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Author: Zbigniew Brzozka
Publisher: Springer
ISBN: 3319706853
Category : Technology & Engineering
Languages : en
Pages : 245
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Book Description
This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.
Author: Zbigniew Brzozka
Publisher: Springer
ISBN: 3319706853
Category : Technology & Engineering
Languages : en
Pages : 245
Get Book Here
Book Description
This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.
Author: H.M. Piper
Publisher: Springer Science & Business Media
ISBN: 3642752624
Category : Medical
Languages : en
Pages : 568
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Book Description
In the cardiovascular sciences, an increasing demand for the use of modern methods of cell biology has developed. The use of specific cell culture models of the various tissues involved is essential for most of these novel approaches. This book meets the demand for acomprehensive and easy accessible source for cell cul- ture methods in cardiovascular research as it was not previously available. The basic methods for cultures of cardiomyocytes (embryonic and adult), endothelial cells (micro- and macrovascular), smooth muscle cells and pericytes are described in detail by an international selection of experts. Special chapters discuss the use of growth factors and attachment substrates, techniques for co-cultures, cultures on permeable filter membranes and microcarrier cultures. The methodological descriptions are sufficiently detailed for an immediate application in the laboratory. All chapters also contain a critical evaluation of alternative approaches.
Author:
Publisher: BoD – Books on Demand
ISBN: 1837682917
Category : Science
Languages : en
Pages : 296
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Book Description
Technologies in Cell Culture - A Journey From Basics to Advanced Applications is a comprehensive book that offers a broad overview of the subject, encompassing fundamental concepts, modern techniques, and their diverse applications across various fields. Comprising eleven chapters authored by leading international experts in their respective fields, this book adeptly navigates the complexities of cell culture. It provides valuable insights into bioprocessing, cancer biology, regenerative medicine, and more. The book explores innovative strategies for restoring eyesight in individuals with age-related macular degeneration through retinal pigment epithelium monolayers derived from autologous adipose tissue stem cells. We discover novel approaches for utilizing in vitro techniques to evaluate new medications targeting crucial molecular pathways. A deeper comprehension of the tumor microenvironment can be achieved by conducting coculture studies on cancer cells and adipocytes. The readers will gain insight into organoid intelligence, a culmination of advancements in stem cell technologies, bioengineering, and artificial intelligence. For anyone intrigued by unraveling the mysteries of cellular life, Technologies in Cell Culture - A Journey From Basics to Advanced Applications is an indispensable resource, catering to both novice scientists and seasoned researchers seeking to expand their knowledge. Join us on this journey as we explore the myriad ways in which cell culture technology can impact biomedicine and beyond.
Author: Dominik Egger
Publisher: Frontiers Media SA
ISBN: 288971330X
Category : Science
Languages : en
Pages : 183
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Book Description
Dr. Correa is the founder of Lumos Biomed Consulting and holds shares in Cryovida Stem Cell Bank (Mexico). Dr O’Brien holds patents related to regeneration technology and was a co-founder of SurgaColl Technologies. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Author: Jianyi Zhang
Publisher: Springer Nature
ISBN: 3030861406
Category : Technology & Engineering
Languages : en
Pages : 407
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Book Description
This book presents a systematic overview of the technologies currently being explored and utilized in the fields of cardiovascular tissue engineering and regenerative medicine. Considering the unprecedented rapid progress occurring on multiple technological fronts in cardiac tissue engineering, this important new volume fills a need for an up-to-date, comprehensive text on emerging advanced biological and engineering tools. The book is an important resource for anyone looking to understand the emerging topics that have the potential to substantially influence the future of the field. Coverage includes iPS stem cell technologies, nanotechnologies and nanomedicine, advanced biomanufacturing, 3D culture systems, 3D organoid systems, genetic approaches to cardiovascular tissue engineering, and organ on a chip. This book will be a valuable guide for research scientists, students, and clinical researchers in the fields of cardiovascular biology, medicine, and bioengineering, as well as industry-based practitioners working in biomaterial science, nanomaterials and technology, and rapid prototyping and biomanufacturing (3D bioprinting).
