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Author: Gerhard A. Holzapfel
Publisher: Springer
ISBN: 3319414755
Category : Technology & Engineering
Languages : en
Pages : 319
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Book Description
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Author: Gerhard A. Holzapfel
Publisher: Springer
ISBN: 3319414755
Category : Technology & Engineering
Languages : en
Pages : 319
Get Book Here
Book Description
The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Author: Dongwoon Lee
Publisher: Foundations and Trends(r) in C
ISBN: 9781601985521
Category : Computers
Languages : en
Pages : 62
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Book Description
Surveys various approaches to model and simulate muscles both morphologically and functionally.
Author: Ugo Andreaus
Publisher: Springer Science & Business Media
ISBN: 940074269X
Category : Technology & Engineering
Languages : en
Pages : 208
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Book Description
This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease. The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis
Author: Enrico Dall’Ara
Publisher: Frontiers Media SA
ISBN: 2832500382
Category : Science
Languages : en
Pages : 271
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Book Description
Author: Christian Brosseau
Publisher: Springer Nature
ISBN: 3031379810
Category : Science
Languages : en
Pages : 304
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Book Description
This book covers the recently developed understanding of Electro-Mechano-Biology (EMB) in which the focus is primarily on the couplings between the electric and mechanical fields. The emphasis lies on the analytical and computational aspects of EMB at the cellular level. The book is divided into two parts. In the first part, the author starts by defining and discussing the relevant basic aspects of the electrical and mechanical properties of cell membranes. He provides an overview of some of the ways analytical modelling of cell membrane electrodeformation (ED) and electroporation (EP) appears in a variety of contexts as well as a contemporary account of recent developments in computational approaches that can feature in the theory initiative, particularly in its attempt to describe the cohort of activities currently underway. Intended to serve as an introductory text and aiming to facilitate the understanding of the field to non-experts, this part does not dwell on the set of topics, such as cellular mechanosensing and mechanotransduction, irreversible EP, and atomistic molecular dynamics modelling of membrane EP. The second (and larger) part of the book is devoted to a presentation of the necessary analytical and computational tools to illustrate the ideas behind EMB and illuminate physical insights. Brief notes on the history of EMB and its many applications describing the variety of ideas and approaches are also included. In this part, the background of the first principles and practical calculation methods are discussed to highlight aspects that cannot be found in a single volume.
Author: Merab Svanadze
Publisher: Springer Nature
ISBN: 3030280225
Category : Mathematics
Languages : en
Pages : 313
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Book Description
This monograph explores the application of the potential method to three-dimensional problems of the mathematical theories of elasticity and thermoelasticity for multi-porosity materials. These models offer several new possibilities for the study of important problems in engineering and mechanics involving multi-porosity materials, including geological materials (e.g., oil, gas, and geothermal reservoirs); manufactured porous materials (e.g., ceramics and pressed powders); and biomaterials (e.g., bone and the human brain). Proceeding from basic to more advanced material, the first part of the book begins with fundamental solutions in elasticity, followed by Galerkin-type solutions and Green’s formulae in elasticity and problems of steady vibrations, quasi-static, and pseudo-oscillations for multi-porosity materials. The next part follows a similar format for thermoelasticity, concluding with a chapter on problems of heat conduction for rigid bodies. The final chapter then presents a number of open research problems to which the results presented here can be applied. All results discussed by the author have not been published previously and offer new insights into these models. Potential Method in Mathematical Theories of Multi-Porosity Media will be a valuable resource for applied mathematicians, mechanical, civil, and aerospace engineers, and researchers studying continuum mechanics. Readers should be knowledgeable in classical theories of elasticity and thermoelasticity.
Author: Bela Suki
Publisher: Academic Press
ISBN: 0128226056
Category : Technology & Engineering
Languages : en
Pages : 284
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Book Description
Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. - Examines the evolutionary origins and consequences of the extracellular matrix - Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system - Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning - Provides an introduction to the properties and organization of the extracellular matrix components
Author: Georges Limbert
Publisher: Springer
ISBN: 303013279X
Category : Technology & Engineering
Languages : en
Pages : 303
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Book Description
This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.
Author: Yanhang Zhang
Publisher: Springer
ISBN: 3030201821
Category : Technology & Engineering
Languages : en
Pages : 401
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Book Description
This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Author: Vaclav Klika
Publisher: BoD – Books on Demand
ISBN: 9533078510
Category : Medical
Languages : en
Pages : 418
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Book Description
During last couple of years there has been an increasing recognition that problems arising in biology or related to medicine really need a multidisciplinary approach. For this reason some special branches of both applied theoretical physics and mathematics have recently emerged such as biomechanics, mechanobiology, mathematical biology, biothermodynamics. This first section of the book, General notes on biomechanics and mechanobiology, comprises from theoretical contributions to Biomechanics often providing hypothesis or rationale for a given phenomenon that experiment or clinical study cannot provide. It deals with mechanical properties of living cells and tissues, mechanobiology of fracture healing or evolution of locomotor trends in extinct terrestrial giants. The second section, Biomechanical modelling, is devoted to the rapidly growing field of biomechanical models and modelling approaches to improve our understanding about processes in human body. The last section called Locomotion and joint biomechanics is a collection of works on description and analysis of human locomotion, joint stability and acting forces.
