Author: Ludmilla A. Morozova-Roche
Publisher: Nova Science Publishers
ISBN: 9781620817551
Category : Calcium-binding proteins
Languages : en
Pages : 0
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Book Description
In this book, the authors describe an important class of calcium binding lysozymes that are evolutionarily related to the lysozyme superfamily and the lactalbumins. The authors take the reader through a journey from the evolution, then the structure and properties of the calcium binding lysozymes. They discuss new unique protein folding pathways with local co-operative, close related folding modes that exhibit multiple folding pathways which are not properties of the lactalbumins or non calcium binding lysozymes. They comprise one of the most diverse group of examples in protein folding. In addition this protein class, especially equine lysozyme, shows peculiar amyloid assembly properties that are not common with other fibril forming proteins. It is one of the first shown to form ring shaped amyloids and other complexes in vitro. Lastly equine lysozyme forms complex with oleic acid, a unique form ELOA, which contributes to the family of the human and bovine lactalbumin analogues HAMLET and BAMLET.
Author: Hans J. Vogel
Publisher: Springer Science & Business Media
ISBN: 1592591833
Category : Science
Languages : en
Pages : 346
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Book Description
Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium channels), fall outside of the scope of these two volumes. Also, calcium-bi- ing proteins involved in bone deposition will not be discussed, as this specific topic has been addressed previously. The focus of these two books is on studies of the calcium-binding proteins and their behavior in vitro and in vivo. The primary emphasis is on protein chemistry and biophysical methods. Many of the methods described will also be applicable to proteins that do not bind calcium. Calcium-Binding Protein Protocols is divided into three main sections. The section entitled Introduction and Reviews provides information on the role of calcium in intracellular secondary messenger activation mechanisms. Mo- over, unique aspects of calcium chemistry and the utilization of calcium in dairy proteins, as well as calcium-binding proteins involved in blood clotting, are addressed.
Author: Evgeniĭ Anatolʹevich Permi︠a︡kov
Publisher:
ISBN: 9781620818657
Category : Calcium-binding proteins
Languages : en
Pages : 187
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Book Description
Author: Eugene Permyakov
Publisher: John Wiley & Sons
ISBN: 1118099540
Category : Science
Languages : en
Pages : 456
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Book Description
Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.
Author: Robert H. Kretsinger
Publisher: Springer
ISBN: 9781461415329
Category : Science
Languages : en
Pages : 0
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Book Description
In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Author: Vladimir N. Uversky
Publisher: Springer Science & Business Media
ISBN: 0387365346
Category : Medical
Languages : en
Pages : 538
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Book Description
The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
Author: Evgeniĭ Anatolʹevich Permi͡akov
Publisher: Nova Publishers
ISBN: 9781594541070
Category : Science
Languages : en
Pages : 150
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Book Description
Small acidic protein a-lactalbumin, one of the major protein components of milk, is one of the most extensively investigated Ca2+-binding proteins, which does not belong to the EF-hand family of calcium-binding proteins. It serves as a model for studies of the mechanisms of protein stability, folding and unfolding. a-Lactalbumin acts as a regulatory subunit of galactosyltransferase in lactose synthase, which catalyses the synthesis of lactose from UDP-galactose and glucose. It represents a classical example of molten globule state at acidic pH and in its apo-form at elevated temperatures. Three-dimensional structures of several ?-lactalbumins are determined. The protein possesses a single strong Ca2+-binding site, which binds Mg2+, Mn2+, Na+, and K+ as well, and several distinct Zn2+-binding sites. The binding of cations to the Ca2+-site increases protein stability against action of heat, various denaturing agents and proteases, while the binding of Zn2+ to the Ca2+-saturated protein decreases its stability and causes its aggregation. ?-Lactalbumin interacts with membranes, proteins, peptides and low molecular weight substrates and products. These interactions are modulated by the binding of metal cations to a-lactalbumin. a-Lactalbumin forms amyloid fibrils at low pH values and some folding variants of a-lactalbumin demonstrate bactericidal activity and some of them cause apoptosis of tumour cells. Thus, ?-lactalbumin is a metal binding protein, the function of which depends on its environment: it takes part in lactose synthesis in the mammary gland and could be important for lowering the incidence of cancer and various infections in breast-fed children.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Md. Shahidul Islam
Publisher: Springer Nature
ISBN: 3030124576
Category : Medical
Languages : en
Pages : 1103
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Book Description
This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Pierre Jollès
Publisher: Birkhauser
ISBN:
Category : Medical
Languages : en
Pages : 476
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Book Description
