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Author: Christopher H. Evans
Publisher: Springer Science & Business Media
ISBN: 1468487485
Category : Science
Languages : en
Pages : 453
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Book Description
By a happy coincidence, the completion of this text coincided with the 200th anniversary of the discovery of gadolinite, the mineral with which the lanthanide story begins. For a group of elements which occur in only trace amounts biologically, and which have no known metabolic role, the lanthanides have spawned a surprisingly large biochemicalliterature. Se rious interest in the biochemical properties ofthese elements can be traced to concerns about the safety of radioactive lanthanides toward the end of World War 11. As recent events at Chernobyl indicate, this concern re mains topical. However, the literature on lanthanide biochemistry pre dates the atomic era, beginning with sporadic, medically motivated studies in the latter part of the 19th century. Much of the present biochemical activity involving the lanthanides centers around their ability to provide 2 important information on the interactions of Ca + with macromolecules and with eukafyotic cells. With the increasing industrial use of the lan thanides, their toxicological properties will need to be examined more closely. Rare earth pneumonoconiosis has already been identified as a disease produced by industrial exposure to lanthanides. Several of the biochemical properties of the lanthanides are of relevance to modern medicine. Already cerium-based ointments are used to treat burn wounds, while paramagnetic lanthanides find application in nuclear magnetic res onance imaging. This book is an attempt to collate and to present in reasonable detail existing knowledge of lanthanide biochemistry before the literature be comes unmanageable.
Author: Christopher H. Evans
Publisher: Springer Science & Business Media
ISBN: 1468487485
Category : Science
Languages : en
Pages : 453
Get Book Here
Book Description
By a happy coincidence, the completion of this text coincided with the 200th anniversary of the discovery of gadolinite, the mineral with which the lanthanide story begins. For a group of elements which occur in only trace amounts biologically, and which have no known metabolic role, the lanthanides have spawned a surprisingly large biochemicalliterature. Se rious interest in the biochemical properties ofthese elements can be traced to concerns about the safety of radioactive lanthanides toward the end of World War 11. As recent events at Chernobyl indicate, this concern re mains topical. However, the literature on lanthanide biochemistry pre dates the atomic era, beginning with sporadic, medically motivated studies in the latter part of the 19th century. Much of the present biochemical activity involving the lanthanides centers around their ability to provide 2 important information on the interactions of Ca + with macromolecules and with eukafyotic cells. With the increasing industrial use of the lan thanides, their toxicological properties will need to be examined more closely. Rare earth pneumonoconiosis has already been identified as a disease produced by industrial exposure to lanthanides. Several of the biochemical properties of the lanthanides are of relevance to modern medicine. Already cerium-based ointments are used to treat burn wounds, while paramagnetic lanthanides find application in nuclear magnetic res onance imaging. This book is an attempt to collate and to present in reasonable detail existing knowledge of lanthanide biochemistry before the literature be comes unmanageable.
Author: Pekka Hänninen
Publisher: Springer Science & Business Media
ISBN: 3642210236
Category : Science
Languages : en
Pages : 392
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Book Description
Lanthanides have fascinated scientists for more than two centuries now, and since efficient separation techniques were established roughly 50 years ago, they have increasingly found their way into industrial exploitation and our everyday lives. Numerous applications are based on their unique luminescent properties, which are highlighted in this volume. It presents established knowledge about the photophysical basics, relevant lanthanide probes or materials, and describes instrumentation-related aspects including chemical and physical sensors. The uses of lanthanides in bioanalysis and medicine are outlined, such as assays for in vitro diagnostics and research. All chapters were compiled by renowned scientists with a broad audience in mind, providing both beginners in the field and advanced researchers with comprehensive information on on the given subject.
