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Author: Alexander Pfeifer
Publisher: Springer
ISBN: 303010513X
Category : Science
Languages : en
Pages : 424
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Book Description
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Author: Alexander Pfeifer
Publisher: Springer
ISBN: 303010513X
Category : Science
Languages : en
Pages : 424
Get Book Here
Book Description
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Author: Olov Lindberg
Publisher: Elsevier Publishing Company
ISBN:
Category : Nature
Languages : en
Pages : 360
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Book Description
Author: Saverio Cinti
Publisher:
ISBN: 9788885030329
Category : Medical
Languages : en
Pages : 94
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Book Description
Author: Bruce Spiegelman
Publisher: Springer
ISBN: 3319727907
Category : Science
Languages : en
Pages : 108
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Book Description
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Author: Douglas Burrin, PhD
Publisher: Elsevier Health Sciences
ISBN: 0444510133
Category : Medical
Languages : en
Pages : 498
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Book Description
The book is intended to provide in-depth reviews of the recent advances in major areas of metabolism in growing domestic animals. The study of metabolism represents a nexus of biological phenomenon that integrates the impact of nutrition, physiology, endocrinology, immunology, biochemistry, and cell biology in an organism. The development of new methodological techniques and experimental approaches have provide scientists with a greater understanding of how key nutrients or substrates are metabolized at the cellular, organ, and whole animal level. This book presents contributions from leading scientists in nutrition and physiology that highlight important new developments in interorgan and tissue-specific metabolism of protein and amino acids, lipids and fatty acids, and carbohydrates in monogastric and runinant species. Authors will describe the impact of specific biochemical pathways and expression of critical enzymes, routes of nutrient or substrate input, and anatomical or structural influences on the rates of metabolism in a given tissue or cell type. Major substrates/ fuels for oxidative metabolism, key signaling pathways, and intracellular molecules that regulate the major metabolic processes will be described. Also included is how the metabolism of growing animals is influenced by ontogeny, stage of differentiation, and major changes in diet, or the environment. The concepts and specific findings in each area are discussed in the context of their impact on the nutrient requirements, growth, environmental impact, healt and well-being of animals. The book will be a useful reference for research scientists, teachers and students interested in and advanced understanding of metabolism in growing animals. The book is written by leading experts and highlights some of the most recent advances in the field of metabolism. It is a useful reference for researchers and advanced level graduate students in nutrition, physiology and animal science. Presents recent advances in the field of metabolism.
Author: Rita De Matteis
Publisher: Frontiers Media SA
ISBN: 2889636577
Category :
Languages : en
Pages : 212
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Book Description
Author: Susanne Klaus
Publisher: CRC Press
ISBN: 1498712649
Category : Science
Languages : en
Pages : 221
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Book Description
Today we know that white and brown adipocytes share many metabolic and molecular pathways, although their physiological function, i.e., energy storage and energy dissipation, respectively, are quite opposite for WAT (white adipose tissue) and BAT (brown adipose tissue). The authors in this book provide a comprehensive volume covering the whole rang
Author: Shamim I. Ahmad
Publisher: Springer
ISBN: 3319198211
Category : Medical
Languages : en
Pages : 375
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Book Description
This book brings a comprehensive treatise about obesity, examining the measures that can be taken to stop and even reduce obesity if these right measures are taken in time. Recent studies show that obesity is on the increase at an alarming rate, especially in the industrialized and affluent countries. A number of reasons have been put forward for this increase, including life style choices, over-eating, over-use of commercially processed food, addiction for fast food, high caloric diet specially containing high levels of sugar and fat, lack of exercise and sedentary life style. Also genetic make up has been associated with obesity. Obesity can lead to a variety of lethal diseases, notably coronary heart disease, cancer and diabetes. These diseases account for the highest number of human death amongst all other causes. There are also a number of other side effects associated with obesity including increased stress, loss of intelligentsia, pancreatitis, premature birth and osteoarthritis. In recent years media have been playing important roles in highlighting the lethality and damage caused by obesity, nevertheless no significant effects can be seen in the population and obesity remains on the increase, especially amongst children. The editors believe that it is important that more education, campaign and research are used to stop this increasing disease.
Author: Patrick Seale
Publisher: Frontiers E-books
ISBN: 2889191346
Category :
Languages : en
Pages : 135
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Book Description
Brown adipose tissue (BAT) has long been recognized as a key thermogenic tissue in eutherian mammals. Brown fat cells contain large numbers of highly specialized mitochondria that oxidize fat and carbohydrate to produce heat. This metabolic inefficiency is due to the presence of Ucp1 in the inner mitochondrial membrane of brown fat cells which dissociates the electrochemical gradient from ATP production. BAT presumably evolved to protect animals against hypothermia in response to cold exposure. However, energy expended by BAT has the added benefit of counteracting obesity and associated metabolic disease, at least in rodents. A very large number of studies have consistently shown that mice carrying increased amounts of active brown fat are lean and healthy. Until recently, it was generally believed that the amount of brown fat tissue was negligible in healthy adult humans. However, PET imaging studies have refuted this notion, and revealed the existence of active BAT in most, if not all, adult humans. Notably, there is a very strong inverse correlation between the amount of activated BAT and fatness in humans. Moreover, activated brown fat is lost with ageing, which also correlates with tendency to gain weight. The field must now address whether variation in brown fat activity is a cause or consequence of weight gain. Brown fat cells are localized in discrete depots of BAT and are also found as clusters interspersed in white fat tissues. The prevalence and function of these so-called “brite” (brown in white) cells in humans remains unknown. The development of strategies to increase the amount and/or activity of brown fat may hold exciting prospects for the treatment of obesity and its associated health consequences. In this Research Topics issue, we would propose to examine the following areas related to brown fat biology: 1. Development of brown and “brite” cells (including: historical/evolutionary perspective, transcriptional pathways, developmental origins) 2. Pathways that influence brown fat cell development (BMP7, TZDs, Prostaglandins, FGF21) 3. Activation of brown fat - focus on sympathetic and sensory innervation (signaling by beta-adrenergic receptors, nerve-fat connections 4. Brown fat thermogenesis in response to cold, diet and hibernation 5. Brown fat in humans including: human brown fat precursors, methods for imaging, factors that influence prevalence, relationship between body mass/obesity and amount of brown fat. 6. Brown fat mitochondria including mechanism of uncoupling (Ucp1 history/structure/function, mitochondrial biogenesis.
Author: David A. Guertin
Publisher: Springer Nature
ISBN: 1071620878
Category : Science
Languages : en
Pages : 319
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Book Description
This detailed volume explores techniques for researching brown adipose tissue (BAT) and the fascinating biology and therapeutic potential of thermogenic adipocytes. The content reflects the advancing technologies in genetics, imaging, and 'omics strategies that are allowing researchers to probe BAT biology at unprecedented depths and detail, yet it also presents classic physiology principles, which remain the core tenets of BAT biology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Brown Adipose Tissue: Methods and Protocols provides perspectives and detailed protocols for the benefit of both new BAT researchers looking for guidance as well as seasoned researchers who would like to expand their toolkits. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
