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Author: J.C Baron
Publisher: Springer Science & Business Media
ISBN: 9401135282
Category : Medical
Languages : en
Pages : 206
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Book Description
Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.
Author: J.C Baron
Publisher: Springer Science & Business Media
ISBN: 9401135282
Category : Medical
Languages : en
Pages : 206
Get Book Here
Book Description
Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.
Author: European Economic Community
Publisher: Springer Science & Business Media
ISBN:
Category : Medical
Languages : en
Pages : 220
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Book Description
.the book is most valuable for those who are starting to study the brain dopaminergic system and are considering PET as a tool.' Nuclear Medicine 19:9 1992
Author: Richard E. Carson
Publisher: Elsevier
ISBN: 0080540112
Category : Science
Languages : en
Pages : 535
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Book Description
This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. - Authored by international authorities in PET - Provides the latest up-to-date techniques and applications - Covers all fundamental disciplines of PET in one volume - A comprehensive resource for students, clinicians, and new PET researchers
Author: Philip Seeman
Publisher: Elsevier
ISBN: 012418684X
Category : Science
Languages : en
Pages : 534
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Book Description
Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
Author: Cameron S. Carter
Publisher: Springer Science & Business Media
ISBN: 3642287115
Category : Medical
Languages : en
Pages : 395
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Book Description
This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer’s disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.
Author: Albert Gjedde
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 452
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Book Description
Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain. Key Features * Provides the latest techniques and applications of positron emission tomography (PET) * Covers all fundamental disciplines of PET in one volume * Serves as a comprehensive resource for students, clinicians and new researchers
Author: Rudi A.J.O. Dierckx
Publisher: Springer Nature
ISBN: 3030531767
Category : Medical
Languages : en
Pages : 1127
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Book Description
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
Author: Paul Cumming
Publisher: Cambridge University Press
ISBN: 0521790026
Category : Medical
Languages : en
Pages : 377
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Book Description
An illustrated biography of the dopamine molecule, with each chapter presenting a specific stage in the biochemical pathway for dopamine.
Author: Edythe D. London
Publisher: Routledge
ISBN: 1351439332
Category : Medical
Languages : en
Pages : 444
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Book Description
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Author: Konrad Maurer
Publisher: Springer Science & Business Media
ISBN: 3642770878
Category : Medical
Languages : en
Pages : 491
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Book Description
In the last two decades imaging of the brain, or neuroimaging, has become an integral part of clinical and research psychiatry. This is due to recent advances in computer technology, which has made it relatively easy to generate brain images representing structure and function of the central nervous system. Currently used clinical diagnostic imaging modalities, such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) , provide predominantly anatomic information. CT images reflect X-ray attenuation distribution within the brain, whereas MRI signals depend primarily on proton sensitivity and tissue relaxivity. The chapter "Structural Imaging Methods" reviews CT and MRI studies on schizophrenic and affective disorders and degenera tive central nervous system diseases. The impact of fast three dimensional (3-0) imaging and the automatic transfer from 3-D elements in the brain to artificial diagrams based on this information is considered. Since the original report of the findings of Ingvar and Franzen in 1974 and the introduction of regional cerebral blood flow (rCBF) measurements, single photon emission computed tomography (SPECT) has been gaining acceptance as one of the major imaging techniques, and it is available in most nuclear medicine depart ments. The section "Functional Imaging Methods (Cerebral Blood Flow - CBF, Single Photon Emission Computerized Tomography - SPECT)" describes rCBF studies with the 133Xe inhalation method utilizing a 254 detector system and rCBF images measured by SPECT using the tracer 99mTc-HMPAO.