Author: Sadettin Ozturk
Publisher: CRC Press
ISBN: 0849351065
Category : Medical
Languages : en
Pages : 788
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Book Description
Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel
Author: Mai-Dung Thi Nguyen
Publisher:
ISBN:
Category : Cardiology
Languages : en
Pages : 180
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Book Description
Cardiovascular disease (CVD) is the leading cause of death in the United States and accounts for nearly 1,372,000 deaths each year. In addition, ~81 million Americans suffer from some form of CVD. Understanding the molecular basis of various manifestations of CVD requires cellular-level studies. However, current technologies for cell culture, fail to recreate the in-vivo environment where cells are subject to pressure and stretch as a consequence of normal hemodynamic loading and unloading. Therefore, to study cardiac cells with physiological relevance, the mechanical loading environment needs to be accurately replicated in-vitro. In order to create an appropriate platform for cardiac cell culture, a micro fluidic cardiac cell culture model ( CCCM) was designed and fabricated. This system consists of a pump, cell culture chamber, pneumatically actuated collapsible valve and a tunable resistance element in series. By varying the pump flow rate, valve closure frequency and the outflow resistance, various conditions associated with normal and dysfunctional heart function were recreated. A rat left ventricle heart muscle cell line (H9c2) was used to establish proof-of-concept and demonstrate the ability of the CCCM to sustain cell culture under normal physiological conditions. Microscopic evaluation of these cells using phase contrast and immunofluoresence demonstrated that cells cultured within the CCCM achieved an in-vivo like phenotype in comparison to static unloaded controls.
Author: Hannah Landecker
Publisher: Harvard University Press
ISBN: 0674265270
Category : Science
Languages : en
Pages : 302
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Book Description
How did cells make the journey, one we take so much for granted, from their origin in living bodies to something that can be grown and manipulated on artificial media in the laboratory, a substantial biomass living outside a human body, plant, or animal? This is the question at the heart of Hannah Landecker's book. She shows how cell culture changed the way we think about such central questions of the human condition as individuality, hybridity, and even immortality and asks what it means that we can remove cells from the spatial and temporal constraints of the body and "harness them to human intention." Rather than focus on single discrete biotechnologies and their stories--embryonic stem cells, transgenic animals--Landecker documents and explores the wider genre of technique behind artificial forms of cellular life. She traces the lab culture common to all those stories, asking where it came from and what it means to our understanding of life, technology, and the increasingly blurry boundary between them. The technical culture of cells has transformed the meaning of the term "biological," as life becomes disembodied, distributed widely in space and time. Once we have a more specific grasp on how altering biology changes what it is to be biological, Landecker argues, we may be more prepared to answer the social questions that biotechnology is raising.
Author: Nabil Dib
Publisher: Springer Science & Business Media
ISBN: 038730939X
Category : Technology & Engineering
Languages : en
Pages : 332
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Book Description
In excess of 7 million people worldwide die of coronary heart disease each year. Only one-third of these heart attack victims recover completely. The remainder suffer the consequences of myocardial infarction and its ill fated remodeling process, resulting in chronic congestive heart failure. This malady alone is the leading cause of hospital admissions in the United States. New breakthroughs in stem cell therapy and tissue engineering have promised to reverse this dismal outcome by cardiovascular repair. World authorities, including scientists and regulatory authorities, have joined in a collaborative effort to present for the reader the first collective review of stem cell therapy for the treatment of cardiovascular disease. These contributions in basic science, pre-clinical and clinical experience guided by the regulatory pathways, assure a rapid course of translational research and clinical trials. The contents of this publication will become a prerequisite for those preparing to meet the challenges of this exciting and potentially rewarding field of stem cell research.
Author: Smadar Cohen
Publisher: Springer Nature
ISBN: 3031025849
Category : Science
Languages : en
Pages : 190
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Book Description
Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration
