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Author: Rene Thomas
Publisher: CRC Press
ISBN: 9780849367663
Category : Science
Languages : en
Pages : 328
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Book Description
Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.
Author: Rene Thomas
Publisher: CRC Press
ISBN: 9780849367663
Category : Science
Languages : en
Pages : 328
Get Book
Book Description
Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.
Author: Richard Jones
Publisher: Elsevier
ISBN: 0323153534
Category : Science
Languages : en
Pages : 375
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Book Description
Principles of Biological Regulation: An Introduction to Feedback Systems presents some understanding of control, regulatory, and feedback mechanisms in biological systems. This book discusses concepts related to the dynamic behavior of both individual biological processes and systems of processes that make up an organism. Comprised of 10 chapters, the book also describes the characteristics of biological feedback systems, focusing on the physical concepts. After briefly dealing with involved regulatory processes in biological systems, the book goes on discussing the flow or transport of material through a series of processes in the steady-state. Next chapter uses superposition principle to explain the changes that biological systems undergo following a disturbance or under dynamic behavior. The subsequent chapters cover the fundamental principles of negative biological feedback and to the effects it produces both under steady-state and dynamic behavior. Other chapters describe the effect of sinusoid signals on biological processes and present some stability criteria applied to technological systems and also their value in the study of homeostatic processes. The book also discusses some aspects of homeostats that seem to distinguish them from technological feedback systems. These features include not only the components themselves and their organization, but also the experimental problems involved in their study. The concluding chapters describe nonlinear behavior with great relevance to homeostatic systems and rate processes (production or destruction) for which the roles of stimulus and initial conditions are different. Mathematical relations developed from the conservation of mass and the mass action for chemical reactions are also presented. The book is an invaluable resource for life scientists and researchers.
Author: Daniel B. Forger
Publisher: MIT Press
ISBN: 0262036770
Category : Science
Languages : en
Pages : 369
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Book Description
An introduction to the mathematical, computational, and analytical techniques used for modeling biological rhythms, presenting tools from many disciplines and example applications. All areas of biology and medicine contain rhythms, and these behaviors are best understood through mathematical tools and techniques. This book offers a survey of mathematical, computational, and analytical techniques used for modeling biological rhythms, gathering these methods for the first time in one volume. Drawing on material from such disciplines as mathematical biology, nonlinear dynamics, physics, statistics, and engineering, it presents practical advice and techniques for studying biological rhythms, with a common language. The chapters proceed with increasing mathematical abstraction. Part I, on models, highlights the implicit assumptions and common pitfalls of modeling, and is accessible to readers with basic knowledge of differential equations and linear algebra. Part II, on behaviors, focuses on simpler models, describing common properties of biological rhythms that range from the firing properties of squid giant axon to human circadian rhythms. Part III, on mathematical techniques, guides readers who have specific models or goals in mind. Sections on “frontiers” present the latest research; “theory” sections present interesting mathematical results using more accessible approaches than can be found elsewhere. Each chapter offers exercises. Commented MATLAB code is provided to help readers get practical experience. The book, by an expert in the field, can be used as a textbook for undergraduate courses in mathematical biology or graduate courses in modeling biological rhythms and as a reference for researchers.
Author: Donald L. DeAngelis
Publisher: Springer Science & Business Media
ISBN: 3642826253
Category : Mathematics
Languages : en
Pages : 292
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Book Description
Cybernetics, a science concerned with understanding how systems are regulated, has reflected the preoccupations of the century in which it was born. Regulation is important in twentieth century society, where both machines and social organizations are complex. Cybernetics focused on and became primarily associated with the homeostasis or stability of system behavior and with the negative feedbacks that stabilize systems. It paid less attention to the processes opposite to negative feedback, the positive feedback processes that act to change systems. We attempt to redress the balance here by illustrating the enormous importance of positive feedbacks in natural systems. In an article in the American Scientist in 1963, Maruyama called for increased attention to this topic, noting that processes of change could occur when a "deviation in anyone component of the system caused deviations in other components that acted back on the first component to reinforce of amplify the initial deviation." The deviation amplification is the result of positive feedback among system components. Maruyama demonstrated by numerous examples that the neglect of such processes was unjustified and suggested that a new branch of cybernetics, "the second cybernetics," be devoted to their study.
Author: Donald Lee DeAngelis
Publisher: Springer Verlag
ISBN: 9780387159423
Category : Science
Languages : en
Pages : 0
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Book Description
Author: Domitilla Del Vecchio
Publisher: Princeton University Press
ISBN: 1400850509
Category : Science
Languages : en
Pages : 287
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Book Description
This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applications Covers the most commonly used modeling methods Addresses the modular design problem for biomolecular systems Uses design examples from both natural systems and synthetic circuits Solutions manual (available only to professors at press.princeton.edu) An online illustration package is available to professors at press.princeton.edu
Author: Ron Milo
Publisher: Garland Science
ISBN: 1317230698
Category : Science
Languages : en
Pages : 400
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Book Description
A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309120926
Category : Science
Languages : en
Pages : 90
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Book Description
Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?
Author: Barney K. Huang
Publisher: CRC Press
ISBN: 9780849348693
Category : Technology & Engineering
Languages : en
Pages : 892
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Book Description
Computer Simulation Analysis of Biological and Agricultural Systems focuses on the integration of mathematical models and the dynamic simulation essential to system analysis, design, and synthesis. The book emphasizes the quantitative dynamic relationships between elements and system responses. Problems of various degrees of difficulty and complexity are discussed to illustrate methods of computer-aided design and analysis that can bridge the gap between theories and applications. These problems cover a wide variety of subjects in the biological and agricultural fields. Specific guidelines and practical methods for defining requirements, developing specifications, and integrating system modeling early in simulation development are included as well. Computer Simulation Analysis of Biological and Agricultural Systems is an excellent text and self-guide for agricultural engineers, agronomists, foresters, horticulturists, soil scientists, mechanical engineers, and computer simulators.
Author: Douglas Stone
Publisher: Penguin
ISBN: 0143127136
Category : Business & Economics
Languages : en
Pages : 370
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Book Description
The coauthors of the New York Times–bestselling Difficult Conversations take on the toughest topic of all: how we see ourselves Douglas Stone and Sheila Heen have spent the past fifteen years working with corporations, nonprofits, governments, and families to determine what helps us learn and what gets in our way. In Thanks for the Feedback, they explain why receiving feedback is so crucial yet so challenging, offering a simple framework and powerful tools to help us take on life’s blizzard of offhand comments, annual evaluations, and unsolicited input with curiosity and grace. They blend the latest insights from neuroscience and psychology with practical, hard-headed advice. Thanks for the Feedback is destined to become a classic in the fields of leadership, organizational behavior, and education.
