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Author: Aurélie Aupoix
Publisher:
ISBN:
Category :
Languages : fr
Pages : 222
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Book Description
Depuis plusieurs années, le développement des anticancéreux sous formes orales a progressé à grand pas. Alors qu’auparavant l’administration se faisait à l’hôpital entourée de professionnels de santé, la prise se fait dorénavant au domicile du patient. De nombreux avantages se présentent alors à lui (meilleure qualité de vie, gain de temps, moins de complications infectieuses), cependant le fait que le patient soit autonome pose également un certain nombre de problèmes : notamment des problèmes d’observance, en effet un faible taux d’observance est constaté mettant ainsi en jeu la réussite du traitement. Une autre préoccupation importante est abordée dans cette thèse : le risque d’interactions médicamenteuses. Un travail a été réalisé avec les inhibiteurs de tyrosine kinases, afin de répertorier l’ensemble des interactions pouvant survenir. Une analyse des interactions a été ensuite réalisée à partir d’une cohorte de patients fournie par l’assurance maladie.
Author: Aurélie Aupoix
Publisher:
ISBN:
Category :
Languages : fr
Pages : 222
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Book Description
Depuis plusieurs années, le développement des anticancéreux sous formes orales a progressé à grand pas. Alors qu’auparavant l’administration se faisait à l’hôpital entourée de professionnels de santé, la prise se fait dorénavant au domicile du patient. De nombreux avantages se présentent alors à lui (meilleure qualité de vie, gain de temps, moins de complications infectieuses), cependant le fait que le patient soit autonome pose également un certain nombre de problèmes : notamment des problèmes d’observance, en effet un faible taux d’observance est constaté mettant ainsi en jeu la réussite du traitement. Une autre préoccupation importante est abordée dans cette thèse : le risque d’interactions médicamenteuses. Un travail a été réalisé avec les inhibiteurs de tyrosine kinases, afin de répertorier l’ensemble des interactions pouvant survenir. Une analyse des interactions a été ensuite réalisée à partir d’une cohorte de patients fournie par l’assurance maladie.
Author: W. Queisser
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 320
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Book Description
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
ISBN:
Category : Health & Fitness
Languages : en
Pages : 536
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Book Description
Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241547006
Category : Health & Fitness
Languages : en
Pages : 284
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Book Description
Most women who die from cervical cancer, particularly in developing countries, are in the prime of their life. They may be raising children, caring for their family, and contributing to the social and economic life of their town or village. Their death is both a personal tragedy, and a sad and unnecessary loss to their family and their community. Unnecessary, because there is compelling evidence, as this Guide makes clear, that cervical cancer is one of the most preventable and treatable forms of cancer, as long as it is detected early and managed effectively. Unfortunately, the majority of women in developing countries still do not have access to cervical cancer prevention programmes. The consequence is that, often, cervical cancer is not detected until it is too late to be cured. An urgent effort is required if this situation is to be corrected. This Guide is intended to help those responsible for providing services aimed at reducing the burden posed by cervical cancer for women, communities and health systems. It focuses on the knowledge and skills needed by health care providers, at different levels of care.
Author: Alan D. Lopez
Publisher: World Bank Publications
ISBN: 0821362631
Category : Medical
Languages : en
Pages : 511
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Book Description
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Author: Carsten Bokemeyer
Publisher: Elsevier Science Health Science Division
ISBN: 9780080445755
Category : Medical
Languages : en
Pages : 304
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Book Description
Author: Steven Foster
Publisher: Psychology Press
ISBN: 0789007053
Category : Family & Relationships
Languages : en
Pages : 474
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Book Description
"Researchers, get busy!" and "caveat emptor" are the messages of this iteration (last, 1993; first, 1982) by herbalists Tyler (pharmacognosy, Purdue U.) and Foster, as they cull herbs' healing virtues from the hype. Alphabetical entries from alfalfa to yucca provide: a brief description, proper nomenclature, plant from which derived, comments on usage, accessible discussion of the chemistry/pharmacology of its active components, evaluation of probable utility, and references. A 16-page summary chart may alone be worth the price. No illustrations, though. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Se-Kwon Kim
Publisher: John Wiley & Sons
ISBN: 1119977657
Category : Science
Languages : en
Pages : 871
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Book Description
The Handbook of Macroalgae: Biotechnology and Applied Phycology describes the biological, biotechnological and the industrial applications of seaweeds. Vast research into the cultivation of seaweeds is currently being undertaken but there is a lack of methodological strategies in place to develop novel drugs from these sources. This book aims to rectify this situation, providing an important review of recent advances and potential new applications for macroalgae. Focusing on the chemical and structural nature of seaweeds the book brings the potentially valuable bioactive nature to the fore. Novel compounds isolated from seaweeds are reviewed to provide an invaluable reference for anyone working in the field.
Author: Hugh D.C. Smyth
Publisher: Springer Science & Business Media
ISBN: 1441997458
Category : Medical
Languages : en
Pages : 560
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Book Description
The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.
Author: Ian Renwick McWhinney
Publisher:
ISBN: 9781927352106
Category : Family medicine
Languages : en
Pages :
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Book Description
