotherapeutic drug selectivity and in the 'lock and key' approach to new targets to control malignant proliferation. The contents of this volume appropriately reflect these scientific undercurrents. An emerging powerful tool of molecular pharmacology is described by Holcenberg and Wu. Manipulation of genetic expression by modification of messenger RNA is now within our reach, and the basic concepts are suc cinctly reviewed as a primer on future biochemical engineering of new anti cancer molecules. Another concept that appears to be worthy of further study in both experimental and clinical chemotherapy concerns obs'ervations on the modulation of activity by the nucleoside transport inhibitor, dipyri damole. How potentiation of several anticancer drugs occurs has practical, as well as theoretical, ramifications, discussed by Goel and HowelL Finally, O'Dwyer and La Creta present a fresh look at sensitization of chemotherapy by the hypoxic radiosensitizer, SR-2731.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 180
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Book Description
