Author: Robert Hay
Publisher:
ISBN:
Category : Nature
Languages : en
Pages : 144
Book Description
ATCC Quality Control Methods for Cell Lines
Author: Robert Hay
Publisher:
ISBN:
Category : Nature
Languages : en
Pages : 144
Book Description
Publisher:
ISBN:
Category : Nature
Languages : en
Pages : 144
Book Description
Synthesis of Bioactive Scaffolds
Author: Rakesh Kumar Sharma
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110797429
Category : Science
Languages : en
Pages : 414
Book Description
Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110797429
Category : Science
Languages : en
Pages : 414
Book Description
Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.
Recent advances in organocatalytic cascade reactions for enantioselective synthesis of chiral spirolactone skeletons
Author: Jun Yang
Publisher: OAE Publishing Inc.
ISBN:
Category : Science
Languages : en
Pages : 54
Book Description
Chiral spirolactones, including spiropropyllactones, spirobutyrolactones, and spirovalerolactones, are important heterocyclic frameworks that attracted the attention of organic and medicinal chemists because these motifs constitute the core structure of several natural products and bioactive molecules. The absolute configuration and the substituents on the fully substituted spirocyclic stereocenter of the lactone can potentially enhance specificity for ligand-protein binding and enhance bioavailability, potency, and metabolic stability. So, intensive attention from chemists has been paid to the synthetic methods leading to such prominent structural motifs. The synthetic methods can be divided into two main classes. The first approach takes advantage of the presence of the existing lactone structure and focuses on its functionalization. The second approach is the lactone framework constructed from various precursors in a direct spirolactonization reaction. In this review, for convenience in reading, the recent advances in the synthesis of spirolactones are summarized and discussed according to the two major organocatalytic asymmetric synthetic routes: (i) using the lactone-related frameworks as building blocks; and (ii) direct spirolactonization reaction using various reagents. This review also describes both the mechanisms and related transformations, and gives some insights into challenging issues in this research field, which will enlighten the future development of this field.
Publisher: OAE Publishing Inc.
ISBN:
Category : Science
Languages : en
Pages : 54
Book Description
Chiral spirolactones, including spiropropyllactones, spirobutyrolactones, and spirovalerolactones, are important heterocyclic frameworks that attracted the attention of organic and medicinal chemists because these motifs constitute the core structure of several natural products and bioactive molecules. The absolute configuration and the substituents on the fully substituted spirocyclic stereocenter of the lactone can potentially enhance specificity for ligand-protein binding and enhance bioavailability, potency, and metabolic stability. So, intensive attention from chemists has been paid to the synthetic methods leading to such prominent structural motifs. The synthetic methods can be divided into two main classes. The first approach takes advantage of the presence of the existing lactone structure and focuses on its functionalization. The second approach is the lactone framework constructed from various precursors in a direct spirolactonization reaction. In this review, for convenience in reading, the recent advances in the synthesis of spirolactones are summarized and discussed according to the two major organocatalytic asymmetric synthetic routes: (i) using the lactone-related frameworks as building blocks; and (ii) direct spirolactonization reaction using various reagents. This review also describes both the mechanisms and related transformations, and gives some insights into challenging issues in this research field, which will enlighten the future development of this field.
Bone Tissue Engineering
Author: Jeffrey O. Hollinger
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 462
Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 462
Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
The Application of Bioactive Materials in Bone Repair
Author: Hu Yan
Publisher: Frontiers Media SA
ISBN: 2832556736
Category : Technology & Engineering
Languages : en
Pages : 203
Book Description
Biological activity, in the field of materials, mainly refers to the properties that can induce special biological and chemical reactions at the interface between materials and biological tissues, forming chemical bonds between materials and biological tissues. A bioactive material is a biomaterial that is able to participate in a regenerative process at the molecular level and dictate molecular and cellular events in a preferred and predictable way. In the process of biomineralization, the ability of biological material to chemically bond with living bone is an important index of the biomaterial, and the biological activity of the material in vivo is reflected by the simulated body fluid-SBF ability of apatite formed on the surface of the material. In the field of bone repair, bioactive materials such as hydrogels, agglomerates, and magnetic nanoparticles are playing an increasingly important role. Compared with traditional bone repair materials, bioactive materials have many advantages, such as high biocompatibility, simulation of the extracellular environment, and easy engineering modification. In addition, as a delivery system, bioactive materials are modified and engineered to be minimally invasive, targeted, and sustainably released. The above characteristics have important application value in the field of bone repair.
