Changing Connectomes

Changing Connectomes PDF Author: Marcus Kaiser
Publisher: MIT Press
ISBN: 0262044617
Category : Science
Languages : en
Pages : 271

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Book Description
An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages. The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development. Drawing on a range of results from experimental, clinical, and computational studies, Kaiser describes changes during healthy brain maturation and during brain network disorders (including such neurodevelopmental conditions as schizophrenia and depression), brain injury, and neurodegenerative disorders including dementia. He argues that brain stimulation is an area where understanding connectome development could help in assessing long-term effects of interventions. Changing Connectomes is a suitable starting point for researchers who are new to the field of connectomics, and also for researchers who are interested in the link between brain network organization and brain and cognitive development in health and disease. Matlab/Octave code examples available at the MIT Press website will allow computational neuroscience researchers to understand and extend the shown mechanisms of connectome development.

Changing Connectomes

Changing Connectomes PDF Author: Marcus Kaiser
Publisher: MIT Press
ISBN: 0262044617
Category : Science
Languages : en
Pages : 271

Get Book Here

Book Description
An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages. The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development. Drawing on a range of results from experimental, clinical, and computational studies, Kaiser describes changes during healthy brain maturation and during brain network disorders (including such neurodevelopmental conditions as schizophrenia and depression), brain injury, and neurodegenerative disorders including dementia. He argues that brain stimulation is an area where understanding connectome development could help in assessing long-term effects of interventions. Changing Connectomes is a suitable starting point for researchers who are new to the field of connectomics, and also for researchers who are interested in the link between brain network organization and brain and cognitive development in health and disease. Matlab/Octave code examples available at the MIT Press website will allow computational neuroscience researchers to understand and extend the shown mechanisms of connectome development.

Connectome

Connectome PDF Author: Sebastian Seung
Publisher: HMH
ISBN: 0547508174
Category : Science
Languages : en
Pages : 389

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Book Description
“Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post

Changing Connectomes

Changing Connectomes PDF Author: Marcus Kaiser
Publisher: MIT Press
ISBN: 0262360810
Category : Science
Languages : en
Pages : 271

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Book Description
An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages. The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development.

Connectome

Connectome PDF Author: Sebastian Seung
Publisher: Houghton Mifflin Harcourt
ISBN: 0547508182
Category : Psychology
Languages : en
Pages : 389

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Book Description
The audacious effort to map the brain--and along with it mental afflictions, from autism to schizophrenia--by a rising star in neuroscience.

Infection Prevention and Control

Infection Prevention and Control PDF Author: Paul Elliott
Publisher: CRC Press
ISBN: 1315346079
Category : Medical
Languages : en
Pages : 220

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Book Description
This book presents a variety of perceptions of and perspectives on infection prevention and control. In doing this, the chapters will reflect upon challenging and controversial new ways of looking at infection prevention and control aimed at generating both discussion and debate as well as practical solutions. With this in mind, the book will aim not only to challenge the existing status quo but also push the frontiers of knowledge, thinking and practice where infection prevention and control is concerned. This is vital when considered in the light of cross infection rates, the number of healthcare providers who are being identified by the Care Quality Commission as falling below acceptable standards of infection prevention and control and the almost compulsive persistent non-adherent behaviours of those involved in the provision of medicine, health, social care and other disciplines related to caring with regards to the undertaking of safe and appropriate standards of infection prevention and control. There is no doubt that this book will be challenging with regards to the readers' perceptions and perspectives of infection prevention and control. Where this topic is concerned however, such a challenging approach is vital if the health, safety and well being of individuals is to be positively promoted among all those involved in the health and wellbeing of others.

The Pyramid Approach

The Pyramid Approach PDF Author: George Woodrow
Publisher: Rowman & Littlefield
ISBN: 147581352X
Category : Education
Languages : en
Pages : 233

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Book Description
This book explains why virtually all children can achieve proficiency or higher. And it gives educators the tools to help them achieve those levels of learning. The notion that schools are “waiting for Superman” or Wonder Woman to rescue them is at best a fantasy and at worst, damaging to schools and school systems that advance this type of flawed thinking. This is why in this book the reader will be encouraged to embrace the concept that only through building effective teams (collective instructional leadership) will schools begin to realize their stated goal—educate “all” students. It may take a village to raise children but it takes collective instructional leadership to educate them. This book takes great care to ask the questions that policymakers, educators, parents, students and the larger community want answered: Can you handle the truth? Why is team leadership needed? How do campuses improve their team dynamics? What methods do high performing nations use to excel? What strategies really work in high poverty schools? Where do American schools rank on the rigor scale? What is trust and how is it developed? What are campus learning disabilities? How do beliefs about human capacity affect student achievement levels? What methods motivate students to work hard? What do we really mean when we say, “All children can learn”? The Pyramid Approach was designed by Dr. George Woodrow, Jr. for use by educators. The Pyramid is research-based; it aligns theory with professional practice. In addition, it strives to take what we know and provide a practical framework to effectively apply that same knowledge in ways that promotes student achievement. The Pyramid Approach calls attention to the need for a systematic framework that recognizes the interconnectedness among research methods.

