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Author: Bruno M. L. Goddeeris
Publisher: CRC Press
ISBN: 9780849349522
Category : Medical
Languages : en
Pages : 264
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Book Description
Within the last 10 years, the immune system of ruminants, especially T cells and their interactions with other cells, has been an important topic of study for veterinary immunologists and an area of interest for medical and fundamental immunologists. This book brings together all the latest data on ruminant cell-mediated immunology. In the first half of the book, leukocytes and their membrane molecules and cytokines are reviewed. Markers, tissue distribution, functional characterization, ontogeny, cytokines, and histocompatibility are covered in depth in separate chapters. In the second half of the book, cell-mediated immune responses against infectious diseases such as East Coast fever, infectious bovine rhinotracheitis, foot and mouth disease, maedi-visna, and gastrointestinal nematodes are analyzed. The application of cytokines to ruminants against infectious diseases is also reviewed.
Author: Bruno M. L. Goddeeris
Publisher: CRC Press
ISBN: 9780849349522
Category : Medical
Languages : en
Pages : 264
Get Book Here
Book Description
Within the last 10 years, the immune system of ruminants, especially T cells and their interactions with other cells, has been an important topic of study for veterinary immunologists and an area of interest for medical and fundamental immunologists. This book brings together all the latest data on ruminant cell-mediated immunology. In the first half of the book, leukocytes and their membrane molecules and cytokines are reviewed. Markers, tissue distribution, functional characterization, ontogeny, cytokines, and histocompatibility are covered in depth in separate chapters. In the second half of the book, cell-mediated immune responses against infectious diseases such as East Coast fever, infectious bovine rhinotracheitis, foot and mouth disease, maedi-visna, and gastrointestinal nematodes are analyzed. The application of cytokines to ruminants against infectious diseases is also reviewed.
Author: W. Ivan Morrison
Publisher: Cambridge University Press
ISBN: 0521324432
Category : Science
Languages : en
Pages : 602
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Book Description
This volume reviews the immune system of domestic ruminants, with particular emphasis on mechanisms of immunity and resistance to infectious diseases.
Author: Joseph Ntsefo Brewoo
Publisher:
ISBN:
Category :
Languages : en
Pages : 222
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Book Description
Author: Peter J. Quinn
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 396
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Book Description
Author: Carlos Reggiardo
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 258
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Book Description
Author: Holger Heine
Publisher: Springer Science & Business Media
ISBN: 3540739300
Category : Science
Languages : en
Pages : 248
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Book Description
This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.
Author: Charles Andrew Carson
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 282
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Book Description
Author: J. Moreno-López
Publisher:
ISBN:
Category :
Languages : sv
Pages : 38
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Book Description
Author: Emery Waine Field
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 146
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Book Description
Author: Alexandria E. Kesterson
Publisher:
ISBN: 9781321905915
Category : Brucellosis in cattle
Languages : en
Pages : 90
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Book Description
The hypothesis of this study is that RB51 booster vaccinations will provide either increased cell mediated or humoral immunity as compared to a single calf-hood vaccination alone. This research includes four specific aims; 1) that multiple doses of RB51 vaccine will induce a measurable increase in cell-mediated and humoral immunity and that this will correlate with a decreased incidence of infection and abortion at challenge; 2) that multiple doses of RB51 will not induce abortion when an adult booster vaccination is given during pregnancy; 3) that we will be able to correlate cell-mediated immunity data with a predicted outcome at challenge to establish an immune correlate for vaccination; 4) that RB51 titers to multiple doses of vaccine will correlate with previous studies in terms of safety of the vaccine. Cattle have been divided into four treatment groups; three treatment groups (n=7 each) and a control group (n=4). Each treatment group was assigned to be vaccinated with zero, one, two, or three doses of vaccine. All cattle were treated under normal ranching conditions and were vaccinated for diseases following the usual protocols for this region. Cell-mediated immunity has been measured through semi-quantitative PCR, cytokine suspension array, flow cytometry, and cell proliferation and killing assays. Humoral immunity was measured through an RB51 ELISA developed de novo at the Wyoming State Veterinary Laboratory (WSVL). Cell killing assays were used to determine the up-regulation in cytokine expression and cell killing. An immortalized bovine macrophage cell line was obtained from the United States Department of Agriculture facility in Ames, IA to perform cell-mediated immunity assays. Baseline results will be presented for all assays listed above. The results will reflect data from all three RB51 vaccine doses. Conclusions will be presented as the characterization and comparison of all three vaccine associated immune responses. Vaccinated cattle and control cattle were challenged with B. abortus S2308 to determine the efficacy of multiple doses on bacterial burden and incidence of abortion.
