Chemical Testing Using New Approach Methodologies (NAMs) PDF Download
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Author: Amy J. Clippinger
Publisher: Frontiers Media SA
ISBN: 2832508596
Category : Science
Languages : en
Pages : 139
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Book Description
Author: Amy J. Clippinger
Publisher: Frontiers Media SA
ISBN: 2832508596
Category : Science
Languages : en
Pages : 139
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Book Description
Author: Wojewodzic, Marcin W.
Publisher: Nordic Council of Ministers
ISBN: 928937313X
Category : Science
Languages : en
Pages : 86
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Book Description
Available online: https://pub.norden.org/temanord2022-526/ New Approach Methodologies (NAMs) are an emerging tool in toxicology for performing chemical risk assessment. NAMs reduce animal testing while increasing robustness, throughput and providing a mechanistic understanding of chemical modes-of-actions, in accordance with the Next Generation Risk Assessment principles. The workshop’s objective was to increase risk assessors’ understanding of the data produced by NAMs and their ability to use it for regulatory actions under REACH and CLP. It aimed to highlight the main challenges for NAMs, discuss possible advancements in using NAMs, and increase knowledge and competence within the relevant Nordic authorities. It also served to facilitate discussions about the obstacles to implementing NAMs in regulatory processes, and to identify strategies (including omics approaches) for increasing their use in read-across and grouping processes.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309151732
Category : Nature
Languages : en
Pages : 217
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Book Description
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Author: Harry Salem
Publisher: CRC Press
ISBN: 0203008790
Category : Medical
Languages : en
Pages : 616
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Book Description
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309264685
Category : Nature
Languages : en
Pages : 210
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Book Description
From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.
Author:
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages : 40
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Book Description
Author: United States. Environmental Protection Agency
Publisher: Agency
ISBN:
Category : Medical
Languages : en
Pages : 112
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Book Description
Author: Mark T. D. Cronin
Publisher: Royal Society of Chemistry
ISBN: 1849730040
Category : Medical
Languages : en
Pages : 689
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Book Description
This book defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals.
Author: K. Clive Thompson
Publisher: John Wiley & Sons
ISBN: 140514470X
Category : Science
Languages : en
Pages : 408
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Book Description
As an integral component of environmental policy, it has become essential to regulate and monitor toxic substances. Past emphasis has been primarily on analytical approaches to the detection of specific, targeted contaminants, thus allowing chemical characterisation. However, toxicity testing or biological assessment is necessary for ecotoxicological evaluation, and this offers marked benefits and advantages that complement chemical analysis. Key issues to be addressed include identification of pertinent tests, reproducibility and robustness of these tests, and cost considerations.This book examines these issues and describes and explains the approaches that have been developed for environmental toxicity evaluations. Advantages, benefits and drawbacks of the strategies and methods are highlighted. Directed equally at ecotoxicologists, industrial chemists, analytical chemists and environmental consultants, this book is written in a way that will prove helpful to both new and experienced practitioners.
Author: Sean Ekins
Publisher: Wiley-Interscience
ISBN: 9780470049624
Category : Science
Languages : en
Pages : 0
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Book Description
A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.
