Central and Peripheral Significance of Neuropeptide Y and Its Related Peptides PDF Download
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Author: Janet M. Allen
Publisher:
ISBN:
Category : Baltimore, MD
Languages : en
Pages : 562
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 549
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Book Description
The current meeting sponsored by the New York Academy of Sciences represents the first open meeting on the NPY family of peptides. We attempted to highlight several areas of NPY research, including an in-depth discussion of the structure of the native NPY molecule, which we hope will serve as a guide to aid in the development of analogues to assess the critical feature of the molecule essential for receptor binding and signal transduction. Emphasis was also placed on the molecule mechanisms regulating the expression of the genes encoding the peptides. Since NPY is concentrated in tissues affecting cardiovascular performance, attention was directed to the significance of NPY in regulating cardiac and renal function. Finally, much of our present knowledge of NPY has been derived from studies of NPY in neuronal systems. Presentations on the anatomy and physiology of NPY in higher brain centers are followed by an in- depth-review of the function of NPY in the hypothalamus, concentrating on feeding, reproduction and pituitary function.
Author: William F. Colmers
Publisher: Humana
ISBN: 9781475767254
Category : Medical
Languages : en
Pages : 0
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Book Description
Leading experts critically summarize the state of knowledge concerning the molecular, anatomical, physiological, and behavioral aspects of NPY and its congeners. Each article provides a comprehensive and in-depth survey, an overview of the role of NPY in the discipline covered, a discussion of the likely future direction that the field will take, and an up-to-date bibliography. Chapters include a treatment of the evolution of the PP family of genes, the structure of the NPY gene, and the distribution of NPY on the cardiovascular system, actions of NPY on the electrophysiological properties of nerve cells, and the effects of NPY on feeding and behavior. The chapters are written in an accessible style and serve both as an introduction to the field and as an extensive and detailed treatment of the current state of knowledge.
Author: Lars Grundemar
Publisher: Elsevier
ISBN: 0080537456
Category : Medical
Languages : en
Pages : 242
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Book Description
Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. The hypothalamic role of NPY and its relationship with eating disorders and diabetes The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology Development of peptide and non-peptide receptor antagonists
Author: Marwan Alfalah
Publisher: Springer Science & Business Media
ISBN: 9783540405818
Category : Medical
Languages : en
Pages : 580
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Book Description
with contributions by numerous experts
Author: Zofia Zukowska
Publisher: Springer Science & Business Media
ISBN: 3764374276
Category : Medical
Languages : en
Pages : 264
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Book Description
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
Author: Viktor Mutt
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 392
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Author: Ambikaipakan Balasubramaniam
Publisher: Humana
ISBN: 9781489941527
Category : Medical
Languages : en
Pages : 246
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Book Description
The observation that neuropeptide Y (NPY) is the most abundant peptide present in the mammalian nervous system and the finding that it elicits the most powerful orexigenic signal have led to active investigations of the properties of the NPY family of hormones, including peptide YY (PYY) and pancreatic polypeptide (PP). Nearly two decades of research have led to the identification of several NPY receptor subtypes and the development of useful receptor selective ligands. Moreover, these investigations have imp- cated NPY in the pathophysiology of a number of diseases, including feeding disorders, seizures, memory loss, anxiety, depression, and heart failure. Vigorous efforts are therefore continuing, not only to understand the bioche- cal aspects of NPY actions, but also toward developing NPY-based treatments for a variety of disorders. To facilitate these efforts, it was decided to produce the first handbook on NPY research techniques as part of the Methods in Molecular Biology Series. In compiling Neuropeptide Y Protocols, I have gathered contributions on techniques considered critical for the advancement of the NPY field from experts in various disciplines. Each chapter starts with a brief introduction, with Materials and Methods sections following. The latter sections are presented in an easy to follow step-by-step format. The last section of the chapter, Notes, highlights pitfalls and the maneuvers employed to overcome them. This information, not usually disseminated in standard research pub- cations, may prove extremely useful for investigators employing these te- niques in NYP research.
Author: Lars Grundemar
Publisher:
ISBN:
Category :
Languages : en
Pages : 145
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Book Description
Author: William Colmers
Publisher:
ISBN: 9781475767247
Category :
Languages : en
Pages : 584
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Book Description
Author: Steven L. Parker
Publisher:
ISBN: 9781626184213
Category : Neuropeptide Y
Languages : en
Pages : 0
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Book Description
This book presents a broad summary of current knowledge concerning the structure and biochemistry of neuropeptide Y in relation to its role in feeding and interactions with receptors, transducers, effectors and channels that can also connect to food intake. The very high conservation of NPY sequence indicates its critical importance in basal metabolic regulation. Mutations connecting to NPY are virtually absent, and those affecting the Y1 and Y2 receptors are very few. From the evidence presented across vertebrate classes, NPY appears mainly as metabotropic driver via the Y1 group of receptors, and its negative metabotropicity through the Y2 receptor is only of importance in the mammal, and then tempered by Y2 receptor masking in the hypothalamus and low numbers in the cortex, and by low availability of NPY outside the forebrain. Anatomically, NPY is well-represented especially in limbic areas of the forebrain, but the feeding-critical presence of Y1 receptors is, at least in the rodent, highest in the neocortex, and evidence presented in this book points to much larger involvement of cortical NPY receptors in feeding regulation than is usually perceived. The strong presence of this highly conserved peptide in the vertebrate forebrain is increasingly documented as linked not only to the regulation of glucose metabolism (and insulin activity), but also as directly involved in the operation of transducers, effectors and channels. This should be enabled especially by the high interactivity of the acidic sector of NPY (which is not shared by NPY-related systemic peptides, peptide YY and pancreatic polypeptide), and results in partial agonism and possibly also in accumulation in the bilayer. NPY could be involved as a helper agonist in several parts of the vertebrate metabolome.
