Carcinogenic and Mutagenic Metal Compounds 3 PDF Download
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Author: Ernest Merian
Publisher: CRC Press
ISBN: 9782881247811
Category : Medical
Languages : en
Pages : 670
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Book Description
Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Ernest Merian
Publisher: CRC Press
ISBN: 9782881247811
Category : Medical
Languages : en
Pages : 670
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Book Description
Selected papers from the Third Hans Wolfgang Nurnberg Memorial Workshop on Toxic Metal Compounds, Follinica, Italy, April 1988. The workshop discussed the gaps between chemistry and biology, and the topics covered include: the analytical chemistry and speciation of air particulates, water, sediments, soils, and of food and tissue; uptake by plants, mosses, and lichens, including biomonitoring techniques; and the uptake and biological effects of chromium, nickel, cadmium, and aluminum compounds. the papers were first published in issues of Toxicological and environmental chemistry and International journal of environmental analytical chemistry. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Andrew Teasdale
Publisher: John Wiley & Sons
ISBN: 1119551218
Category : Medical
Languages : en
Pages : 548
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Book Description
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Author:
Publisher:
ISBN:
Category : Carcinogenicity testing
Languages : en
Pages : 372
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Book Description
Author: Alan B. G. Lansdown
Publisher: Royal Society of Chemistry
ISBN: 1849737193
Category : Science
Languages : en
Pages : 449
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Book Description
This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.
Author: Alan B. G. Lansdown
Publisher: Royal Society of Chemistry
ISBN: 1849737185
Category : Medical
Languages : en
Pages : 450
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Book Description
This important text comprehensively examines each of the elements for which carcinogenicity has been established, providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1752
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Book Description
Author: Lawrence Fishbein
Publisher:
ISBN:
Category : Carcinogenesis
Languages : en
Pages : 360
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Book Description
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1576
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Book Description
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1352
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Book Description
