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Author: Jerome Morchain
Publisher: Elsevier
ISBN: 0081011660
Category : Technology & Engineering
Languages : en
Pages : 220
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Book Description
Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. - Presents a multiphase description of bioreactor modeling - Includes a combination of concepts issued from different scientific fields to address a practical issue - Provides a detailed description of the population balance concept as applied to biological systems - Covers a set of illustrative examples of the interaction between hydrodynamics and biological response
Author: Jerome Morchain
Publisher: Elsevier
ISBN: 0081011660
Category : Technology & Engineering
Languages : en
Pages : 220
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Book Description
Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. - Presents a multiphase description of bioreactor modeling - Includes a combination of concepts issued from different scientific fields to address a practical issue - Provides a detailed description of the population balance concept as applied to biological systems - Covers a set of illustrative examples of the interaction between hydrodynamics and biological response
Author: K. Schügerl
Publisher: Springer Science & Business Media
ISBN: 3642597351
Category : Science
Languages : en
Pages : 639
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Book Description
Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.
Author: Christoph Wittmann
Publisher: John Wiley & Sons
ISBN: 3527341811
Category : Science
Languages : en
Pages : 642
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Book Description
The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.
Author: Juan A. Asenjo
Publisher: CRC Press
ISBN: 1482277476
Category : Science
Languages : en
Pages : 641
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Book Description
Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such
Author: Lakhveer Singh
Publisher: Elsevier
ISBN: 0128212640
Category : Science
Languages : en
Pages : 336
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Book Description
Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.
Author: Rosane F. Schwan
Publisher: CRC Press
ISBN: 0429754396
Category : Technology & Engineering
Languages : en
Pages : 649
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Book Description
Bioreactor Technology in Food Processing brings peculiarities, specificities, and updates on bioreactors and bioprocesses related to food and beverage production. The 26 chapters of this book are the result of the participation of more than 70 professionals, including professors, researchers, and experts from the industrial sector from different countries around the world. The chapters cover such topics as history, classification, scale-up, analytical tools, and mathematical and kinetic models for the operation of bioreactors in the food industry. In addition, chapters detail the characteristics of bioreactors for the production of food (bread, cheese, and coffee fermentation) and fermented beverages (beer, wine), distilled beverages, and organic compounds such as enzymes, acids, aromas, and pigments (biocolorants), among others. Key Features: Describes the basic and applied aspects of bioreactor in food processing Gathers information on bioreactors that is scattered in different journals and monographs as reviews and research articles Covers various types of bioreactors including stirred tank, airlift, photo-bioreactor, and disposable bioreactors Gives a broad overview of what exactly is involved in designing a bioreactor and optimizing its performance and finally their applications in the food processing industry The broad interdisciplinary approach of this book will certainly make your reading very interesting, and we hope that it can contribute to knowledge and instigate creative thinking to overcome the challenges that food bioprocessing brings us.
Author: Cornelia Kasper
Publisher: Springer Science & Business Media
ISBN: 3540693564
Category : Science
Languages : en
Pages : 274
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Book Description
The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.
Author: Sushovan Sarkar
Publisher: Springer Nature
ISBN: 9813345462
Category : Science
Languages : en
Pages : 130
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Book Description
This book describes a simplified approach to the modelling and process design of a fixed bed hybrid bioreactor for wastewater treatment. In this work a simplified model for hybrid bioreactor is developed to determine output parameters like exiting substrate concentration in bulk liquid, average substrate flux in the biofilm, effective and total biofilm thickness. The model is based on mass balance of both carbonaceous substrate and biomass under suspended and attached growth simultaneously along with substrate mass transport into the biofilm. The proposed model has also been validated with the results obtained from experimental study with municipal wastewater considering as a low strength wastewater with no inhibition. There is a flexibility of the proposed model making it a versatile one to find out the exiting substrate concentration both in hybrid bioreactor as well as in a completely mixed biofilm reactor (CMBR). The book caters to academics and practitioners working in the field of advanced wastewater treatment.
Author: Enes Kadic
Publisher: John Wiley & Sons
ISBN: 1118869834
Category : Science
Languages : en
Pages : 330
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Book Description
Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current process needs Reviews the problems of bioreactor selection globally while considering all bioreactor options rather than concentrating on one specific bioreactor type
Author: Ashok Pandey
Publisher: Elsevier
ISBN: 0323984835
Category : Technology & Engineering
Languages : en
Pages : 523
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Book Description
Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future. - Covers state-of-the-art, technological advancements in the field of bioprocessing - Includes design and scale-up of bioreactors, monitoring and control systems, advances in upstream and downstream processing - Includes design and development of fermentation processes such as the suitability of experimental design, full factorial, central composite design, Box-Behnken, Plackett-Burman, and more
