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Author: Bernhard H.J. Juurlink
Publisher: Springer Science & Business Media
ISBN: 1461559499
Category : Medical
Languages : en
Pages : 392
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Book Description
Proceedings of the Fourth International Altschul Symposium held at Saskatoon, Saskatchewan, Canada, June 27-29, 1996
Author: Bernhard H.J. Juurlink
Publisher: Springer Science & Business Media
ISBN: 1461559499
Category : Medical
Languages : en
Pages : 392
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Book Description
Proceedings of the Fourth International Altschul Symposium held at Saskatoon, Saskatchewan, Canada, June 27-29, 1996
Author: Robert A. Lazzarini
Publisher:
ISBN: 0124395104
Category :
Languages : en
Pages :
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Book Description
Author: Kazunori Sango
Publisher: Springer Science & Business Media
ISBN: 4431547649
Category : Medical
Languages : en
Pages : 178
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Book Description
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron–Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students and young clinicians.
Author: Russell E. Martenson
Publisher: Taylor & Francis
ISBN: 135142937X
Category : Medical
Languages : en
Pages : 1006
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Book Description
Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.
Author: Gunnar Jeserich
Publisher: Springer Science & Business Media
ISBN: 3642839681
Category : Medical
Languages : en
Pages : 558
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Book Description
Proceedings of the NATO Advanced Research Workshop on Cellular and Molecular Biology of Myelination, held at Monastery Ohrbeck near Osnabrück, FRG, August 28-September 2 1989
Author: Jarma Palo
Publisher: Springer Science & Business Media
ISBN: 1468425145
Category : Medical
Languages : en
Pages : 632
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Book Description
A satellite symposium entitled "Myelination and Demyelination: Recent Chemical Advances" was held in Helsinki from August 29 to 31, 1977, after the Sixth International Meeting of the International Society for Neurochemistry (ISN) in Copenhagen. Myelin is a nervous tissue structure that is most suitable as a subject of biochemical investigation. It is easy to isolate in a highly purified form, is rather stable even after death, and is af fected by a variety of neurological and other diseases. Its lesions are particularly important in the study of multiple sclerosis, a disease which is relatively prevalent in Finland and has therefore been of interest to a great many Finnish scientists. The first half of this book is concerned with the biochemical composition and molecular organization of myelin, the second half with the experimental and clinical aspects of demyelination. The comments given after each of the presentations at the symposium were not recorded as such, but each author was requested to modify his or her paper accordingly. The editing and publication of this book would not have been possible without the excellent efforts and co-operation of my wife, Mrs. L.-M. Palo, acting as general secretary and later as editorial secretary of the symposium. As Organizing Committee Chairman, I would also like to thank the members of the Committee: Dr. M. Haltia, Dr. E. Kivalo, Dr. T. Kosunen, Dr. M. Panelius, and especially Dr.
Author: Robert A. Lazzarini
Publisher: Academic Press
ISBN: 9780124395121
Category : Demyelination
Languages : en
Pages : 1182
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Book Description
With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. This book brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. It represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
Author: Ian D. Duncan
Publisher: Springer Science & Business Media
ISBN: 1461422183
Category : Medical
Languages : en
Pages : 296
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Book Description
Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.
Author: Patricia Armati
Publisher: Cambridge University Press
ISBN: 1139491717
Category : Medical
Languages : en
Pages :
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Book Description
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
Author: Oswald Steward
Publisher: Springer Science & Business Media
ISBN: 1461235405
Category : Medical
Languages : en
Pages : 266
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Book Description
The field of cellular, molecular, and developmental neuroscience repre sents the interface between the three large, well established fields of neu roscience, cell biology, and molecular biology. In the last 10 to 15 years, this new field has emerged as one of the most rapidly growing and exciting subdisciplines of neuroscience. It is now becoming possible to understand many aspects of nervous system function at the molecular level, and there already are dramatic applications of this information to the treatment of nervous system injury, disease, and genetic disorders. Moreover, there is great optimism that new strategies will emerge soon as a result of the explosion of information. This book was written to introduce students to the major issues, ex perimental strategies, and current knowledge base in cellular, molecular, and developmental neuroscience. The concept for the book arose from a section of an introductory neuroscience course given to first-year medical students at the University of Virginia School of Medicine. The text pre sumes a basic, but not detailed, understanding of nervous system orga nization and function, and a background in biology. It is intended as an appropriate introductory text for first-year medical students or graduate students in neuroscience, neurobiology, psychobiology, or related pro grams;··and for advanced undergraduate students with appropriate back ground in biology and neuroscience. While some of the specific information presented undoubtedly will be outdated rapidly, the "gestalt" of this emerging field of inquiry as presented here should help the beginning stu dent organize new information.