Author: Pabitra Krishna Bhattacharya
Publisher: CRC Press
ISBN: 1000292665
Category : Science
Languages : en
Pages : 428
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Book Description
The second edition of Metal Ions in Biochemistry deals with the multidisciplinary subject of bio-inorganic chemistry, encompassing the disciplines of inorganic chemistry, biochemistry and medicine. The book deals with the role of metal ions in biochemistry, emphasising that biochemistry is mainly the chemistry of metal-biochemical complexes. Hence, the book starts with the structures of biochemicals and the identification of their metal binding sites. Thermodynamic and kinetic properties of the complexes are explained from the point of view of the nature of metal-ligand bonds. Various catalytic and structural roles of metal ions in biochemicals are discussed in detail. Features The role of Na+ and K+ in brain chemistry. The role of zinc insulin in glucose metabolism and its enhancement by vanadium and chromium compounds. Discussion of the role of zinc signals, zinc fingers and cascade effect in biochemistry. Haemoglobin synthesis and the role of vitamin B12 in it. The role of lanthanides in biochemical systems. A detailed discussion of the role of non-metals in biochemistry, a topic missing in most of the books on bio-inorganic chemistry. The study of bio-inorganic chemistry makes biochemists rethink the mechanistic pathways of biochemical reactions mediated by metal ions. There is a realisation of the role of metal complexes and inorganic ions as therapeutics such as iron in leukaemia, thalassemia and sickle cell anaemia, iodine in hypothyroidism and zinc, vanadium and chromium in glucose metabolism. The most recent realisation is of the use of zinc in the prevention and treatment of COVID-19.
Author: C. Anthony
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 458
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Book Description
Author:
Publisher: Academic Press
ISBN: 0323910866
Category : Science
Languages : en
Pages : 414
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Book Description
Rare-Earth Element Biochemistry: Characterization and Applications of Lanthanide-Binding Biomolecules, Volume 651 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Spectrophotometric methods to probe the solution chemistry of lanthanide complexes with macromolecules, Determination of affinities of lanthanide-binding proteins using chelator-buffered titrations, Electron Paramagnetic Resonance of Lanthanides, Characterization of lanthanoid binding proteins using NMR spectroscopy, Macromolecular crystallography for f-element complex characterization, Infrared spectroscopy probes ion binding geometries, Predicting lanthanide coordination structures in solution with molecular simulation, and much more. Additional sections cover the Characteristics of Gd(III) spin labels for the study of protein conformations, Lanthanide-based resonance energy transfer biosensors for live-cell applications, Yttrium-86 PET imaging, Aqueous Chemistry of the Smallest Rare Earth: Comprehensive Characterization of Radioactive and Non-radioactive Scandium Complexes for Biological Applications, and In vitro selection and application of lanthanide-dependent DNAzymes. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series
Author:
Publisher: Academic Press
ISBN: 0128238577
Category : Science
Languages : en
Pages : 278
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Book Description
Methods in Enzymology, Volume 650 continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Biophysical methods to study lanthanide-protein interactions, Genetically encoded sensors to study lanthanide biology, Spectrophotometric methods to determine the stability constants of lanthanide-macromolecule complexes, Lanthanide-based probes for amino acid modifications, In vitro selection and application of lanthanide-dependent DNAzymes, LRET biosensors for imaging protein interactions in living cells, Synthetic Modeling of the Structure and Function of the Lanthanide-Dependent, MDH Cofactor, EPR spectroscopy of lanthanides, Macromolecular crystallography for f-element complex characterization, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series
Author: Shintaro T. Suzuki
Publisher: Springer
ISBN: 4431560335
Category : Science
Languages : en
Pages : 425
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Book Description
This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.
