Bioorganic Chemistry of Biological Signal Transduction PDF Download
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Author: Herbert Waldmann
Publisher: Springer
ISBN: 3540450351
Category : Science
Languages : en
Pages : 235
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Book Description
The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced, belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate, for instance, the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology, medical research and chemistry working in academic research institutions or in industry.
Author: Herbert Waldmann
Publisher: Springer
ISBN: 3540450351
Category : Science
Languages : en
Pages : 235
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Book Description
The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced, belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate, for instance, the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology, medical research and chemistry working in academic research institutions or in industry.
Author: Herbert Waldmann
Publisher: Springer
ISBN: 9783540450351
Category : Science
Languages : en
Pages : 230
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Book Description
Author: David Van Vranken
Publisher: Garland Science
ISBN: 1135054827
Category : Medical
Languages : en
Pages : 571
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Book Description
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science. Please note that Garland Science flashcards are no longer available for this text. However, the solutions can be obtained through our Support Material Hub link below, but should only be requested by instructors who have adopted the book on their course.
Author: Robert Allen Meyers
Publisher: John Wiley & Sons
ISBN: 9780471186342
Category : Medical
Languages : en
Pages : 1090
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Book Description
This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.
Author: Werner Krause
Publisher: Springer
ISBN: 354045733X
Category : Science
Languages : en
Pages : 251
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Book Description
Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].
Author: Yuichi Kobayashi
Publisher: Springer
ISBN: 9811362440
Category : Science
Languages : en
Pages : 371
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Book Description
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.
Author: Nouri Neamati
Publisher: John Wiley & Sons
ISBN: 1118015363
Category : Science
Languages : en
Pages : 710
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Book Description
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Author: Fritz Vögtle
Publisher: John Wiley & Sons
ISBN: 9783527299782
Category : Science
Languages : en
Pages : 426
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Book Description
Fresh ideas have always been a necessary ingredient for progress in chemistry. Without a continuous supply of stimulating ideas from creative researchers, there would be no new insights into the subject. But what are some of the ideas that pervade modern chemistry? The answer to this question is to be found in "Stimulating Concepts in Chemistry". In a collection of 24 essays, a group of leading researchers provides an overview of the most recent developments in their fields. Readers can find out about modern concepts in chemistry such as self-assembly, nanochemistry, and molecular machines. Moreover, many spectacular advances have been achieved from the fusion of chemistry with life and materials science - a development which is illustrated by contributions on enzyme mimics, molecular wires, and chemical sensors. Further, the essayists write about new nanomaterials, efficient methods in synthesis, and big biomolecules - indeed, many of the topics that have dominated some of the recent discussions in chemistry. This outstanding text makes use of a special layout to reflect the editors' aim of presenting concepts in the form of essays. Thus, the book is not merely another source of knowledge but is intended to stimulate readers to develop their own ideas and concepts. This format should help to make the book interesting to a wide range of scientists. Students of chemistry will benefit from the different style of presentation of their subject, while researchers in industry and academia will welcome the exciting way in which some of the most challenging concepts in modern chemistry are presented.
Author: American Chemical Society
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 1096
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Book Description
Author: Carsten Schmuck
Publisher: John Wiley & Sons
ISBN: 3527604081
Category : Science
Languages : en
Pages : 600
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Book Description
This is a fascinating introduction to the topic. Spanning the spectrum of nucleic acid chemistry, carbohydrates, peptides, molecular recognition, biosynthesis and natural biosynthesis, right up to medical and biophysical chemistry, the book provides advanced students and those already working in the field with a balanced overview. In more than 30 contributions, a new generation of recognized scientists gives an account of the latest research in such areas as * Artificial receptors for the stabilization of ß-sheet structures * Carbohydrate recognition by artificial receptors * Combinatorial chemistry as a tool for the discovery of catalysts * The interaction of NO and peroxynitrite with hemoglobin and myoglobin * Inhibitors against human mast-cell-tryptase as a potential approach to conquering asthma * The selectivity of DNA replication. A readily accessible survey for everyone wishing to stay abreast of developments. With a Foreword by Ronald Breslow.