Publisher: Frontiers Media SA
ISBN: 2832556736
Category : Technology & Engineering
Languages : en
Pages : 203
Book Description
Biological activity, in the field of materials, mainly refers to the properties that can induce special biological and chemical reactions at the interface between materials and biological tissues, forming chemical bonds between materials and biological tissues. A bioactive material is a biomaterial that is able to participate in a regenerative process at the molecular level and dictate molecular and cellular events in a preferred and predictable way. In the process of biomineralization, the ability of biological material to chemically bond with living bone is an important index of the biomaterial, and the biological activity of the material in vivo is reflected by the simulated body fluid-SBF ability of apatite formed on the surface of the material. In the field of bone repair, bioactive materials such as hydrogels, agglomerates, and magnetic nanoparticles are playing an increasingly important role. Compared with traditional bone repair materials, bioactive materials have many advantages, such as high biocompatibility, simulation of the extracellular environment, and easy engineering modification. In addition, as a delivery system, bioactive materials are modified and engineered to be minimally invasive, targeted, and sustainably released. The above characteristics have important application value in the field of bone repair.
Biomaterials for Artificial Organs
Author: Michael Lysaght
Publisher: Elsevier
ISBN: 0857090844
Category : Technology & Engineering
Languages : en
Pages : 313
Book Description
The worldwide demand for organ transplants far exceeds available donor organs. Consequently some patients die whilst waiting for a transplant. Synthetic alternatives are therefore imperative to improve the quality of, and in some cases, save people's lives. Advances in biomaterials have generated a range of materials and devices for use either outside the body or through implantation to replace or assist functions which may have been lost through disease or injury. Biomaterials for artificial organs reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs.Part one discusses commodity biomaterials including membranes for oxygenators and plasmafilters, titanium and cobalt chromium alloys for hips and knees, polymeric joint-bearing surfaces for total joint replacements, biomaterials for pacemakers, defibrillators and neurostimulators and mechanical and bioprosthetic heart valves. Part two goes on to investigate advanced and next generation biomaterials including small intestinal submucosa and other decullarized matrix biomaterials for tissue repair, new ceramics and composites for joint replacement surgery, biomaterials for improving the blood and tissue compatibility of total artificial hearts (TAH) and ventricular assist devices (VAD), nanostructured biomaterials for artificial tissues and organs and matrices for tissue engineering and regenerative medicine.With its distinguished editors and international team of contributors Biomaterials for artificial organs is an invaluable resource to researchers, scientists and academics concerned with the advancement of artificial organs. - Reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs - Discusses commodity biomaterials including membranes for oxygenators and cobalt chromium alloys for hips and knees and polymeric joint-bearing surfaces for total joint replacements - Further biomaterials utilised in pacemakers, defibrillators, neurostimulators and mechanical and bioprosthetic heart valve are also explored
Publisher: Elsevier
ISBN: 0857090844
Category : Technology & Engineering
Languages : en
Pages : 313
Book Description
The worldwide demand for organ transplants far exceeds available donor organs. Consequently some patients die whilst waiting for a transplant. Synthetic alternatives are therefore imperative to improve the quality of, and in some cases, save people's lives. Advances in biomaterials have generated a range of materials and devices for use either outside the body or through implantation to replace or assist functions which may have been lost through disease or injury. Biomaterials for artificial organs reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs.Part one discusses commodity biomaterials including membranes for oxygenators and plasmafilters, titanium and cobalt chromium alloys for hips and knees, polymeric joint-bearing surfaces for total joint replacements, biomaterials for pacemakers, defibrillators and neurostimulators and mechanical and bioprosthetic heart valves. Part two goes on to investigate advanced and next generation biomaterials including small intestinal submucosa and other decullarized matrix biomaterials for tissue repair, new ceramics and composites for joint replacement surgery, biomaterials for improving the blood and tissue compatibility of total artificial hearts (TAH) and ventricular assist devices (VAD), nanostructured biomaterials for artificial tissues and organs and matrices for tissue engineering and regenerative medicine.With its distinguished editors and international team of contributors Biomaterials for artificial organs is an invaluable resource to researchers, scientists and academics concerned with the advancement of artificial organs. - Reviews the latest developments in biomaterials and investigates how they can be used to improve the quality and efficiency of artificial organs - Discusses commodity biomaterials including membranes for oxygenators and cobalt chromium alloys for hips and knees and polymeric joint-bearing surfaces for total joint replacements - Further biomaterials utilised in pacemakers, defibrillators, neurostimulators and mechanical and bioprosthetic heart valve are also explored