Author: Joseph A. Cotruvo
Publisher: Elsevier
ISBN: 0323910858
Category : Science
Languages : en
Pages : 412
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Book Description
Spectrophotometric methods to probe the solution chemistry of lanthanide complexes with macromolecules / Gauthier J.-P. Deblonde -- Determination of affinities of lanthanide-binding proteins using chelator-buffered titrations / Joseph A. Mattocks, Jonathan L. Tirsch, and Joseph A. Cotruvo, Jr. -- Electron paramagnetic resonance of lanthanides / Joseph E. McPeak, Sandra S. Eaton, and Gareth R. Eaton -- Characterization of lanthanoid-binding proteins using NMR spectroscopy / Enrico Ravera, Linda Cerofolini, Marco Fragai, Giacomo Parigi, and Claudio Luchinat -- Macromolecular crystallography for f-element complex characterization / Roger M. Pallares, Korey P. Carter, David Faulkner, and Rebecca J. Abergel -- Infrared spectroscopy probes ion binding geometries / Sean C. Edington, Stephanie Liu, and Carlos R. Baiz -- Predicting lanthanide coordination structures in solution with molecular simulation / David C. Cantu -- Characteristics of Gd(III) spin labels for the study of protein conformations / Angeliki Giannoulis, Yasmin Ben-Ishay, and Daniella Goldfarb - Lanthanide-based resonance energy transfer biosensors for live-cell applications / Ha Pham and Lawrence W. Miller -- 86Y PET imaging / Mariane Le Fur and Peter Caravan -- Aqueous chemistry of the smallest rare earth : Comprehensive characterization of radioactive and non-radioactive scandium complexes for biological applications / Brett A. Vaughn, Angus J. Koller, and Eszter Boros -- In vitro selection and application of lanthanide-dependent DNAzymes / Po-Jung Jimmy Huang and Juewen Liu.
Author: Chaim T. Horovitz
Publisher: Springer Science & Business Media
ISBN: 1461543134
Category : Science
Languages : en
Pages : 334
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Book Description
Biochemistry of Scandium and Yttrium gathers together existing knowledge about scandium and yttrium from a wide variety of disciplines. Part 1 will present a comparative study of the physical and chemical properties of scandium and yttrium, looking at both their similarities and their differences. (Part 2 will address the biochemical aspects of these two elements, and the various medical and environmental applications.) While these elements are relatively rare in nature, these books will show that they have unusual physical and chemical properties, and a disproportionate number of important applications. Improved analytical techniques have revealed that scandium and yttrium are present throughout living matter, even though only a relatively limited number of species have been analyzed so far. This fact of course has far-ranging implications for biological and environmental concerns. Part 1 also contains a discussion of the interactions of scandium and yttrium with molecules of biological interest, such as organic acids, carbohydrates, proteins, nucleotides, and other biologically active molecules. The major impacts of scandium and yttrium in science, technology, and medicine will be of interest to a wide variety of researchers, including geochemists, inorganic and organic chemists, clinical biochemists, and those specializing in environmental protection. Biochemistry of Scandium and Yttrium, Part 1 and Part 2 will be especially welcome because the last book published on the biochemistry of scandium appeared over 20 years ago, and the only book mentioning the biochemistry of yttrium came out in 1990.
Author: N.D. Chasteen
Publisher: Springer Science & Business Media
ISBN: 9400920237
Category : Science
Languages : en
Pages : 226
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Book Description
Over the past several decades, vanadium has increasingly attracted the interest of biologists and chemists. The discovery by Henze in 1911 that certain marine ascidians accumulate the metal in their blood cells in unusually large quantities has done much to stimulate research on the role of vanadium in biology. In the intervening years, a large number of studies have been carried out to investigate the toxicity of vanadium in higher animals and to determine whether it is an essential trace element. That vanadium is a required element for a few selected organisms is now well established. Whether vanadium is essential for humans remains unclear although evidence increasingly suggests that it probably is. The discovery by Cantley in 1977 that vanadate is a potent inhibitor of ATPases lead to numerous studies of the inhibitory and stimulatory effects of vanadium on phosphate metabolizing enzymes. As a consequence vanadates are now routinely used as probes to investigate the mechanisms of such enzymes. Our understanding of vanadium in these systems has been further enhanced by the work of Tracy and Gresser which has shown striking parallels between the chemistry of vanadates and phosphates and their biological compounds. The observation by Shechter and Karlish, and Dubyak and Kleinzeller in 1980 that vanadate is an insulin mimetic agent has opened a new area of research dealing with the hormonal effects of vanadium. The first vanadium containing enzyme, a bromoperoxidase from the marine alga Ascophyllum nodosum, was isolated in 1984 by Viltner.
