Cardiomyocytes in Health and Disease

Cardiomyocytes in Health and Disease PDF Author: Chandrasekharan C. Kartha
Publisher: Springer Nature
ISBN: 3030855368
Category : Science
Languages : en
Pages : 356

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Book Description
This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

Cardiomyocytes in Health and Disease

Cardiomyocytes in Health and Disease PDF Author: Chandrasekharan C. Kartha
Publisher: Springer Nature
ISBN: 3030855368
Category : Science
Languages : en
Pages : 356

Get Book Here

Book Description
This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

Microdomains in the Cardiovascular System

Microdomains in the Cardiovascular System PDF Author: Viacheslav Nikolaev
Publisher: Springer
ISBN: 3319545795
Category : Medical
Languages : en
Pages : 383

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Book Description
The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.

The Mechanization of the Heart

The Mechanization of the Heart PDF Author: Thomas Fuchs
Publisher: University Rochester Press
ISBN: 9781580460774
Category : Medical
Languages : en
Pages : 286

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Book Description
In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs discusses the similarities and differences of the views of the two seventeenth-century scholars William Harvey and Rene Descartes on the beart and circulationof the blood; Fuch traces the reception of the two views in the medical literature of the time and the influence both views had. In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs begins by comparing the views of William Harvey [1578-1657] and Rene Descartes [1596-1650] on the heart and the circulation of the blood through the body. These two seventeenth-century scholars -- one a British medical doctor, the other a French philosopher and mathemetician -- differed substantially in their beliefs: they both accepted the idea of circulation of the blood, but differed on the action of the heart. Fuchs traces the ways the opposing views were received, revised, rejected, or renewed in succeeding generations by medical writers in various parts of Europe. He then examines Harvey's approach to cardiac and circulatory physiology, mainly through an examination of Harvey's book De motu cordis: he follows with a discussion of the background in Aristotelian philosophy that was the requirement for all studies in medicineand how that affected Harvey's beliefs. Fuchs then turns to Descartes's presentation of Harvey's views and shows how his view, rather than Harvey's, was accepted in Europe at that time. Marjorie Grene brings to the translation herdistinguished background in philosophy and her keen insights into medical philosophy. Thomas Fuchs teaches psychiatry at the Rupert-Karls-Universitat, Heidelberg. MarjorieGrene is Professor Emeritus of Philosophy at the University of California at Davis, and Adjunct Professor and Honorary Distinguished Professor of Philosophy at Virginia Tech University.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease PDF Author: Stefaan Verbruggen
Publisher: Academic Press
ISBN: 0128129530
Category : Medical
Languages : en
Pages : 530

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Book Description
Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. - Provides an essential digest of primary research from many fields and disciplines in one convenient volume - Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives - Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Herbal Medicine

Herbal Medicine PDF Author: Iris F. F. Benzie
Publisher: CRC Press
ISBN: 1439807167
Category : Health & Fitness
Languages : en
Pages : 488

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Book Description
The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef

Pathology of Heart Disease in the Fetus, Infant and Child

Pathology of Heart Disease in the Fetus, Infant and Child PDF Author: Michael T. Ashworth
Publisher: Cambridge University Press
ISBN: 1107116287
Category : Family & Relationships
Languages : en
Pages : 361

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Book Description
Clearly presents the pathology of heart disease from fetus to adolescence, integrating histology and macroscopy with effects of treatment.

Pathophysiology of Heart Disease

Pathophysiology of Heart Disease PDF Author: Leonard S. Lilly
Publisher: Lippincott Williams & Wilkins
ISBN: 1469816687
Category : Medical
Languages : en
Pages : 480

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Book Description
Revised and updated for its Fifth Edition, this best-selling text delivers a concise, easy-to-understand introduction to cardiovascular diseases. It is written by internationally recognized Harvard Medical School faculty and select medical students and specifically designed to meet the needs of medical students during their initial encounters with patients with heart disease. This edition has improved consistency of coverage and level of detail and enhanced illustrations. A companion website on thePoint will include the fully searchable text and audio heart sounds, plus an image bank for faculty.

Calcium Signalling and Disease

Calcium Signalling and Disease PDF Author: Ernesto Carafoli
Publisher: Springer Science & Business Media
ISBN: 1402061919
Category : Medical
Languages : en
Pages : 591

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Book Description
Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Heart Regeneration

Heart Regeneration PDF Author: Felix B. Engel
Publisher: World Scientific
ISBN: 9814299804
Category : Medical
Languages : en
Pages : 393

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Book Description
This title presents the major advances of the last decade in the field of cardiac regeneration.

Myocardial Viability

Myocardial Viability PDF Author: Vasken Dilsizian
Publisher: Wiley-Blackwell
ISBN: 9780879934378
Category : Medical
Languages : en
Pages : 448

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Book Description
Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, one that holds significant clinical and prognostic relevance. Authored by physicians of international renown, the book brings together various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of: basic concepts and mechanisms; vascular biology and cellular physiology; advances in functional imaging; and perfusion, metabolism and cell membrane integrity. New concepts, such as stunning and hibernation, are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New and sophisticated examination techniques are also presented, as well as advances in instrumentation and imaging techniques, which may result in improved use of resources and enhanced efficiency of health care delivery. This monograph will serve as a reference source for those interested in the field of myocardial viability, and hopefully improve understanding between investigators from various disciplines. Clinical cardiologists, physicians, and nurses in the field, as well as radiologists, vascular surgeons, reperfusionists, cellular biologists and physiologists, and students will all find material of interest in this book.