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Author: Barry Greenberg
Publisher: CRC Press
ISBN: 1000611639
Category : Medical
Languages : en
Pages : 615
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Book Description
Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.
Author: Barry Greenberg
Publisher: CRC Press
ISBN: 1000611639
Category : Medical
Languages : en
Pages : 615
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Book Description
Exploring the causes, mechanisms, and pathophysiology of cardiac remodeling, this reference offers detailed descriptions of the various components of the remodeling process, as well as new therapeutic interventions and recent and future prospects for the treatment of cardiac remodeling.
Author: Bodh I. Jugdutt
Publisher: Springer Science & Business Media
ISBN: 1461459303
Category : Medical
Languages : en
Pages : 566
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Book Description
The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
Author: Morris Karmazyn
Publisher: Springer Science & Business Media
ISBN: 9783764352691
Category : Medical
Languages : en
Pages : 538
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Book Description
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
Author: Zhanpeng Huang
Publisher: Frontiers Media SA
ISBN: 2889749355
Category : Medical
Languages : en
Pages : 128
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Book Description
Author: Leonardo Roever
Publisher: Frontiers Media SA
ISBN: 2889453316
Category :
Languages : en
Pages : 119
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Book Description
The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.
Author: Pawan K. Singal
Publisher: Springer Science & Business Media
ISBN: 9781402071775
Category : Medical
Languages : en
Pages : 570
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Book Description
The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.
Author: Monte Willis
Publisher: Academic Press
ISBN: 0124055257
Category : Medical
Languages : en
Pages : 339
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Book Description
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Author: Dennis V. Cokkinos
Publisher: Springer
ISBN: 3319981862
Category : Medical
Languages : en
Pages : 406
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Book Description
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.
Author: E. Gratacós
Publisher: S. Karger AG (Switzerland)
ISBN: 9783318022186
Category : Fetal heart
Languages : en
Pages : 0
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Book Description
Fetal echocardiography was initially used to detect structural anomalies, but has more recently also been proposed to assess fetal cardiac function. Functional echocardiography has been demonstrated to select high-risk populations and has been seen to have an effect on the outcome of several fetal conditions. Because of the small size and high heart rate and the restricted access away from the transducer, cardiovascular parameters should be validated but used with caution in the fetus. This special issue on fetal cardiac function is a collection of review and original articles showing several potential clinical and research applications of functional echocardiography in intrauterine growth restriction, twin-to-twin transfusion syndrome, congenital heart disease and aneuploides. The insights provided show that fetal cardiac function assessment is a promising tool that may soon be incorporated into clinical practice to diagnose, monitor or predict outcome in some fetal conditions. Therefore, this special issue on 'fetal cardiac function' provides valuable reading for clinicians and researchers in fetal medicine and cardiology who are interested in the fetal heart.
Author: Yan Yang
Publisher: Frontiers Media SA
ISBN: 2832531687
Category : Medical
Languages : en
Pages : 227
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Book Description
Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically. Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.
