Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease PDF Download
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Author: Pingyi Xu
Publisher: Frontiers Media SA
ISBN: 2889741435
Category : Science
Languages : en
Pages : 367
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Book Description
Author: Pingyi Xu
Publisher: Frontiers Media SA
ISBN: 2889741435
Category : Science
Languages : en
Pages : 367
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Book Description
Author: Susan Costantini Alfredo Budillon
Publisher: MDPI
ISBN: 3039439774
Category : Medical
Languages : en
Pages : 294
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Book Description
Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Davide Martino
Publisher: Springer
ISBN: 3662484684
Category : Medical
Languages : en
Pages : 458
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Book Description
This concise but comprehensive book will help interested readers in the health care professions to navigate their way through the jungle of movement disorders, including the potentially complex differential diagnosis and management. The different disorders are discussed in individual sections that explain how to examine the patient and recognize the disorder from its basic phenomenology, how to confirm a diagnosis, how to distinguish a particular disorder from related conditions, and how to treat each disorder effectively. The book makes liberal use of diagrams, algorithms, tables, summary boxes, and illustrations to facilitate solution of clinical problems at the bedside and to solidify previously learned clinical and therapeutic concepts. It will be of interest to a broad audience of health professionals, scientists, and medical students.
Author: Margaret M. Esiri
Publisher: Cambridge University Press
ISBN: 9780521819152
Category : Medical
Languages : en
Pages : 600
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Book Description
Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.
Author: Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
Publisher: BoD – Books on Demand
ISBN: 9533074620
Category : Medical
Languages : en
Pages : 556
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Book Description
This book about Parkinson's disease provides a detailed account of etiology and pathophysiology of Parkinson's disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson's disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson's disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson's disease.
Author: Rodrigo Franco
Publisher: Royal Society of Chemistry
ISBN: 1782621881
Category : Medical
Languages : en
Pages : 537
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Book Description
Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.
Author: Stewart A. Factor, DO
Publisher: Demos Medical Publishing
ISBN: 1934559873
Category : Medical
Languages : en
Pages : 858
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Book Description
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.
Author: Anthony Schapira
Publisher: John Wiley & Sons
ISBN: 1118661915
Category : Medical
Languages : en
Pages : 1078
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Book Description
This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors
Author: Hash Brown Taha
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Synucleinopathies are a group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of [alpha]-synuclein ([alpha]-syn) in Lewy bodies (LBs) in PD and DLB or as glial cytoplasmic inclusions in MSA. Current antemortem differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) is challenging due to the overlap of Parkinsonian symptoms, especially in the early stages. Analysis of biomarkers in CNS-originating extracellular vesicles (EVs) isolated from blood is a promising strategy for these diseases. EVs are released by all cell types and pass through the blood-brain barrier, providing a proxy of the brain's biochemistry. We have shown previously that [alpha]-synuclein ([alpha]-syn) concentration in neuronal- and oligodendroglial-EVs (nEVs and oEVs, respectively) isolated from the serum or plasma of healthy controls (HC), and patients with PD or MSA allowed separating MSA from both HC and PD with high sensitivity and specificity. In healthy brains, only ∼4% of [alpha]-syn is phosphorylated at Ser129 (pS129-[alpha]-syn), whereas >90% pS129-[alpha]-syn may be found in LBs, suggesting that pS129-[alpha]-syn could be a helpful biomarker for synucleinopathies. Further, tau is implicated in patients with PD but not MSA. Here, I describe the development of a novel electrochemiluminescence ELISA for the measurement of pS129-[alpha]-syn in nEVs and oEVs based on the Meso Scale Discovery platform. Using this in-house assay and other commercial assays, we measured [alpha]-syn phosphorylated at Ser 129 (pS129-[alpha]-syn), total tau, and neurofilament light chain (NfL) in subsets of patients with PD, MSA or HCs to test if they improved the diagnostic power.The findings may suggest that a biomarker panel compromising nEVs [alpha]-syn, oEVs:nEVs [alpha]-syn, oEVs pS129-[alpha]-syn and exosome concentration may help distinguish patients with PD from MSA. However, many limitations currently exist with issues related to preanalytical variables, the need for independent validation and replication, differing postmortem diagnosis from the antemortem diagnosis, assay matrix effects, and issues with the L1CAM antibody, among others. Several notable limitations are associated with the current state of research in this area. These limitations encompass various factors such as preanalytical variables, the necessity for independent validation and replication, discrepancies between postmortem and antemortem diagnoses, assay matrix effects, challenges related to the L1CAM antibody, and other related issues.