Diversity-Oriented Synthesis
Author: Andrea Trabocchi
Publisher: John Wiley & Sons
ISBN: 1118618149
Category : Science
Languages : en
Pages : 550
Book Description
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Publisher: John Wiley & Sons
ISBN: 1118618149
Category : Science
Languages : en
Pages : 550
Book Description
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Chemo-Enzymatic Cascade Reactions
Author: Dunming Zhu
Publisher: John Wiley & Sons
ISBN: 3527814272
Category : Science
Languages : en
Pages : 400
Book Description
Chemo-Enzymatic Cascade Reactions A groundbreaking book focusing on chemo-enzymatic cascade transformations Chemo-Enzymatic Cascade Reactions offers a unique book that explores biocatalytic-chemical cascade reactions and their applications in the synthesis of valuable chemicals. Written by a noted expert on the topic, this comprehensive resource includes information on the advantages and disadvantages of traditional chemical and biocatalytic reactions and reviews the three modes of chemo-enzymatic transformations: separate-pot-two-step, one-pot-two-step, and one-pot-one-step. The author examines the most current developments of chemo-enzymatic transformations organized by the three modes and types of enzymes and considers retro-synthesis based on both chemical and biocatalytic transformations and the synthetic applications. This groundbreaking book is the first resource to present in one volume the state-of-art advances of the technology and explore the opportunities and challenges of this burgeoning field. The book also considers the future of cascade reactions and the myriad benefits including higher atom economy and production efficiency, and less resource consumption and waste generation. This important book: Offers the first book dedicated exclusively to chemo-enzymatic cascade transformations Explains the importance and the opportunities and challenges of chemo-enzymatic synthetic technology Includes information on the three modes of chemo-enzymatic transformation Reviews the most recent advances in the field Written for organic chemists, chemists in industry, biochemist, catalytic chemists, Chemo-Enzymatic Cascade Reactions offers an understanding to the importance, current advances, the opportunities and challenges of chemo-enzymatic synthetic technology.
Publisher: John Wiley & Sons
ISBN: 3527814272
Category : Science
Languages : en
Pages : 400
Book Description
Chemo-Enzymatic Cascade Reactions A groundbreaking book focusing on chemo-enzymatic cascade transformations Chemo-Enzymatic Cascade Reactions offers a unique book that explores biocatalytic-chemical cascade reactions and their applications in the synthesis of valuable chemicals. Written by a noted expert on the topic, this comprehensive resource includes information on the advantages and disadvantages of traditional chemical and biocatalytic reactions and reviews the three modes of chemo-enzymatic transformations: separate-pot-two-step, one-pot-two-step, and one-pot-one-step. The author examines the most current developments of chemo-enzymatic transformations organized by the three modes and types of enzymes and considers retro-synthesis based on both chemical and biocatalytic transformations and the synthetic applications. This groundbreaking book is the first resource to present in one volume the state-of-art advances of the technology and explore the opportunities and challenges of this burgeoning field. The book also considers the future of cascade reactions and the myriad benefits including higher atom economy and production efficiency, and less resource consumption and waste generation. This important book: Offers the first book dedicated exclusively to chemo-enzymatic cascade transformations Explains the importance and the opportunities and challenges of chemo-enzymatic synthetic technology Includes information on the three modes of chemo-enzymatic transformation Reviews the most recent advances in the field Written for organic chemists, chemists in industry, biochemist, catalytic chemists, Chemo-Enzymatic Cascade Reactions offers an understanding to the importance, current advances, the opportunities and challenges of chemo-enzymatic synthetic technology.
Cutting-Edge Enabling Technologies for Regenerative Medicine
Author: Heung Jae Chun
Publisher: Springer
ISBN: 9811309507
Category : Medical
Languages : en
Pages : 490
Book Description
This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
Publisher: Springer
ISBN: 9811309507
Category : Medical
Languages : en
Pages : 490
Book Description
This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
Catalytic Cascade Reactions
Author: Peng-Fei Xu
Publisher: John Wiley & Sons
ISBN: 1118016025
Category : Science
Languages : en
Pages : 440
Book Description
Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.
Publisher: John Wiley & Sons
ISBN: 1118016025
Category : Science
Languages : en
Pages : 440
Book Description
Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.