The Blood Brain Barrier (BBB) PDF Download
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Author: Gert Fricker
Publisher: Springer
ISBN: 3662437872
Category : Science
Languages : en
Pages : 169
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Book Description
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author: Gert Fricker
Publisher: Springer
ISBN: 3662437872
Category : Science
Languages : en
Pages : 169
Get Book Here
Book Description
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author: Dr. Linda Karges-Bone
Publisher: Lorenz Educational Press
ISBN: 1429115017
Category : Education
Languages : en
Pages : 132
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Book Description
The activities in this book provide numerous ways to introduce sensory and gender-based teaching methods into your classroom. Experience minds-on learning with fresh and fascinating tips and techniques for using color, scent, taste, sound and touch to stimulate the minds of your students. Also find practical and easily-implemented classroom applications that utilize the differences between the ways boys and girls acquire and apply knowledge. Begin doing brain surgery from the inside out by Breaking Brain Barriers!
Author: J. Stewart Black
Publisher: Pearson Education
ISBN: 0132703939
Category : Business & Economics
Languages : en
Pages : 228
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Book Description
Of organizations that seek strategic change, 70% fail. In Leading Strategic Change,now in paperback, leading consultants J. Stewart Black and Hal B. Gregersen examine the core problem: organizations fail to change because individuals fail to change. Black and Gregersen identify the "brain barriers" that keep strategic change from success--failure to see, failure to move, and failure to finish--and offer a start-to-finish strategy for helping others change how they view their goals and the steps they must take to achieve them. This book systematically shows you how to implement the single change that makes all the others possible: redirecting individuals' ideas and expectations to be aligned with the new direction of the company.
Author: Anthony J. Suckling
Publisher: Ellis Horwood
ISBN:
Category : Medical
Languages : en
Pages : 216
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Book Description
Author: A.G. de Boer
Publisher: CRC Press
ISBN: 9789057020322
Category : Medical
Languages : en
Pages : 240
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Book Description
The availability of various in vitro and in vivo techniques has considerably advanced the research on drug transport and metabolism across the blood-brain barrier (BBB). These specialized and sophisticated experimental strategies are of fundamental importance if one is to gain a greater understanding of enhanced and selective drug delivery to the brain. The reader will find in this book methods for in vitro endothelial/astrocyte cell culture models, and for in vivo intracerebral microdialysis to study drug tranport across the BBB. This book, however, is not merely a laboratory manual consisting of recipes for BBB research; it permits the presentation of the different methods in fine detail, revealing tricks and short cuts that frequently do not appear in the literature. The researcher is well aware that differences (subtle or otherwise) in experimental steps used in different laboratories may influence the outcome of any particular procedure. The book also illustrates the accessibility and the application of the different methods in different species. Background information of the protocol is given in every chapter, which also contains a literature list that the reader may wish to refer to for further information. This volume will be invaluable to basic researchers as well as to those involved in the search for agents suitable for pharmaceutic intervention in the central nervous system.
Author: Aaron B. Rochlen
Publisher: Routledge
ISBN: 1136291636
Category : Psychology
Languages : en
Pages : 212
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Book Description
Breaking Barriers in Counseling Men is a unique collection of personal and engaging contributions from nationally recognized scholars and clinicians with expertise in treating men. The editors have selected men’s clinicians who address areas as diverse as sexual dysfunction, male bonding over sports, father-son relationships, and counseling men in the military. Featuring a mix of clinical tips, personal anecdotes, and theoretical reframing, this book takes clinicians invested in these issues to the next level, breaking down barriers to connecting with men and getting them the help that is so often needed.
Author: Susan Masino
Publisher: Oxford University Press
ISBN: 0190497998
Category : Cooking
Languages : en
Pages : 425
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Book Description
Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer's disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.
Author: Yasemin Gürsoy Özdemir
Publisher: Academic Press
ISBN: 0128038004
Category : Medical
Languages : en
Pages : 380
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Book Description
Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer's, Parkinson's and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. - Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases - Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier - Written in a language that makes it easy to understand nanotechnology drug delivery techniques - Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors
Author: Ricardo Esparza-LeBlanc
Publisher: Solution Tree Press
ISBN: 1935543164
Category : Education
Languages : en
Pages : 260
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Book Description
Strong leadership, parent involvement, mentoring, data-based intervention, and high expectations are known factors in student success, but what do they really look like in practice—and are they as powerful as research says? This book illustrates the specific strategies and critical steps that transformed a school beset with poverty and shockingly low proficiency into a National Showcase School.
Author: Barbara Oakley, PhD
Publisher: Penguin
ISBN: 1101982853
Category : Business & Economics
Languages : en
Pages : 306
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Book Description
Mindshift reveals how we can overcome stereotypes and preconceived ideas about what is possible for us to learn and become. At a time when we are constantly being asked to retrain and reinvent ourselves to adapt to new technologies and changing industries, this book shows us how we can uncover and develop talents we didn’t realize we had—no matter what our age or background. We’re often told to “follow our passions.” But in Mindshift, Dr. Barbara Oakley shows us how we can broaden our passions. Drawing on the latest neuroscientific insights, Dr. Oakley shepherds us past simplistic ideas of “aptitude” and “ability,” which provide only a snapshot of who we are now—with little consideration about how we can change. Even seemingly “bad” traits, such as a poor memory, come with hidden advantages—like increased creativity. Profiling people from around the world who have overcome learning limitations of all kinds, Dr. Oakley shows us how we can turn perceived weaknesses, such as impostor syndrome and advancing age, into strengths. People may feel like they’re at a disadvantage if they pursue a new field later in life; yet those who change careers can be fertile cross-pollinators: They bring valuable insights from one discipline to another. Dr. Oakley teaches us strategies for learning that are backed by neuroscience so that we can realize the joy and benefits of a learning lifestyle. Mindshift takes us deep inside the world of how people change and grow. Our biggest stumbling blocks can be our own preconceptions, but with the right mental insights, we can tap into hidden potential and create new opportunities.