Bio-Inspired Information Pathways

Bio-Inspired Information Pathways PDF Author: Martin Ziegler
Publisher: Springer Nature
ISBN: 3031367057
Category :
Languages : en
Pages : 439

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Book Description


From Electrons to Elephants and Elections

From Electrons to Elephants and Elections PDF Author: Shyam Wuppuluri
Publisher: Springer Nature
ISBN: 3030921921
Category : Science
Languages : en
Pages : 886

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Book Description
This highly interdisciplinary book, covering more than six fields, from philosophy and sciences all the way up to the humanities and with contributions from eminent authors, addresses the interplay between content and context, reductionism and holism and their meeting point: the notion of emergence. Much of today’s science is reductionist (bottom-up); in other words, behaviour on one level is explained by reducing it to components on a lower level. Chemistry is reduced to atoms, ecosystems are explained in terms of DNA and proteins, etc. This approach fails quickly since we can’t cannot extrapolate to the properties of atoms solely from Schrödinger's equation, nor figure out protein folding from an amino acid sequence or obtain the phenotype of an organism from its genotype. An alternative approach to this is holism (top-down). Consider an ecosystem or an organism as a whole: seek patterns on the same scale. Model a galaxy not as 400 billion-point masses (stars) but as an object in its own right with its own properties (spiral, elliptic). Or a hurricane as a structured form of moist air and water vapour. Reductionism is largely about content, whereas holistic models are more attuned to context. Reductionism (content) and holism (context) are not opposing philosophies — in fact, they work best in tandem. Join us on a journey to understand the multifaceted dialectic concerning this duo and how they shape the foundations of sciences and humanities, our thoughts and, the very nature of reality itself.

Contemporary Natural Philosophy and Philosophies - Part 1

Contemporary Natural Philosophy and Philosophies - Part 1 PDF Author: Gordana Dodig-Crnkovic
Publisher: MDPI
ISBN: 3038978221
Category : Philosophy
Languages : en
Pages : 350

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Book Description
Modern information communication technology eradicates barriers of geographic distances, making the world globally interdependent, but this spatial globalization has not eliminated cultural fragmentation. The Two Cultures of C.P. Snow (that of science–technology and that of humanities) are drifting apart even faster than before, and they themselves crumble into increasingly specialized domains. Disintegrated knowledge has become subservient to the competition in technological and economic race leading in the direction chosen not by the reason, intellect, and shared value-based judgement, but rather by the whims of autocratic leaders or fashion controlled by marketers for the purposes of political or economic dominance. If we want to restore the authority of our best available knowledge and democratic values in guiding humanity, first we have to reintegrate scattered domains of human knowledge and values and offer an evolving and diverse vision of common reality unified by sound methodology. This collection of articles responds to the call from the journal Philosophies to build a new, networked world of knowledge with domain specialists from different disciplines interacting and connecting with other knowledge-and-values-producing and knowledge-and-values-consuming communities in an inclusive, extended, contemporary natural–philosophic manner. In this process of synthesis, scientific and philosophical investigations enrich each other—with sciences informing philosophies about the best current knowledge of the world, both natural and human-made—while philosophies scrutinize the ontological, epistemological, and methodological foundations of sciences, providing scientists with questions and conceptual analyses. This is all directed at extending and deepening our existing comprehension of the world, including ourselves, both as humans and as societies, and humankind.

Emergence in Context

Emergence in Context PDF Author: Robert C. Bishop
Publisher: Oxford University Press
ISBN: 0192666630
Category : Science
Languages : en
Pages : 360

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Book Description
Science, philosophy of science, and metaphysics have long been concerned with the question of how order, stability, and novelty are possible and how they happen. How can order come out of disorder? This book introduces a new account, contextual emergence, seeking to answer these questions. The authors offer an alternative picture of the world with an alternative account of how novelty and order arise, and how both are possible. Contextual emergence is grounded primarily in the sciences as opposed to logic or metaphysics. It is both an explanatory and ontological account of emergence that gets beyond the impasse between “weak” and “strong” emergence in the emergence debates. It challenges the “foundationalist” or hierarchical picture of reality and emphasizes the ontological and explanatory fundamentality of multiscale stability conditions and their contextual constraints, often operating globally over interconnected, interdependent, and interacting entities and their multiscale relations. It also focuses on the conditions that make the existence, stability, and persistence of emergent systems and their states and observables possible. These conditions and constraints are irreducibly multiscale relations, so it is not surprising that scientific explanation is often multiscale. Such multiscale conditions act as gatekeepers for systems to access modal possibilities (e.g., reducing or enhancing a system's degrees of freedom). Using examples from across the sciences, ranging from physics to biology to neuroscience and beyond, this book demonstrates that there is an empirically well-grounded, viable alternative to ontological reductionism coupled with explanatory anti-reductionism (weak emergence) and ontological disunity coupled with the impossibility of robust scientific explanation (strong emergence). Central metaphysics of science concerns are also addressed. Emergence in Context: A Treatise in Twenty-First Century Natural Philosophy is written primarily for philosophers of science, but also professional scientists from multiple disciplines who are interested in emergence and particularly in the metaphysics of science.