Calcitonin Gene-related Peptide and Tachykinins in Relation to Local Sensory Control of Cardiac Contractility and Coronary Vascular Tone PDF Download
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Author: Anders Franco-Cereceda
Publisher:
ISBN:
Category : Blood-vessels
Languages : en
Pages : 74
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Author: Anders Franco-Cereceda
Publisher:
ISBN:
Category : Blood-vessels
Languages : en
Pages : 74
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Book Description
Author: Susan D. Brain
Publisher: Frontiers Media SA
ISBN: 2889767833
Category : Science
Languages : en
Pages : 154
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1332
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Book Description
Author: Rolf Uddman
Publisher: Academic Press
ISBN: 0323148077
Category : Medical
Languages : en
Pages : 498
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Book Description
Vascular Innervation and Receptor Mechanisms: New Perspectives reviews the areas of structure, function, and pathophysiology of the circulatory system. The text focuses on the role of neuropeptides and structural function of endothelium. The book begins with a brief discussion on the background of autonomic and sensory nerves in the circulatory system, which is provided in Chapter 1. Having established the basic studies in the circulatory system, the book moves to the discussion on the analysis of peptidergic innervations and peptides in vascular control in various disorders. The last part of the book features the clinical applications of neuropeptides, perivascular peptides, and vasoactive peptides in different diseases and regulation, such as cardiovascular regulation, hypertension, congestive heart failure, and migraine and cluster headache. The text will be a good reference to both students and professionals in the fields of biology, chemistry, and medicine.
Author: J. Andrew Armour
Publisher: Oxford University Press
ISBN: 9780199775194
Category : Medical
Languages : en
Pages : 492
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Book Description
The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodeling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why some patients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes the synergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional cardiac behavior. On this basic science foundation, subsequent clinical chapters explore the remodeling that occurs in this system with aging, with the evolution of specific cardiac pathologies, and with the psychological concomitants of heart disease. Most importantly, these chapters provide unique insights into how specific therapies like beta-andrenergic receptor blockade not only affect cardiomyocytes directly but also mitigate the adverse neurohumoral changes that accompany disease processes, such as heart failure and essential hypertension. The paradigm advanced in this volume is that heart disease is a multifaceted phenomenon involving the interplay of neurohumoral, cardiomyocyte and structural elements, each of which depends on the other. With our cumulative understanding of these interdependent processes, new avenues for time-appropriate, targeted methods of treating heart diseases can be developed.
Author: William S. Spielman
Publisher: Springer Science & Business Media
ISBN: 1461423643
Category : Medical
Languages : en
Pages : 126
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Book Description
Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years.
Author:
Publisher: Newnes
ISBN: 0080932622
Category : Medical
Languages : en
Pages : 371
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Book Description
Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. - Neurogenic inflammation in historical perspective - Cardiac protection by nociceptive afferents - Molecular mechanisms of nociception - Sensory mechanisms in migraine pathophysiology - Vagal signaling of visceral inflammation - Neurogenic mechanisms in arthritis - Therapeutic implications of vanilloid-type compounds
Author:
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 1120
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Author: J. Andrew Armour
Publisher: Oxford University Press, USA
ISBN:
Category : Law
Languages : en
Pages : 464
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Book Description
New ideas about intrinsic and extrinsic cardiac intrathoracic neurons, the role of spinal cord and medullary and higher center neurons are presented. The final chapters focus on the role that autonomic neurons play in the maintenance of cardiac function in the conscious state as well as in two major clinical conditions, dysrythimias and heart failure.
Author: Council for Tobacco Research--U.S.A.
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 220
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Book Description
